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| 1 | Probiotic Medilac-S^(█) for the induction of clinical remission in a Chinese population with ulcerative colitis: A systematic review and meta-analysis显示文摘AIM To assess the effects of probiotic Medilac-S~ as adjunctive therapy for the induction of remission of ulcerative colitis(UC) in a Chinese population through a systematic review and meta-analysis. METHODS A systematic literature search was conducted to find randomized, controlled trials in a Chinese population with at least two study arms-a control arm which receives a conventional, oral aminosalicylate drug, and a treatment arm, which administers the same conventional drug in conjunction with the probiotic Medilac-S~ per os. Both English and Chinese databases were searched, including Pub Med, EMBASE, Google Scholar, Chinese National Knowledge Infrastructure, Wanfang Data, and VIP Search, and study data was extracted onto standardized abstraction sheets. Meta-analyses were conducted for primary and secondary outcomes of interest using a fixed or random effects model. The primary outcome was the induction of clinical remission and the secondary outcomes included changes in Sutherland index, endoscopic and histological scores, proportion of reported clinical symptoms and adverse events(AEs). For outcomes with sufficient data, the type of conventional drug therapy was also assessed to determine if the effects of combination therapy with Medilac-S~ was influenced by drug type. All tests were conducted using a type Ⅰ error rate of 0.05 and all confidence intervals(CI) were based on a 95% confidence level. Review protocol was uploaded to PROSPERO(CRD42018085658 upon completion).RESULTS Fifty-three clinical trials with a total of 3984 participants were identified and included in the review. Medilac-S~ adjunctive therapy significantly improved induction of clinical remission(RR = 1.21; 95%CI: 1.18-1.24; P < 0.0001) with the estimated likelihood of effective treatment, on average, 21% higher for those consuming the probiotic. Sutherland index scores showed the control mean was on average 3.10(CI: 2.41-3.78; P = 0.0428) units greater than the treatment mean, thereby demonstrating significant improvement in participants taking the probiotic. Similarly, a significant difference was seen between the overall reduction of endoscopic and histological scores of control and treatment arm participants, with score decreases in the control groups 0.71(CI: 0.3537-1.0742) and 1.1(CI: 0.9189-1.2300) units smaller than treatment group score decreases. The proportion of participants reporting clinical symptoms,(abdominal pain, tenesmus, blood and mucous in stool, and diarrhea) was significantly reduced after combination therapy with Medilac-S~(P < 0.0001) and estimated to be on average 44%(RR = 0.44, CI: 0.32-0.59), 53%(RR = 0.53, CI: 0.38-74), 40%(RR = 0.40, CI: 0.28-0.58) and 47%(RR = 0.47 CI: 0.36-0.42) respectively, of the proportion of individuals reporting the aforementioned symptoms after conventional therapy alone. The risk of AEs was also significantly reduced with adjunctive Medilac-S~ therapy. The proportion of individuals in the treatment groups reporting AEs was an estimated 72% of the proportion of individuals in the control groups reporting AEs(RR = 0.72, CI: 0.55-0.94, P = 0.0175). Upon comparing effect means for different drug types in conjunction with Medilac-S~, evidence of significant variability(P < 0.0001) was observed, and sulfasalazine was found to be the most effective drug in both primary and secondary outcomes. CONCLUSION Evidence suggests Medilac-S~ adjunctive therapy should be considered standard care for UC in a Chinese population because it aids in the induction of clinical remission, improves symptoms of the gastrointestinal tract and reduces risk of AEs. | Ghania Sohail Xiaoyu Xu Mary C Christman Thomas A Tompkins | 2018 | World Journal of Clinical Cases2018，6，15： | 3 |
| 2 | Titanium nitride oxidation chemistry: An X-ray photoelectron spectroscopy study 显示文摘 | Saha N C Tompkins H G | 1992 | Journal of Applied Physics1992，72，7： | 1 |
| 3 | Titanium nitride oxidation chemistry:An x-ray photoelectron spectroscopy study 显示文摘 | SAHA N C TOMPKINS H G | 1992 | J Apply Phys1992，72，： | 1 |
| 4 | Optical properties of fire and non-fire aerosols显示文摘 | Loepfe M Ryser P Tompkin C | 1997 | Fire Safety Journal1997，29，23： | 1 |
| 5 | The distribution of iron in iron-enriched cells of Saccharomyces cerevisiae 显示文摘 | Gaudreau H Tompkins T A Champagne C P | 2001 | Acta Alimentaria2001，30，： | 1 |
| 6 | Optimal strategies for the management of antiplatelet and anticoagulation medica-tions prior to cardiac device implantation 显示文摘 | Tompkins C Henrikson CA | 2011 | Cardiol J2011，，1： | 1 |
| 7 | The metabolic syndrome in women显示文摘 | Schneider J G Tompkins C Blumenthal R S | 2006 | Cardiol Rev2006，14，： | 1 |
| 8 | Testing Turing,s theory of morphogenesis in chemical cells显示文摘 | Tompkins N Li N Girabawe C | 2014 | Proc Natl Acad Sci USA2014，111，12： | 1 |
| 9 | Postnatal development of muscle fiber types in domestic animals显示文摘 | ASHMORE C R TOMPKINS G DOERRL | 1972 | J Anim Sci1972，34，： | 1 |
| 10 | The metabolic basis of the increase in energy expenditure in severely burned patients显示文摘 | Yu YM Tompkins GRG Ryan C | 1999 | JPEN1999，23，3： | 1 |
| 11 | Mineralogy of the lunar crust: results from elementine 显示文摘 | Tompkins S Pieters C M | 1999 | Meteoritics & Planetary Science1999，34，1： | 1 |
| 12 | Are axillary recurrence and overall survival affected by axillary extranodal tumor extension in breast cancer?Implications for radiation therapy显示文摘 | Leonard C Corkill M Tompkin J | 1995 | J Clin Oncol1995，13，9： | 1 |
| 13 | Effect of fermentation by pure and mixed cultures of Streptococcus thermophilus and Lactobacillus helveticus on isoflavone and B-vitamin content of a fermented soy beverage显示文摘 | CHAMPAGNE C P TOMPKINS T A BUCKLEY N D | 2010 | Food Microbiology2010，27，7： | 1 |
| 14 | Hemiepiphyseal stapling for ankle valgus in multiple hereditary exostoses显示文摘 | Tompkins M Eberson C Ehrlich M | | 0，，： | 1 |
| 15 | Cae+ influx, but not Ca2+ release from internal stores, is re quired for the PACaP-induced increase in excitability in guinea pig intracardiac neurons显示文摘 | Tompkins J D Hardwick J C Locknar S A Merriam L A Parsons R L | 2006 | J Neurophysiol2006，95，： | 1 |
| 16 | Effect of 5-azacytidine on gene expression in marrow stromal cells 显示文摘 | Andrews DF Nemunaitis J Tompkins C | 1989 | Mol Cell Biol1989，9，6： | 1 |
| 17 | A longitudinal study of the psychosocial impact of stroke on primary support persons显示文摘 | Schulz R Tompkins C A Rau M T | 1988 | Psychol Aging1988，3，2： | 1 |
| 18 | A longitudinal study of the psy-chosocial impact of stroke on primary support persons显示文摘 | Schulz R Tompkins C A Rau M | 1988 | Psychol Aging1988，3，： | 1 |
| 19 | Determination of calibration constants for the hole-drilling residual stress measurement technique applied to orthotropic composites-Part Ⅰ:Theoretical considerations显示文摘 | Prasad C B Prabhakaran R Tompkins S | 1987 | Compos Struct1987，8，2： | 1 |
| 20 | Matrix pro tein 2 vaccination and protection against influenza viruses, including subtype H5N1 显示文摘 | Tompkins S M Zhao Z S Lo C Y | 2007 | Emerg Infect Dis2007，13，3： | 1 |
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