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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | Enalapril prevents fatty liverin nephritic rats显示文摘 | Toblli JE Ferder L Stella I | 2002 | J Nephrol2002，15，4： | 1 |
| 3 | ACE inhibitor and angiotensin type I receptor antagonist in combination reduce renal damage in obese Zucker rats显示文摘 | Toblli JE DeRosa G Cao G | 2004 | Kidney Int2004，65，6： | 1 |
| 4 | The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency显示文摘 | Toblli JE Stella I Mazza ON | 2006 | Journal of Nephrology2006，19，4： | 1 |
| 5 | Enalaprilattenuates oxidative stress in diabetic rats显示文摘 | DE CAVANAGH EM INSERRA F TOBLLI J | 2001 | Hypertension2001，38，5： | 1 |
| 6 | ACE inhibitor and angiotensin type Ⅰ receptor antagonist in combination reduce renal damage in obese Zucker rats显示文摘 | Toblli JE DeRosa G Cao G | 2004 | Kidney Int2004，65，6： | 1 |
| 7 | Angiotensin-converting enzyme inhibition and angiogenesis in myocardium of obese Zucker rats 显示文摘 | Toblli JE Cao G DeRosa G | 2004 | Am J Hypertens2004，17，： | 1 |
| 8 | Intravenous iron reduces N'F-pro- brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency显示文摘 | Toblli JE Lombrana A Duarte P | 2007 | J Am Coil Cardio12007，50，17： | 1 |
| 9 | Potassium citrate administration ameliorates tubulointerstial lesions in rats with uric acid nephropathy显示文摘 | Toblli J E DeRose G Lago N | 2001 | Clin Nephrol2001，55，1： | 1 |
| 10 | Long-term treatment with nebivolol attenuates renal damage in Zucker diabetic fatty rats显示文摘 | Toblli JE Cao G Giani JF | 2011 | JHypertens2011，29，8： | 1 |
| 11 | Enalapril prevents fatty liver in nephrotic rats显示文摘 | TOBLLI J E FERDER L STELLA I | 2002 | J Nephrol2002，15，4： | 1 |
| 12 | Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan显示文摘 | TOBLLI J E CAO G LOMBRANA A | 2007 | J Sex Med2007，4，5： | 1 |
| 13 | ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats显示文摘 | Toblli J E Munoz M C Cao G | 2008 | Obesity (Silver Spring)2008，16，： | 1 |
| 14 | Antifibrotic effects of piogli-tazone at low doses on the diabetic rat kidney are asso-ciated with the improvement of markers of cell turn-over,tubular and endothelial integrity,and angiogenesis显示文摘 | Toblli J E Cao G Giani J F Angerosa M Dominici FP Gonzalez-Cadavid N F | 2011 | Kidney Blood Press Res2011，34，： | 1 |
| 15 | Morphological changes in cavernous tissue in spontaneously hypertensive rats显示文摘 | Toblli JE Stella I Inserra F | | 0，，6： | 1 |
| 16 | Anti-fibrotie effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitas显示文摘 | Toblli J E Ferrini M G Caa G | 2009 | Nephrol Dial transplant2009，24，8： | 1 |
| 17 | Antifibrotic effects ofpiogli-tazone on the kidney in a rat model of Type 2 diabetes meUitus 显示文摘 | Toblli JE Ferrini MG Cao G | 2009 | Nephrol Dial Transplant2009，24，8： | 1 |
| 18 | Morphological changes in cavernous tissue in spontaneously hypertensive rats显示文摘 | Stella I Inserra F | 2000 | Am J Hypertens2000，13，61： | 1 |
| 19 | ACE inhibitor and angiotensin typeⅠreceptor antagonist in combination reduce renal damage in obese Zueker rats显示文摘 | Toblli JE DeRosa G Cao G | 2004 | Kidney Int2004，65，6： | 1 |
| 20 | Potassium citrate administration ameliorates tubulointerstial lesions in rats with uric acid nephropathy 显示文摘 | TOBLLI J E DE ROS G LAGO N | 2001 | Clin Nephrol2001，55，1： | 1 |
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