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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 3 | 平行轴齿轮传动系统布局设计的膨胀方法显示文摘布局设计是齿轮传动系统设计中重要的核心问题之一,它的关键在于建立一种有效的问题表 达和求解模型。提出使用膨胀布局方法来解决这一问题。膨胀方法是一种通过构造布局物体 的膨胀和排斥而自适应地求解物体布局位置的计算方法,能够表达齿轮传动的多层结构和复 杂啮合约束,是较好的齿轮传动系统布局求解模型。 | 陆一平 查建中 Tony C Woo | 2001 | 机械工程学报2001，37，12： | 3 |
| 4 | A robust soc-MOF platform exhibiting high gravimetric uptake and volumetric deliverable capacity for on-board methane storage显示文摘Emerging as an outperformed class of metal-organic frameworks(MOFs),square-octahedron(soc)topology MOFs(soc-MOFs)feature superior properties of high porosity,large gas storage capacity,and excellent thermal/chemical stability.We report here an iron based soc-MOF,denoted as Fe-pbpta(H4pbpta=4,4',4'',4'''-(1,4-phenylenbis(pyridine-4,2-6-triyl))-tetrabenzoic acid)possessing a very high Brunauer,Emmett and Teller(BET)surface area of 4,937 m2/g and a large pore volume of 2.15 cm3/g.The MOF demonstrates by far the highest gravimetric uptake of 369 cm3(STP)/g under the DOE operational storage conditions(35 bar and 298 K)and a high volumetric deliverable capacity of 192 cc/cc at 298 K and 65 bar.Furthermore,Fe-pbpta exhibits high thermal and aqueous stability making it a promising candidate for on-board methane storage. | Gaurav Verma Sanjay Kumar Harsh Vardhan Junyu Ren Zheng Niu Tony Pham Lukasz Wojtas Sydney Butikofer Jose C Echeverria Garcia Yu-Sheng Chen Brian Space and Shengqian Ma | 2021 | Nano Research2021，14，2： | 2 |
| 5 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 6 | Blood levels, apoptosis, and homing of the endothelial progenitor ceils after skin burns and eschareetomy 显示文摘 | Foresta C Schipilliti M De Toni L | 2011 | J Trauma2011，70，2： | 1 |
| 7 | Fouling in membrane bioreactors used in wastewater treatment 显示文摘 | PIERRE L C VICKI C TONY A G | 2006 | Journal of Membrane Science2006，284，： | 1 |
| 8 | Reconstruction of functionally normal and malignant human breast tissues in mice显示文摘 | Charlotte K Tony C Min Wu | 2004 | PNAS2004，101，14： | 1 |
| 9 | An efficient approach for locating the critical slip surface in slope stability analyses using a real-coded genetic algorithm显示文摘 | LI Y C CHEN Y M TONY L T | 2010 | Canadian Geotechnical Journal2010，47，7： | 1 |
| 10 | Open-label evaluation of venlafax- ine sustained release in outpatients with generalized anxiety disorder with comorbid major depression or dysthymia: effectiveness, tolera- bility and predictors of response显示文摘 | Perugi G Frare F Toni C | 2002 | Neuropsychobiology2002，46，3： | 1 |
| 11 | Clinical outcomes with Erlo tinib in patients with epidermal growth factor receptor mutation(NEJGSG002) 显示文摘 | Tony SK Manolo D Raffaele C | 2012 | Drugs2012，，72： | 1 |
| 12 | Blood levels, apoptosis, and homing of the endothelial progenitor cells after skin burns and escharectomy 显示文摘 | Foresta C Schipilliti M De Toni L | 2011 | J Trauma2011，70，2： | 1 |
| 13 | Calcium antagonists in ischemic stroke显示文摘 | Fieschi C Argentino C Toni D | 1988 | J Cardiovasc Pharmacol1988，12，6： | 1 |
| 14 | Incidence and 10-year survival of in- traeerebral hemorrhage in a population-based registry 显示文摘 | Sacco S Marini C Toni D | 2009 | Stroke2009，40，2： | 1 |
| 15 | Release rate profiles of theophylline and insulin from stable multiple w/o/w emulsions显示文摘 | Mohammed L C Tony L W | 1997 | J Controlled Release1997，49，： | 1 |
| 16 | Structural Redundancy Evaluation of Steel Tub Girder Bridges显示文摘 | C Tony Hunley Issam E Harik | 2012 | Bridge Engi- neering ASCE2012，17，3： | 1 |
| 17 | Acute syndesmosis injuries associated withankle fractures显示文摘 | Jason C Tony M Mclaurin | 2009 | Bulletin of the NYU Hospital for Joint Diseases2009，1，： | 1 |
| 18 | Active contours without edges显示文摘 | Tony F C Luminita A V | 2001 | IEEE Transactions on Image Processing2001，10，2： | 1 |
| 19 | Fouling in membrane bioreactors used in wastewater treatment显示文摘 | Pierre L C C Tony A G F | 2006 | Membrane Science2006，284，34： | 1 |
| 20 | Available transfer capability calculations显示文摘 | Ejebe G C Toni J Waight I G | 1998 | IEEE Transactions on Power Systems1998，13，4： | 1 |
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