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| 1 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 2 | Functional properties of wheat glutenin显示文摘 | Weegels P L Hamer R J Schofield J D | 1996 | Ceral Sci1996，23，： | 2 |
| 3 | P recision L ivestock F arming: A n international review of scientific and commercial aspects显示文摘Precision Livestock Farming(PLF)is potentially one of the most powerful developments amongst a number of interesting new and upcoming technologies that have the potential to revolutionise the livestock farming industries.If properly implemented,PLF or Smart Farming could(1)improve or at least objectively document animal welfare on farms;(2)reduce greenhouse gas(GHG)emission and improve environmental performance of farms;(3)facilitate product segmentation and better marketing of livestock products;(4)reduce illegal trading of livestock products;and(5)improve the economic stability of rural areas.However,there are only a few examples of successful commercialisation of PLF technologies introduced by a small number of commercial companies which are actively involved in the PLF commercialisation process.To ensure that the potential of PLF is taken to the industry,it is recommended to:(1)establish a new service industry;(2)verify,demonstrate and publicise the benefits of PLF;(3)better coordinate the efforts of different industry and academic organisations interested in the development and implementation of PLF technologies on farms;and(4)encourage the commercial sectors to assist with professionally managed product development. | T M Banhazi H Lehr J L Black H Crabtree P Schofield M Tscharke D Berckmans | 2012 | International Journal of Agricultural and Biological Engineering2012，5，3： | 2 |
| 4 | Automated gel permeation chromatographic preparation of vegetables fruits and crops for organophosphorus pesticides determination utilizing flame photometric detection显示文摘 | Ault J A Schofield C M Johnson L D | 1979 | Journal of Agricultural and Food Chemistry1979，27，4： | 1 |
| 5 | Real-time monitoring of the development and stability of biofilms of Streptococcus mutans using the quartz crystal microbalance with dissipation monitoring 显示文摘 | Schofield A L | 2007 | Biosensors and Bioelectronics2007，23，： | 1 |
| 6 | Myocardial uptake of a (99m)Tc-nitroheterocycle in a swine model of occlusion and reperfusion 显示文摘 | Johnson LL Schofield L Donahay T | 2000 | J Nucl Med2000，41，： | 1 |
| 7 | Smooth muscle cell prolif- eration index correlates with 111 In-labeled antibody Z2 D3 uptake in a transplant vasculopathy swine model 显示文摘 | Jimenez J Donahay T Schofield L | 2005 | J Nucl Med2005，46，3： | 1 |
| 8 | Larginine transport and metabolism in Giardia intestinalis support its position as a transition between the prokaryot- ic and eukaryotic kingdoms 显示文摘 | KNODLER L A SCHOFIELD P J EDWARDS M R | 1995 | Microbiology1995，141，5： | 1 |
| 9 | CD4^+ CD25^+ regulatory T cells suppress CD4^+ T cell function and inhibit the development of Plasmodium berghei specific TH1 responses involved in cerebral malaria pathogenesis 显示文摘 | Nie CQ Bernard NJ Schofield L | 2007 | Infect Immun2007，75，5： | 1 |
| 10 | Functional properties of wheat glutenin显示文摘 | Weegels P L Hamer R J Schofield J D | 1996 | Journal of Cereal Science1996，23，： | 1 |
| 11 | Functional properties of wheat glutenin显示文摘 | WEEGELS P L HAMER R J SCHOFIELD J D | 1996 | Jurnal of Cereal Science1996，23，： | 1 |
| 12 | Aluminum toxicity to fish in acidic waters显示文摘 | Baker J P Schofield C L | 1982 | Water Air and Soil Pollution1982，18，28： | 1 |
| 13 | Functional proper ties of wheat glutenin显示文摘 | Weegels P L Hammer R J Schofield J D | 1996 | Journal of Cereal Science1996，23，： | 1 |
| 14 | Automated gel permeation chromatographic preparation of vegetables fruits and crops for organophosphorus pesticides determination utilizing flame photometric detection显示文摘 | AULT J A SCHOFIELD C M JOHNSON L D | 1979 | J Agric Food Chem1979，27，4： | 1 |
| 15 | Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test显示文摘 | Schofield L Watson N Grieu F | 2009 | Int J Cancer2009，124，5： | 1 |
| 16 | Silver and gold glyconano-particles for colorimetric bioassays显示文摘 | Schofield C L Haines A H Field R A Russell D A | 2006 | Langmuir2006，22，： | 1 |
| 17 | Automated gel permeation chromatographic preparation of vegetables, fruits,and crops for organophosphate residue determination utilizing flame photometric detection显示文摘 | Ault J A Schofield C M Johnson L D | 1979 | J Agric Food Chem1979，27，： | 1 |
| 18 | Discontinuous molecular dynamics for semiflexible and rigid bodies显示文摘 | de la Pena L H van Zon R Schofield J | 2007 | Journal of Chemical Physics2007，126，07： | 1 |
| 19 | Functional properties of wheat glutenin显示文摘 | Weegel S P L Hamer R J Schofield J D | 1996 | Journal of Cereal Science1996，23，： | 1 |
| 20 | An extrasynaptic GABAA receptor mediates tonic inhibition in thalamie VB neurons 显示文摘 | JIA F PIGNATARO L SCHOFIELD C M | 2005 | J Neurophysiol2005，94，6： | 1 |
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