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| 1 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 2 | 关于指数丢番图方程a^x+(3a^2-1)~y=(4a^2-1)~z的正整数解(英文)显示文摘本文通过计算Jacobi符号,运用代数数的对数线性型的下界估计,证明了:当整数a>1时,指数丢番图方程a^x+(3a^2-1)~y=(4a^2-1)~z仅有正整数解(x,y,z)=(2,1,1). | 何波 Togbe Alain | 2011 | 数学进展2011，40，2： | 3 |
| 3 | Inflammasome-IL-1 -Th17 response in allergic lung inflammation 显示文摘 | Besnard AG Togbe D Couillin I | 2012 | J Mol Cell Biol2012，4，1： | 1 |
| 4 | Importance and Role of Biodiversity and Tropical Forests in the Cultural, Socio-Economic and Religious Life of African Black People: Case of Benin显示文摘 | Adjovi Edmond Codjo Amadji Togbe Armel Olodo Emmanuel | 2017 | Journal of Environmental Science and Engineering(B)2017，6，6： | 1 |
| 5 | Interleukin-17 is a negative regulator of established allergic asthma显示文摘 | Candrian SS Togbe D Couillin I | | 0，，12： | 1 |
| 6 | Tumor necrosis factor is critical to control tuberculosis infection显示文摘 | JACOBS M TOGBE D FREMOND C | 2007 | Microbes Infect2007，9，5： | 1 |
| 7 | Tumor necrosis factor is critical to control tuberculosis infection显示文摘 | Jacobs M Togbe D Fremond C | 2007 | Microbes and Infection2007，9，5： | 1 |
| 8 | Interleukin-17 is a negative regulator of established allergic asthma显示文摘 | Schnyder-Candrian S Togbe D Couillin I | | 0，，12： | 1 |
| 9 | Solving a family of theequations with an application to the equation x1 - Dy ~ 1显示文摘 | Togbe A Voutier P M Walsh P G | 2005 | Acta Arith2005，120，1： | 1 |
| 10 | Inflammasome-IL-1-Th17 response in allergic lung inflammation显示文摘 | Besnard A G Togbe D Couillin I Tan Z Zheng S G Erard F | 2012 | J Mol Cell Biol2012，4，： | 1 |
| 11 | Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury显示文摘 | Togbe D Schnyder-Candrian S Schnyder B | | 0，，06： | 1 |
| 12 | IL-33-activated den- dritic cells are critical for allergic airway inflammation显示文摘 | Besnard A G Togbe D Guillou N | 2011 | Eur J Immunol2011，41，6： | 1 |
| 13 | Interleukin-17 is a negative regulator of established allergic asthma 显示文摘 | Sehnydet Candrian S Togbe D Couillin | 2006 | J Exp Med2006，203，： | 1 |
| 14 | IL-33-activated dendritic cells are eritieal for allergic airway inflammation显示文摘 | Besnard AG Togbe D Guillou N | 2011 | EurJ Immunol2011，41，6： | 1 |
| 15 | Murine cerebral malaria development is independent of toll-like receptor signaling显示文摘 | Togbe D Schofield L Grau GE | 2007 | Am J Pathol2007，170，5： | 1 |
| 16 | Interleukin-17 is a negative regulator of established allergic asthma显示文摘 | Schnyder-Candrian S Togbe D Couillin I | 2006 | J Exp Med2006，203，12： | 1 |
| 17 | Oxidation kinetics of butanol- gasoline surrogate mixtures in a jet-stirred reactor ex- perimental and modeling study显示文摘 | Dagaut P Togbe C | 2008 | Fuel2008，87，1516： | 1 |
| 18 | Interleukin-17 is a negative regulator of established allergic asthma显示文摘 | Schnyder-Candrian S Togbe D Couillin I | 2006 | J Exp Med2006，203，12： | 1 |
| 19 | Auto- ignition and combustion characteristics in HCC1 and JSR using 1-butanol/n-heptane and ethanol/n-heptane blends显示文摘 | Saisirirat P Togbe C Chanchaona S | 2011 | Proceedings of the Combustion Institute2011，33，2： | 1 |
| 20 | TLR4 gene dosage contributes to endotoxin-induced acute resptratory inflammation 显示文摘 | Togbe D Sehnyder-Candrian S Schnvder B | 2006 | J Leukoc Biol2006，80，3： | 1 |
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