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| 1 | 贵州贞丰烂泥沟卡林型金矿床含砷黄铁矿Re-Os同位素测年及地质意义显示文摘贵州贞丰烂泥沟金矿(现称锦丰金矿)是滇黔桂“金三角”已知最大的卡林型金矿床,矿体赋存于断层破碎带内,最主要的载金矿物是具环带结构的含砷黄铁矿。本文运用Re-Os同位素法对该矿床的9个含砷黄铁矿样品进行了两次测试,成功获得10-9~10-12级Re-Os同位素数据:Re0.1257~1.233ng/g,Os6.75~33.50pg/g,等时线年龄为193±13Ma,反映其成矿时代为早侏罗世。等时线的初始n(187Os)/n(188Os)值为1.127±0.043,指示成矿物质来源于地壳而不是地幔。结合其他资料,初步建立其成矿模式为:盆地流体不断地从沉积物中萃取出包括金在内的成矿组分,形成含矿流体。印支期挤压造山期间,含矿流体沿不整合接触面和同生断层向上运动,造山后的伸展含矿流体进入减压扩容空间沉淀形成超大型金矿床。成矿作用发生在从印支期挤压造山向燕山期伸展转变的构造转换期。该模式与本文得到的成矿年龄和初始比值相吻合。 | 陈懋弘 毛景文 屈文俊 吴六灵 Phillip J.UTTLEY Tony NORMAN 郑建民 秦运忠 | 2007 | 地质论评2007，53，3： | 84 |
| 2 | Regulation of chromatin by histone modifications显示文摘染色质不是惰性的结构,而是能对外部暗示作出回应调整 DNA 的许多使用的有启发性的 DNA 脚手架。在这条规定起一个关键作用的染色质的一个原则部件是 histones 的修正。有这些修正的一张曾经成长的表,他们的行动的复杂性开始仅仅仅仅正在理解。然而, histone 修正在涉及 DNA 的操作和表达式的很生物的进程起基本作用,是清楚的。这里,我们描述已知的 histone 修正,定义他们在哪儿 genomically 被发现并且讨论一些他们的功能的后果,主要专注于描述的多数发生了的抄写。 | Andrew J Bannister Tony Kouzarides | 2011 | Cell Research2011，21，3： | 178 |
| 3 | 中国间变性淋巴瘤激酶(ALK)阳性非小细胞肺癌诊断专家共识(2013版)显示文摘随着分子医学进展和靶向药物的不断涌现,晚期非小细胞肺癌(NSCLC)的治疗已进入到个体化治疗的时代.目前临床应用的个体化靶向治疗主要针对表皮生长因子受体(EGFR)基因突变性和间变性淋巴瘤激酶(ALK)融合基因阳性肺癌,这两种基因变异型肺癌均具有明确的分子靶点、靶点检测技术及上市的靶向药物,临床疗效得到明显提高. | 张绪超 陆舜 张力 王长利 程颖 李甘地 Tony Mok Mok 黄诚 刘晓晴 王洁 王孟昭 张沂平 周建英 周晓燕 林冬梅 杨衿记 李慧 陈海泉 钟文昭 吴一龙 | 2013 | 中华病理学杂志2013，42，6： | 93 |
| 4 | 植物表型组学:发展、现状与挑战显示文摘随着遥感、机器人技术、计算机视觉和人工智能的发展,植物表型组学研究已经步入了快速成长阶段。本文首先介绍了植物表型组学的发展简史,包括其理论核心、研究方法、在生物研究中的应用以及国际上最新的研究动向。然后,针对各类表型技术载体平台如手持、人载、车载、田间实时监控、大型室内外自动化平台和航空机载等,分析这些技术手段在室内、外植物研究中的应用情况和实际问题。为了对表型研究中产生的巨量图像和传感器数据进行量化分析,把大数据转化为有实际意义的性状信息和生物学知识,本文着重讨论了后期表型数据解析和相应的研发过程。最后,提出表型组学的应用前景与未来展望,以期为中国的表型研究提供指导和建议。 | 周济 Francois Tardieu Tony Pridmore John Doonan Daniel Reynolds Neil Hall Simon Griffiths 程涛 朱艳 王秀娥 姜东 丁艳锋 | 2018 | 南京农业大学学报2018，41，4： | 64 |
| 5 | 贵州锦丰(烂泥沟)超大型金矿床构造解析及构造成矿作用显示文摘在矿区大比例尺填图的基础上,运用构造解析的理论和方法,对贵州锦丰(烂泥沟)金矿的构造特征、构造演化和构造控矿作用进行了系统的阐述。矿区构造线主要分为近NS向、NW向和NE向3组,其中NW向构造线控制了矿区的构造格架。构造变形主要经历了同生期裂陷、造山期挤压、后碰撞造山侧向挤压和岩石圈伸展等4个阶段。盆地裂陷期间(D2-T2)形成的同生断层为后续的构造活动提供了最初的构造薄弱面,并成为主要的热液通道;造山期挤压期间(T3)形成了矿区最为明显的近NS向和NW向大型倒转褶皱和逆冲断层以及配套的NE向右旋走滑断层;后碰撞造山侧向挤压期间(J1)形成走向NE的叠加褶皱,并在F2-F3'X'型断裂系上形成近EW向的拉张区,矿质沿着拉张的空间沉淀就位;燕山期(J2-K)岩石圈伸展,形成小规模的近水平逆断层。上述4个主要构造变形阶段与右江盆地的裂陷-闭合-坍塌的发展演化历史相吻合,成矿发生在由挤压向拉张过渡的构造体制转换阶段。造山期逆冲作用形成的构造闭圈和后碰撞造山期间挤压向伸展转变的过程中形成的局部张性构造环境是矿质得以大量聚集、沉淀的主要构造控制因素。构造成矿作用是锦丰(烂泥沟)金矿单一矿体垂向延深1000m以上的主要制约因素。构造成矿的观点将为在滇黔桂'金三角'卡林型金矿带的深部找矿提供重要的理论依据。 | 陈懋弘 毛景文 Phillip J.Uttley Tony Norman 吴六灵 郑建民 秦运忠 | 2007 | 矿床地质2007，26，4： | 51 |
| 6 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 7 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 8 | Use of portal pressure studies in the management of variceal haemorrhage显示文摘Portal hypertension occurs as a complication of liver cirrhosis and complications such as variceal bleeding lead to significant demands on resources. Endoscopy is the gold standard method for screening cirrhotic patients however universal endoscopic screening may mean a lot of unnecessary procedures as the presence of oesophageal varices is variable hence a large time and cost burden on endoscopy units to carry out both screening and subsequent follow up of variceal bleeds. A less invasive method to identify those at high risk of bleeding would allow earlier prophylactic measures to be applied. Hepatic venous pressure gradient (HVPG) is an acceptable indirect measurement of portal hypertension and predictor of the complications of portal hypertension in adult cirrhotics. Varices develop at a HVPG of 10-12 mmHg with the appearance of other complications with HPVG > 12 mmHg. Variceal bleeding does not occur in pressures under 12 mmHg. HPVG > 20 mmHg measured early after admission is a significant prognostic indicator of failure to control bleeding varices, indeed early transjugular intrahepatic portosystemic shunt (TIPS) in such circumstances reduces mortality significantly. HVPG can be used to identify responders to medical therapy. Patients who do not achieve the suggested reduction targets in HVPG have a high risk of rebleeding despite endoscopic ligation and may not derive significant overall mortality benefit from endoscopic intervention alone, ultimately requiring TIPS or liver transplantation. Early HVPG measurements following a variceal bleed can help to identify those at risk of treatment failure who may benefit from early intervention with TIPS. Therefore, we suggest using HVPG measurement as the investigation of choice in those with confirmed cirrhosis in place of endoscopy for intitial variceal screening and, where indicated, a trial of B-blockade, either intravenously during the initial pressure study with assessment of response or oral therapy with repeat HVPG six weeks later. In those with elevated pressures, primary medical prophylaxis could be commenced with subsequent close monitoring of HVPG thus negating the need for endoscopy at this point. All patients presenting with variceal haemorrhage should undergo HVPG measurement and those with a gradient greater than 20 mmHg should be considered for early TIPS. By introducing portal pressure studies into a management algorithm for variceal bleeding, the number of endoscopies required for further intervention and follow up can be reduced leading to significant savings in terms of cost and demand on resources. | Jennifer Addley Tony CK Tham William Jonathan Cash | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 37 |
| 9 | Exploitation of Fenton and Fenton-like reagents as alternative conditioners for alum sludge conditioning显示文摘The use of Fenton's reagent(Fe2+/H2O2) and Fenton-like reagents containing transition metals of Cu(II) ,Zn(II) ,Co(II) ,and Mn(II) for an alum sludge conditioning to improve its dewaterability was investigated. The results obtained were compared with those obtained from conditioning the same alum sludge using cationic and anionic polymers. Experimental results show that Fenton's reagent was the best among the Fenton and Fenton-like reagents for the alum sludge conditioning. A considerable effiectiveness of capillary suction time(CST) reduction efflciency of 47% can be achieved under test conditions of Fe2+/H2O2 = 20/125 mg/g DS(dry solid) and pH 6.0. The observation of floc-like particles after Fenton's reagent conditioning of alum sludge suggested that the mechanism of Fenton's reagent conditioning was different from that of polymer conditioning. In spite of the lower efflciency in the CST reduction of Fenton's reagent in alum sludge conditioning compared to that of polymer conditioning,Fenton's reagent o?ers a more environmentally safe option. This study provided an example of proactive treatment engineering,which is aimed at seeking a safe alternative to the use of polymers in sludge conditioning towards achieving a more sustainable sludge management strategy. | Maha A. Tony Y. Q. Zhao Aghareed M. Tayeb | 2009 | Journal of Environmental Sciences2009，21，1： | 26 |
| 10 | 中国间变性淋巴瘤激酶阳性、ROS1阳性非小细胞肺癌诊疗指南显示文摘原发性肺癌(简称肺癌)是我国最常见的恶性肿瘤之一。根据国家癌症中心公布的2015年癌症统计数据显示,2015年,我国新发肺癌患者例数达73.3万,死亡例数60.0万。居所有恶性肿瘤之首,其中80%以上的患者为非小细胞肺癌(non—small cell lung cancer)。 | 张绪超 陆舜 黄诚 刘晓晴 杨衿记 宋勇 张力 廖美琳 王长利 程颖 李甘地 Tony Mok 莫树锦 王洁 王孟昭 张沂平 周建英 周晓军 周晓燕 林冬梅 胡成平 王凯 何勇 李慧 钟文昭 吴一龙 | 2018 | 中华病理学杂志2018，47，4： | 26 |
| 11 | Update on hepatocellular carcinoma: Pathologists' review显示文摘Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma(HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC.Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC:Steatohepatitic, clear cell, fibrolamellar and scirrhous-and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed. | Tony El Jabbour Stephen M Lagana Hwajeong Lee | 2019 | World Journal of Gastroenterology2019，25，14： | 25 |
| 12 | Risk factors and outcome of bacterial infections in cirrhosis显示文摘Viable and non-viable pathological bacterial translocation promote a self-perpetuating circle of dysfunctional immune activation and systemic inflammation facilitating infections and organ failure in advanced cirrhosis.Bacterial infections and sepsis are now recognized as a distinct stage in the natural progression of chronic liver disease as they accelerate organ failure and contribute to the high mortality observed in decompensated cirrhosis.The increasing knowledge of structural,immunological and hemodynamic pathophysiology in advanced cirrhosis has not yet translated into significantly improved outcomes of bacterial infections over the last decades.Therefore,early identification of patients at the highest risk for developing infections and infectionrelated complications is required to tailor the currently available measures of surveillance,prophylaxis and therapy to the patients in need in order to improve the detrimental outcome of bacterial infections in cirrhosis. | Tony Bruns Henning W Zimmermann Andreas Stallmach | 2014 | World Journal of Gastroenterology2014，20，10： | 24 |
| 13 | IEC 61850应用于分布式馈线自动化系统的模型显示文摘远传型故障指示器或功能模块可以检测配电线路各区段的故障并上传检测结果,从而为分布式馈线自动化(FA)进行故障区间定位提供判断依据。以IEC 61580-90-6技术报告所提出的故障指示功能为基础,构建基于IEC 61850的分布式馈线自动化的系统模型,提出了分布式故障区间定位、隔离和供电恢复的逻辑节点。扩展现有的IEC 61850系统配置语言(SCL)模型以描述配电网的一次拓扑和逻辑功能配置。给出IEC 61850应用于馈线自动化系统的通信服务映射。最后,提出了变电站自动化和馈线自动化系统进行数据交换的配置流程。通过应用示例表明,所提出的IEC 61850信息模型可以支持分布式馈线自动化功能和终端之间的互操作。 | 朱正谊 徐丙垠 Tony YIP 陈羽 于强强 李妍 | 2018 | 电力系统自动化2018，42，23： | 22 |
| 14 | Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses显示文摘Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice versa.This review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases. | Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang Meihua Wan Tony Y.Hu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 22 |
| 15 | 贵州锦丰(烂泥沟)金矿床含砷黄铁矿和脉石英及其包裹体的稀土元素特征显示文摘贵州锦丰(烂泥沟)金矿是滇黔桂'金三角'目前已探明的最大的卡林型金矿床。含砷黄铁矿是该矿床最主要的载金矿物,脉石英是最显著的热液蚀变作用产物。含砷黄铁矿、脉石英及其包裹体具有相同的稀土元素特征,表现为轻重稀土分馏明显(LREE/HREE:7.95~31.77,(La/Yb)_N:8.97~40.49);轻稀土有一定的分异((La/Sm)_N:3.20~5.29),曲线右倾程度大;重稀土分异不明显((Gd/Yb)_N:1.41~3.35),曲线平坦;负铕异常明显(δEu 0.59~0.71);微弱的铈负异常(δCe 0.97~0.98)。代表成矿流体特征的脉石英包裹体稀土配分型式及特征值与区域上不同时代的幔源基性-超基性岩差别较大,而与矿床围岩、矿石、含砷黄铁矿及其包裹体稀土配分型式及特征值十分相似,具上部地壳普通沉积岩的特点,反映成矿流体主要不是来源于地幔,而是以壳源为主。Eu负异常反映了偏酸性(富CO_2)、还原性的成矿环境;微弱的Ce负异常表明成矿流体来源于以沉积水和热脱水为主的盆地流体。 | 陈懋弘 吴六灵 Phillip J.Uttley Tony Norman 郑建民 秦运忠 | 2007 | 岩石学报2007，23，10： | 21 |
| 16 | A different spectrum of DMD gene mutations in local Chinese patients with Duchenne/Becker muscular dystrophy显示文摘背景 Duchenne 肌肉发达的营养障碍(DMD ) 和贝克尔肌肉发达的营养障碍(BMD ) 是 X 连接后退的、突变而产生之遗传的混乱。这研究被进行与 Duchenne 或贝克尔在香港中国病人调查 DMD 基因变化的光谱,并且学习遗传型显型肌肉发达的营养障碍(DMD/BMD ) 关联。67 个病人的方法 Aretrospective 评论。结果 23 (34.3%) 病人们在删除上有前;而 5 (7.5%) 病人们在复制上有前。23 (34.3%) 病人们有小变化,包括 17 个点变化和 6 小插入或删除。没有关联在变化和肌肉显型或智力迟钝的类型之间被发现。显著地,更少母亲的搬运人在删除上与前在病人被发现,并且积极家庭历史在有小变化的那些是更普通的。DMD 显型是显著地不在有在 5'' 热点的 exondeletions/duplications 的病人普通,而与智力迟钝联系的所有 4 个小变化位于 3'' ,基因结束。结论在本地中国病人的 DMD exondeletions 的百分比比显著地低通常引用了 60% 。Thisindicated 在到删除上的 DMD 前的倾向的种族或地区性的差别。 | Ivan Fai-man Lo Kent Keung-san Lai Tony Ming-for Tong Stephen Tak-sum Lam | 2006 | Chinese Medical Journal2006，，13： | 21 |
| 17 | 天坑释义显示文摘天坑是一种特大型塌陷漏斗,它的演化包括大型洞穴厅堂的洞顶崩塌和大型暗河对大量崩塌块石的搬运。天坑这个术语,首先在中国使用,随后成为世界性的喀斯特词汇。 | 朱学稳 Tony WALTHAM 朱学稳(著译) 张远海(校) | 2006 | 中国岩溶2006，25，B08： | 20 |
| 18 | 对政府绩效的满意度:中国农村和城市的民意调查 | Tony Saich | 2006 | 公共管理评论2006，，2： | 19 |
| 19 | The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects显示文摘Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell proliferation.In late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line therapy.Unfortunately,the development of drug resistance to sorafenib is becoming increasingly common.This study aims to identify factors contributing to resistance and ways to mitigate resistance.Recent studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression.This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients. | Weiwei Tang Ziyi Chen Wenling Zhang Ye Cheng Betty Zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 19 |
| 20 | 基于换电和电池租赁模式的纯电动汽车运营成本评估及预测研究显示文摘在纯电动汽车示范运营中,动力电池运营价格测算是开展电池租赁模式的重要前提,目前尚无成熟方法并缺少可靠数据。本文运用成本加成定价法和年金法,在裸车销售,电池租赁模式下,在充换电站建设、运营和电池租赁由两个主体承担的条件下,对电池运营价格进行了测算;同时,应用影响因素敏感性分析方法,结合北京市纯电动公交车实际运营数据,分析了电池系统价格、贴现率、年人工成本、年充电量和充电基础设施初期投资等因素对动力电池运营价格的影响,得出电池价格和充电量是影响运营价格的最敏感因素。根据连续4年的小型成熟二次锂电池价格历史数据和燃油价格趋势,预测并比较了未来几个四年电动汽车和传统汽车的运营费用,最终提出了未来电动汽车产业发展的建议。 | 孙丙香 何婷婷 牛军龙 张维戈 姜久春 Tony Yip | 2014 | 电工技术学报2014，29，4： | 18 |
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