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| 1 | Esophageal testing: What we have so far显示文摘Gastroesophageal reflux disease(GERD) is a common disorder of the gastrointestinal tract. In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of GERD. High-resolution manometry(HRM) permits greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. Moreover, HRM has been found to be more reproducible and sensitive than conventional water-perfused manometry to detect the presence of transient lower esophageal sphincter relaxation. Esophageal 24-h p H-metry with or without combined impedance is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and p H monitoring can detect acid and non-acid reflux events. Endo FLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. In the coming years, laryngopharyngeal symptoms could be evaluated with up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal p H-metry. Future studies are required of these techniques to evaluate their diagnostic accuracy and usefulness, although the available data are promising. | Nicola de Bortoli Irene Martinucci Lorenzo Bertani Salvatore Russo Riccardo Franchi Manuele Furnari Salvatore Tolone Giorgia Bodini Valeria Bolognesi Massimo Bellini Vincenzo Savarino Santino Marchi Edoardo Vincenzo Savarino | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 8 |
| 2 | Costs of laparoscopic and open liver and pancreatic resection:A systematic review显示文摘AIM:To study costs of laparoscopic and open liver and pancreatic resections,all the compiled data from available observational studies were systematically reviewed.METHODS:A systematic review of the literature was performed using the Medline,Embase,Pub Med,and Cochrane databases to identify all studies published up to 2013 that compared laparoscopic and open liver[laparoscopic hepatic resection(LLR)vs open liver resection(OLR)]and pancreatic[laparoscopic pancreatic resection(LPR)vs open pancreatic resection]resection.The last search was conducted on October 30,2013.RESULTS:Four studies reported that LLR was associated with lower ward stay cost than OLR(2972 USD vs 5291 USD).The costs related to equipment(3345USD vs 2207 USD)and theatre(14538 vs 11406)were reported higher for LLR.The total cost was lower in patients managed by LLR(19269 USD)compared to OLR(23419 USD).Four studies reported that LPR was associated with lower ward stay cost than OLR(6755vs 9826 USD).The costs related to equipment(2496USD vs 1630 USD)and theatre(5563 vs 4444)were reported higher for LPR.The total cost was lower in the LPR(8825 USD)compared to OLR(13380 USD).CONCLUSION:This systematic review support the economic advantage of laparoscopic over open approach to liver and pancreatic resection. | Paolo Limongelli Chiara Vitiello Andrea Belli Madhava Pai Salvatore Tolone Gianmattia del Genio Luigi Brusciano Giovanni Docimo Nagy Habib Giulio Belli Long Richard Jiao Ludovico Docimo | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 3 | Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors显示文摘Gastroesophageal reflux disease(GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors(PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD. Outcomes described in current literature following laparoscopic fundoplication indicate that it is highly effective for treatment of GERD; early clinical studies demonstrate relief of symptoms in approximately 85%-90% of patients. However it is still unclear which factors, clinical or instrumental, are able to predict a good outcome after surgery. Virtually all demographic, esophagogastric junction anatomic conditions, as well as instrumental(such as presence of esophagitis at endoscopy, or motility patterns determined by esophageal high resolution manometry or reflux patterns determined by means of pH /impedance-pH monitoring) and clinical features(such as typical or atypical symptoms presence) of patients undergoing laparoscopic fundoplication for GERD can be factors associated with symptomatic relief. With this in mind, we sought to review studies that identified the factors that predict outcome after laparoscopic total fundoplication. | Salvatore Tolone Giorgia Gualtieri Edoardo Savarino Marzio Frazzoni Nicola de Bortoli Manuele Furnari Giuseppina Casalino Simona Parisi Vincenzo Savarino Ludovico Docimo | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 3 |
| 4 | Total thyroidectomy with- out prophylactic central neck dissection combined with routine oral calcium and vitamin D supplements: is it a good option to achieve a low recurrence rate avoiding hypocalcemia? A retrospective study 显示文摘 | Docimo G Tolone S Ruggiero R | 2013 | Minerva Chir2013，68，3： | 1 |
| 5 | Virtual situation rooms:connecting people across enterprises for supply-chain agility显示文摘 | TOLONE W J | | 0，，： | 1 |
| 6 | The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB (2) and adenosine receptors显示文摘 | Castillo A Tolon M R Fernandez-Ruiz J | | 0，，2： | 1 |
| 7 | An integrated methodology for critical infrastructure modeling and simulation 显示文摘 | TOLONE W LEE S W XIANG Wei-ning | 2009 | Critical Infrastructure Protection Ⅱ The International Federation for Information Processing2009，290，： | 1 |
| 8 | Total thyroidectomy with- out prophylactic central neck dissection combined with routine oral calcium and vitamin D supplements: is it a good option to achieve a low recurrence rate avoiding hypocalcenfia? A retrospective study 显示文摘 | Docimo G Tolone S Ruggiero R | 2013 | Minerva Chir2013，68，3： | 1 |
| 9 | Access control in collaborative systems显示文摘 | TOLONE W AHN G J PAl T | 2005 | ACM Computing Surveys2005，，： | 1 |
| 10 | Seismic reliability assessment of a two-story steel-concrete composite frame designed according to Eurocode 8 显示文摘 | PILUSO V RIZZANO G TOLONE I | 2009 | Structural Safety2009，31，： | 1 |
| 11 | Carmabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains 显示文摘 | Benito C Nunez E Tolon RM | 2003 | J Neurosci2003，23，11： | 1 |
| 12 | Role of pre and post-operative oral calcium and vitamin D supplements in prevention of hypocalcemia after total thyroidectomy显示文摘 | Docimo G Tolone S Pasquali D | 2012 | G Chir2012，33，1112： | 1 |
| 13 | Impact of total fundopli-cation on esopHageal transit : analysis by combined multichannelintraluminal impedance and manometry 显示文摘 | Del Genio G Tolone S Del Genio F | 2012 | J Clin Gastroenterol2012，46，1： | 1 |
| 14 | Role of pre and post-operative oral Calcium and Vitamin D supplements in prevention of hypocalcemia after total thyroidectomy 显示文摘 | Docimo G Tolone S Pasquali D | 2012 | G Chir2012，33，1112： | 1 |
| 15 | Cannabinoid CB1 Receptors Are Expressed by Parietal Cells of the Human Gastric Mueosa显示文摘 | Pazos M R Tolon R M Benito C | 2008 | J Histochem Cytochem2008，56，5： | 1 |
| 16 | Discriminatory power and usefulness of pulsed field gel electrophoresis in epidemiologicat studies of Pseudomonas aeruginosa显示文摘 | Tolon D Cailleaux V Thouverez M | 1996 | J Hosp Infect1996，32，2： | 1 |
| 17 | Impact of total fundoplication on esophageal transit: analysis by combined multichannel intraluminal impedance and manometry显示文摘 | Del Genio G Tolone S Del Genio F | 2012 | J Clin Gastroenterol2012，46，1： | 1 |
| 18 | Physiological and productive responses of environmental control on housed sows显示文摘 | Romanini C E B Tolon Y B Naas I A et aI | 2008 | Scientia Agricola2008，65，4： | 1 |
| 19 | Sleeve gastrectomy and de- velopment of 'de novo' gastroesophageal reflux显示文摘 | Del Genio G Tolone S Limongelli P | 2014 | Obes Surg2014，24，1： | 1 |
| 20 | The activa-tion of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macro- phages显示文摘 | Tolon RM Nunez E Pazos MR | 2009 | Brain Res2009，1283，： | 1 |
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