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| 1 | Clinical outcomes of 25-gauge vitrectomy surgery for vitreoretinal diseases: comparison of vitrectomy alone and phaco-vitrectomy显示文摘AIM: To compare the clinical outcomes of combined25-gauge pars plana vitrectomy(PPV) and phacoemulsification/posterior chamber intraocular lens(PC-IOL) implantation with vitrectomy alone surgery in patients with various vitreoretinal diseases.METHODS: A total of 306 eyes(145 with PPV alone and 161 with phaco-vitrectomy) were enrolled in this retrospective analysis. The surgical approach was 25-gauge PPV combined with phacoemulsification and PC-IOL implantation at the same time in eyes in phaco-vitrectomy group and only PPV in eyes in vitrectomy alone surgery group. The main outcome measures were postoperative clinical outcomes included anterior chamber inflammation, changes in intraocular pressure(IOP) and best corrected visual acuity(BCVA).RESULTS: The most common postoperative complication was anterior chamber reaction which has higher incidence in phaco-vitrectomy group(P <0.001).The mean postoperative 1^(st) day IOP of vitrectomy alone group was significantly lower than that of phaco-vitrectomy group(16.3 ±5.8 mm Hg vs 17.8 ±8.1 mm Hg,respectively, P =0.02). Hypotony(IOP(8 mm Hg) was not different between groups in the postoperative 1^(st) day(P >0.05). The mean preoperative visual acuity was not different between groups(1.6±0.9 log MAR vs 1.8±0.9 log MAR,respectively, P >0.05). However, the mean visual acuity was decreased in vitrectomy alone group at the final visit compared to phaco-vitrectomy group(1.2 ±0.8 log MAR,0.9±0.7 log MAR, respectively P <0.05).CONCLUSION: Twenty-five gauge PPV combined with phacoemulsification surgery is a safe and efficient procedure, which can be preferred in phacic patients with a variety of vitreoretinal diseases compared to vitrectomy alone. Despite improved outcomes, this approach is not free of limitations as anterior chamber complications especially with combined surgery. | Mucella Arikan Yorgun Yasin Toklu Melek Mutlu Umut Ozen | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 10 |
| 2 | Short-term effects of intravitreal triamcinolone acetonide injection on ocular blood flow evaluated with color Doppler ultrasonography显示文摘AIM:To evaluate the changes in ocular blood flow with color Doppler ultrasonography(CDU) after intravitreal triamcinolone acetonide(IVTA) injection.METHODS:A total of 46 patients who underwent IVTA(4 mg/0.1 mL) injection for diabetic macular edema(DME)(n =22), central retinal vein occlusion(CRVO)(n =12) and choroidal neovascular membrane(CNVM)(n =12) were included in the study. Peak systolic velocity(PSV), end diastolic velocity(EDV) and resistivity index(RI) were measured from the ophthalmic artery(OA), the central retinal artery(CRA) and the posterior ciliary artery(PCA)of each patient with CDU before, at the end of the first week and at the end of the first month following IVTA injection.RESULTS:In the DME group, PSV of OA at the first of the first month(mean ±SD)(37.48 ±10.87 cm/s) increased compared to pre-injection value(31.39 ±10.84 cm/s)(P =0.048). There was a statistically significant decrease(P =0.049) in PSV of CRA at the end of the first month(7.97±2.67 cm/s) compared to the pre-injection(9.47±3.37 cm/s).There was not any statistically significant difference onthe other parameters in the DME group. Also, there was not any statistically significant difference on the ocular blood flow values in the CRVO and CNVM groups.CONCLUSION:We observed that 4 mg/0.1 mL IVTA increased PSV of OA and decreased PSV of CRA in DME patients and did not have any effect on ocular blood flow values of CRVO and CNVM patients. | Mustafa Alpaslan Anayol Yasin Toklu Elif Asik Kamberoglu Sabri Raza Hasan Basri Arifoglu Huseyin Simavli Ayse Gul Kocak Altintas Saban Simsek | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 4 |
| 3 | Comparison of postoperative anterior segment changes associated with pars plana vitrectomy with and without vitreous base shaving显示文摘AIM:To compare changes in anterior segment topography and axial length(AL)evaluated with Pentacam and IOL Master after pars plana vitrectomy(PPV)performed with and without vitreous base shaving.METHODS:This prospective study included patients who underwent PPV or phacoemulsification+PPV(Phaco+PPV)for various indications.Patients who underwent total posterior hyaloid detachment and excessive vitreous base shaving with scleral indentation were referred to as complete PPV(c-PPV).The patients whom posterior hyaloid was separated as far as the posterior arcades and vitreous base shaving with scleral depression was not performed were classified as the partial PPV(p-PPV)group.All patients underwent detailed ophthalmologic examinations preoperatively and lwk,I,and 3mo postoperatively.Changes in the anterior chamber depth(ACD),anterior chamber volume(ACV),iridocorneal angle(ICA)f central corneal thickness(Cd),and keratometric measurements(K1 and K2)were evaluated with Pentacam HR.Changes in the AL measurements were analyzed with IOL Master.RESULTS:A significant increase in ACD was observed in c-PPV cases(P=0.02),but this increase was not significant in the p-PPV group(P=0.053).In contrast,ICA increased significantly in the c-PPV group(P=0.02)but decreased in the p-PPV group(P=0.09).BCVA was significantly improved in the c-PPV group from week 1(P<0.001)while the increase in the p-PPV group reached significance at 3mo(P=0.035).Cd increased in the first week and later returned to baseline in both groups.No significant differences in the other parameters were observed between the groups,and there were no significant changes in intraocular pressure,ACV,AL,K1 or K2 values(P>0.05 for all).CONCLUSION:Incomplete posterior hyaloid excision and not removing the vitreous base in PPV surgeries may create a more stable anterior chamber,thus preventing the downward movement of the lens-iris diaphragm,and may cause ciliary body retraction,thereby reducing ICA.Awareness of these effects can provide some amount of guidance to physicians in selecting the appropriate PPV procedure and preempting surgical complications. | Enes Toklu Muhammed Altinisik Ahmet Elbay ArifKoytak | 2020 | International Journal of Ophthalmology(English edition)2020，13，11： | 2 |
| 4 | Meloxicam exerts neuroprotection on spinal cord trauma in rats显示文摘 | Hakan T Toklu HZ Biber N | | 0，，： | 1 |
| 5 | Ghrelin alleviates spinal cord injury in rats via its anti-inflammatory effects显示文摘 | Ersahin M Toklu HZ Erzik C | 2011 | Turk Neurosurg2011，21，4： | 1 |
| 6 | Aural barotrauma in submarine escape:is mastoid pneumatization of significance显示文摘 | Toklu AS Shupak A Yildiz S | | 0，，07： | 1 |
| 7 | Comparison of tomidate - remifentanil and propofol - remifentanil sedation in patients scheduled for colonoscopy 显示文摘 | Toklu S Iyilikei L Gonen C | 2009 | Eur J Anaesthesiol2009，26，5： | 1 |
| 8 | Topical antimicrobialsfor burn infections-an update 显示文摘 | Sevgi M Toklu A Vecchio D | 2013 | Recent Pat AntiinfectDrug Discov2013，8，3： | 1 |
| 9 | Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison meta-analysis显示文摘 | Bangalore S Toklu B Amoroso N | 2013 | BMI2013，347，： | 1 |
| 10 | The changing face of pharmacy practice and the need for a new model of pharmacy education显示文摘 | Toklu HZ Hussain A | 2013 | J Young Pharm2013，5，2： | 1 |
| 11 | Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison meta-analysis显示文摘 | Sripal Bangalore Bora Toklu Nicholas Amoroso | 2013 | BMJ2013，347，： | 1 |
| 12 | Beta-glucan protects against burn-induced oxidative organ damage in rats显示文摘 | Toklu HZ Sener G Jahovic N | 2006 | Int Immunopharmacol2006，6，2： | 1 |
| 13 | Effects of age,gender,and cognitive,functional and motor status on functional outcomes of stroke rehabilitation显示文摘 | Ones K Yalcinkaya EY Toklu BC | 2009 | Neu Rehabilitation2009，25，4： | 1 |
| 14 | Very long-term clinical fol- low-up after fractional flow reserve-guided coronary revasculariza- tion显示文摘 | Miller LH Toklu B Rauch J | 2012 | J Invasive Cardiol2012，24，7： | 1 |
| 15 | Comparison of etomidate-remifentaniiand propofol-remifentanil sedation in patients scheduled forcolonoscopy显示文摘 | Toklu S lyilikei L Gonen C | 2009 | Eur J Anaesthesiol2009，26，5： | 1 |
| 16 | Comparison of etomidate-remi- fentanil and propofol-remifentanil sedation in patients scheduled for colonoscopy 显示文摘 | Toklu S Iyilikci L Gonen C | 2009 | Eur J Anaesthesiol2009，26，5： | 1 |
| 17 | Comparison of etomidate-remifentaniland propofol-remifentanil sedation ill patients scheduled forcolonoscopy显示文摘 | Toklu S lyilikci L Gonen C | 2009 | Eur J Anaesthesiol2009，26，5： | 1 |
| 18 | Patient doses and dosimetric evaluations in interventional cardiology显示文摘 | Bor D Ol~ar T Toklu T | 2009 | Phys Med2009，25，1： | 1 |
| 19 | Comparison of etomidate - remifentanil and propofol - remifentanil sedation in patients scheduled for colonoscopy 显示文摘 | Toklu S Iyilikci L Goncn C | 2009 | Eur J Anaesthesiol2009，26，5： | 1 |
| 20 | Effects of age, gender, and cognitive, functional and motor status on functional outcomes ofstroke rehabilitation显示文摘 | Ones K Yalcinkaya EY Toklu BC | 2009 | NeuroRehabilitation2009，25，： | 1 |
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