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| 1 | Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial显示文摘AIM: To determine the efficacy of rectally administered naproxen for the prevention of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS: This double-blind randomized control trial conducted from January 2013 to April 2014 at the Gastrointestinal and Liver Diseases Research Center in Rasht, Iran. A total of 324 patients were selected from candidates for diagnostic or therapeutic ERCP by using the simple sampling method. Patients received a single dose of Naproxen(500 mg; n = 162) or a placebo(n = 162) per rectum immediately before ERCP. The overall incidence of PEP, incidence of mild to severe PEP, serum amylase levels and adverse effects were measured. The primary outcome measure was the development of pancreatitis onset of pain in the upper abdomen and elevation of the serum amylase level to > 3 × the upper normal limit(60-100 IU/L) within 24 h after ERCP. The severity of PEP was classified according to the duration of therapeutic intervention for PEP: mild, 2-3 d; moderate 4-10 d; and severe, > 10 d and/or necessitated surgical or intensive treatment, or contributed to death.RESULTS:PEP occurred in 12 %(40/324) o f participants, and was significantly more frequent in the placebo group compared to the naproxen group(P < 0.01). Of the participants, 25.9%(84/324) developed hyperamylasemia within 2 h of procedure completion, among whom only 35 cases belonged to the naproxen group(P < 0.01). The incidence of PEP was significantly higher in female sex, in patients receiving pancreatic duct injection, more than 3 times pancreatic duct cannulations, and ERCP duration more than 40 min(P s < 0.01). There were no statistically significant differences between the groups regarding the procedures or factors that might increase the risk of PEP, sphincterotomy, precut requirement, biliary duct injection and number of pancreatic duct cannulations. In the subgroup of patients with pancreatic duct injection, the rate of pancreatitis in the naproxen group was significantly lower than that in the placebo(6 patients vs 23 patients, P < 0.01, RRR = 12%, AR = 0.3, 95%CI: 0.2-0.6). Naproxen reduced the PEP in patients with ≥ 3 pancreatic cannulations(P < 0.01, RRR = 25%, AR = 0.1, 95%CI: 0.1-0.4) and an ERCP duration > 40 min(P < 0.01, RRR = 20%, AR = 0.9, 95%CI: 0.4-1.2).CONCLUSION: Single dose of suppository naproxen administered immediately before ERCP reduces the incidence of PEP. | Fariborz Mansour-Ghanaei Farahnaz Joukar Zahra Taherzadeh Homayoon Sokhanvar Tolou Hasandokht | 2016 | World Journal of Gastroenterology2016，22，21： | 4 |
| 2 | Delivery of RNAi mediators显示文摘 | Ford L P Toloue M M | 2010 | Wiley Interdiscip Rev RNA2010，1，： | 1 |
| 3 | Ebola vires hemorrhagic fever: another deadly strike in Sudan显示文摘 | ThillM Tolou H | 2004 | Med Trop (Mars)2004，64，4： | 1 |
| 4 | Bistable vibration energy harvesters: a review 显示文摘 | Pellegrini S P Tolou N Schenk M | 2013 | Journal of Intelligent Material Systems and Structures2013，24，1： | 1 |
| 5 | Ebola virus hemorrhagic fever: another deadly strike in Sudan显示文摘 | Thill M Tolou H | 2004 | Med Trop(Mars)2004，64，4： | 1 |
| 6 | Nanocomposite materials in orthopedic applications显示文摘This chapter is an introduction to nanocomposite materials and its classifications with emphasis on orthopedic application. It covers different types of matrix n anocomposites in eluding ceramics, metal, polymer and natural-based nanocomposites with the main features and applications in the orthopedic. In addition, it presents structure, composition, and biomechanical features ofbone as a natural nanocomposite. Finally, it deliberately presents developing methods for nanocomposites bone grafting. | Mostafa R.Shirdar Nasim Farajpour Reza Shahbazian-Yassar Tolou Shokuhfar | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 1 |
| 7 | Marburg Ⅰ polymorphism of factor Ⅶ- activating protease is associated with idiopathic venous thromboembolism 显示文摘 | Hoppe B Tolou F Radtke H | 2005 | Blood2005，105，4： | 1 |
| 8 | High variability of peptidylarginine deiminase 4 (PADI4) in a healthy white population: characterization of six new variants of PADI4 exons 2–4 by a novel haplotype-specific sequencing-based approach显示文摘 | Berthold Hoppe Guido A. Heymann Farzaneh Tolou Holger Kiesewetter Thomas Doerner Abdulgabar Salama | 2004 | Journal of Molecular Medicine2004，，11： | 1 |
| 9 | Evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome sequences显示文摘 | Tolou H J Couissinier P Durand J P | 2001 | J Gen Virol2001，82，： | 1 |
| 10 | Evidence for re-combination in natural populations of dengue virus type 1 based on theanalysis of complete genome sequences显示文摘 | Tolou H J G Couissinier-Paris P Durand J P | 2001 | J Gen Virol2001，82，6： | 1 |
| 11 | The unexpected Chikungunya outbreak 显示文摘 | Simon F Tolou H Jeandel P | 2006 | Rev Med Interne2006，27，6： | 1 |
| 12 | Evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome sequences显示文摘 | Tolou H J Couissinier P Durand JP | 2001 | J Gen Virol2001，82，： | 1 |
| 13 | Evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome sequences显示文摘 | Tolou H J Couissinier Paris P Durand J P | 2001 | J Gen Virol2001，82，6： | 1 |
| 14 | Position tracking of a 3-PSP parallel robot using dynamic growing interval type-2 fuzzy neural control显示文摘 | TOLOUE S F AKBARZADEH M R AKBARZADEH M A | 2015 | Applied Soft Computing2015，37，12： | 1 |
| 15 | Evidence for recombination in natural popu- lations of dengue virus type 1 based on the analysis of complete genome sequenees显示文摘 | TOLOU H J COUISSINIER-PARIS P DURAND J P | 2001 | J Gen Virol2001，82，6： | 1 |
| 16 | Evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome sequences显示文摘 | Tolou HJG Couissiner-Paris P Durand J-P | 2001 | J Gen Viro2001，82，： | 1 |
| 17 | Clinical burden of chikungunya virus infection 显示文摘 | Queyriaux B Simon F Grandadam M Michel R Tolou H Boutin JP | 2008 | Lancet Infect Dis2008，8，1： | 1 |
| 18 | Clinical burden of chikungunya virus infection显示文摘 | Benjamin Queyriaux Fabrice Simon Marc Grandadam Rémy Michel Hugues Tolou Jean-Paul Boutin | 2008 | The Lancet Infectious Diseases2008，，1： | 1 |
| 19 | A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012 显示文摘 | Tolou - Ghamari Z Zare M Habibabadi JM | 2013 | JResMedSci2013，，： | 1 |
| 20 | Bi- stable vibration energy harvesters : A review 显示文摘 | PELLEGRINI S P TOLOU N SCHENK M | 2012 | Journal of Intelligent Material Systems and Structures2012，24，11： | 1 |
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