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| 1 | Histamine 3 receptor activation mediates inhibition of acid secretion during Helicobacter-induced gastritis显示文摘AIM:To test the hypothesis that histamine 3 receptor (H3R)activation during Helicobacter infection inhibits gastric acid secretion in vivo and in vitro.METHODS:Helicobacter felis(H.felis)infected and uninfected C57Bl/6 mice were infused with either PBS or the H3 receptor antagonist thioperamide(THIO)for 12 wk.After treatment,mice were analyzed for morphological changes and gastric acid content.Total RNA was prepared from the stomachs of each group and analyzed for changes in somatostatin and gastrin mRNA abundance by real time-polymerase chain reaction(RTPCR).Location of H3 receptors in the stomach was analyzed by co-localization using antibodies specific for the H3 receptor and parietal cell marker H + ,K + -ATPase βsubunit. RESULTS:Inflammation and parietal cell atrophy was observed after 12 wk of H.felis infection.Interestingly, treatment with the H3R antagonist thioperamide(THIO) prior to and during infection prevented H.felis-induced inflammation and atrophy.Compared to the uninfected controls,infected mice also had significantly decreased gastric acid.After eradication of H.felis with THIO treatment,gastric acidity was restored.Compared to the control mice,somatostatin mRNA abundance was decreased while gastrin gene expression was elevated during infection.Despite elevated gastric acid levels, after eradication of H.felis with THIO,somatostatin mRNA was elevated whereas gastrin mRNA was suppressed.Immunofluorescence revealed the presence of H3 receptors on the parietal cells,somatostatin-secreting D-cells as well as the inflammatory cells. CONCLUSION:This study shows that during H.felis infection,gastric acidity is suppressed as a consequence of an inhibitory effect on the parietal cell by H3R activation.The stimulation of gastric mucosal H3Rs increases gastrin expression and release by inhibiting release of somatostatin. | Yana Zavros Nisreen Mesiwala Meghna Waghray Andrea Todisco Arthur Shulkes Juanita L Merchant | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 2 |
| 2 | The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner显示文摘 | Wang LD Wang M Todisco A | | 0，，06： | 1 |
| 3 | Clinical and bacteriological outcomes in hospitalised patients with community - acquired pneumonia treated with azithromycin plus ceftriaxone, or ceftriaxone plus clarithro- mycin or erythromycin: A prospective, randomised, multieentre study 显示文摘 | Tamm M Todisco T Feldman C | 2007 | Clin Microbiol Infect2007，13，2： | 1 |
| 4 | Interleukin-4 variant (BAY36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells显示文摘 | Srivannaboon K Shanafelt AB Todisco E | 2001 | Blood2001，97，： | 1 |
| 5 | Radioisotopic method for nasal mucociliary function evaluation显示文摘 | Paludetti G Todisco T Fedeli L | 1988 | Rhinology1988，26，： | 1 |
| 6 | Identification of the mitochondrial NAD + transporter in Saccharomyces cerevisiae 显示文摘 | Todisco S Agrimi G Castegna A | 2006 | J Biol Chem2006，281，3： | 1 |
| 7 | Comparing ther apeutic efficacy between ivermectin, selamectin, and moxideetin in canaries during natural infection withDermanyssus galli- nae显示文摘 | Todisco G Paoletti B Giammarino A | 2008 | AnnNYAcadSci2008，1149，： | 1 |
| 8 | Gastrin and glycine-extended progastrin processing intermedicates induce different programs of early gene activation 显示文摘 | Todisco A Takeuchi Y Seva C | 1995 | J Bilog Chem1995，270，28： | 1 |
| 9 | Molectdar mechanisms for the antiapoptotic action of gastrin显示文摘 | Todisco A Ramamoorthy S Witham T | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，： | 1 |
| 10 | Spatio-temporal variability of precipitation, temperature and agricultural drought indices in Central Italy显示文摘 | Vergni L Todisco F | 2011 | Agri-cultural and Forest Meteorology2011，151，3： | 1 |
| 11 | Molecular basis for somatostatin action:inhibiiition of c-fos expression and AP-1binding显示文摘 | Todisco A Campbell V Dickinson CJ | 1994 | Am J Physiol1994，267，21： | 1 |
| 12 | Molecular mechanism for somatostatin inhibition of c-fos gene expression显示文摘 | Todisco A Takeuchi Y Yamada J | 1997 | Am J Physiol1997，272，3： | 1 |
| 13 | Molecular basis for somatostatin action :inhibition of c-fos expression and AP-1 binding显示文摘 | Todisco A Campbell V Dickinson CJ | 1994 | Am J Physiol1994，267，5： | 1 |
| 14 | Intracellular mechanisms mediating the anti-apoptotic action of gastrin显示文摘 | Ramamoorthy S Stepan V Todisco A | 2004 | Biochem biophys Res Gommun2004，323，1： | 1 |
| 15 | Somatostatin inhibits AP-1 function via multiple protein phosphatases显示文摘 | Todisco A Seva C Takeuchi Y | 1995 | Am J Physiol1995，269，10： | 1 |
| 16 | Early loading of implants in vertically augmented bone with non-resorbable membranes and deproteinised anorganic bovine bone,An uncontrolled prospective cohort study 显示文摘 | Todisco M | 2010 | Eur J Oral Implantol2010，3，1： | 1 |
| 17 | High versus low implant insertion torque: a histologic, histomorphometric, and biomechanical study in the sheep mandible显示文摘 | Trisi P Todisco M Consolo U | 2011 | Int J Oral Maxillofac Implants2011，26，4： | 1 |
| 18 | Climatic changes in central Italy and their potential effects on corn water consumption显示文摘 | Todisco F Vergniagr L | 2008 | Agricultural and Forest Meteorology2008，148，： | 1 |
| 19 | CD38 ligation inhibits normal and leukemic myelopoiesis显示文摘 | Todisco E Suzuki T Srivannaboon K | 2000 | Blood2000，95，2： | 1 |
| 20 | CD38 in hematopoiesis显示文摘 | Campana D Suzuki T Todisco E | 2000 | Chem Immunol2000，75，9： | 1 |
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