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| 1 | Immunotherapy in colorectal cancer: Available clinical evidence,challenges and novel approaches显示文摘In contrast to other tumor types, immunotherapy has not yet become a relevant part of the treatment landscape of unselected colorectal cancer. Beside the small subgroup of deficient mismatch repair or microsatellite instable tumors (about 5%) as a surrogate for high mutational burden and subsequently high neoantigen load and immunogenicity, inhibitors of programmed death 1 (PD-1), programmed death ligand 1 (PD-L1) and/or cytotoxic T lymphocyte-associated antigen-4 were not or only modestly effective in metastatic colorectal cancer. Thus, a variety of combination approaches with chemotherapy, targeted therapy, toll-like receptor agonists, local ablation or oncolytic viruses is currently being evaluated in different disease settings. Despite several encouraging single arm data already presented or published, available randomized data are unimpressive. Adding PD-1/PD-L1 inhibitors to fluoropyrimidines and bevacizumab maintenance showed no beneficial impact on delaying progression. In refractory disease, the combination of PD-1/PD-L1 and MEK inhibitor was not different from regorafenib, whereas a PD-1/PD-L1 and cytotoxic T lymphocyteassociated antigen-4 inhibitor combination demonstrated better overall survival compared to supportive care alone. Clinical trials in all disease settings applying different combination approaches are ongoing and may define the role of immunotherapy in colorectal cancer. | Joseph Tintelnot Alexander Stein | 2019 | World Journal of Gastroenterology2019，25，29： | 5 |
| 2 | Eeidemiological data of cryp- tococcosis in Austria, Gemmany and Switzerland:part of the ECMM survey in Europe 显示文摘 | Tintelnot K Seht G Polak A | 2001 | Mycises2001，44，9： | 1 |
| 3 | Susceptibility testing of fungi - current status and open questions 显示文摘 | Seibold M Tintelnot K | 2003 | Prog Drug Res2003，，9： | 1 |
| 4 | Successful treatment of ocular invasive mould infection(fusariosis) with the new antifungal agent voriconazole显示文摘 | Reis A Sundmacher R Tintelnot K | 2000 | Br J Ophthalmol2000，84，8： | 1 |
| 5 | Successful treatment of ocular invasive mould infection (fusariosis) with the new antifungal agent voriconazole显示文摘 | Sundmacher R Tintelnot K | 2000 | Br J Ophthalmol2000，84，： | 1 |
| 6 | Rapid PCR-based diagnosis of disseminated histoplasmosis in an AIDS patient显示文摘 | Rickerts V Bialek R Tintelnot K | 2002 | Eur J Clin Microbiol Infect Dis2002，21，11： | 1 |
| 7 | Endosperm-limited Brassicaceae seed germination:Abscisic Acid Inhibits embryo- induced endosperm weakening of Lepidium sativum (cress) and endosperm rupture of Cress and Arabidopsis thaliana显示文摘 | Mfiller K Tintelnot S Leubner-Metzger G | 2006 | Plant Cell Physiol2006，47，： | 1 |
| 8 | Epidemiological data of Cryptococcosisin Austria, Germany and Switzerland: part of the ECMM survey in Europe显示文摘 | Tintelnot K Schar G Polak A | 2001 | Mycoses2001，44，910： | 1 |
| 9 | Sea-ice transport of riverine particles from the Laptev Sea to Fram Strait based on clay mineral studies 显示文摘 | Dethleff D Rachold V Tintelnot M | 2000 | International Journal of Earth Sciences2000，89，： | 1 |
| 10 | Successful treatment of ocular invasive mould infection (fusariosis) with the new antifungal agent voriconazole 显示文摘 | Reis A Sundmacher R Tintelnot K | 2000 | Br J Opthalmol2000，84，8： | 1 |
| 11 | Taenia-crassiceps-Infektion bei AIDS显示文摘 | H. Klinker K. Tintelnot R. Joeres J. Müller U. Gro? H. Schmidt-Rotte P. Landwehr E. Richter | 1992 | Dtsch med Wochenschr1992，，04： | 1 |
| 12 | Susceptibility testing of fungi-current status and open questions显示文摘 | Seibold M Tintelnot K | 2003 | Prog Drug Res2003，9，： | 1 |
| 13 | Epidemiological data of cryptococcosis in Austria,Germany and Switzerland:part of the ECMM survey in Europe显示文摘 | Tintelnot K Schar G Polak A | 2001 | Mycoses2001，44，： | 1 |
| 14 | Rapid PCR-based diagnosis of disseminated histoplasmosis in an AIDS patient显示文摘 | Rickerts V Bialek R Tintelnot K | 2002 | Eur J Clin Micro- biol Infect Dis2002，21，11： | 1 |
| 15 | Exporting and the environment: A new look with micro - data 显示文摘 | GIRMA TINTELNOT | 2008 | Kiel Working Papers2008，，： | 1 |
| 16 | Susceptibility testing of fungi-current status and open questions显示文摘 | Seibold M Tintelnot K | 2003 | Prog Drug Res2003，9，： | 1 |
| 17 | Susceptibility testing of fungi-current status and open questions显示文摘 | SEIBOLD M TINTELNOT K | 2003 | Prog Drug Res2003，9，： | 1 |
| 18 | Eeidemiological data of eryptococeosis in Austria,Gemmany and Switzerland:part of the ECMM survey in Europe显示文摘 | Tintelnot K Seht 13 Polak A | 2001 | Mycises2001，44，9： | 1 |
| 19 | Proposed nomenclature for Pseudallescheria,Scedosporium and related genera显示文摘As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied taxa.The generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic conidia.Considering that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are proposed.Pseudallescheria minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and S.desertorum,respectively.Scedosporium prolificans is renamed as Lomentospora prolificans. | Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gené Fabiola Fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes | 2014 | Fungal Diversity2014，，4： | 1 |
| 20 | Cytotoxicity of triterpenoid saponins Part 2 : Relationships between the structures of glycosides of polygalacic acid and their activities against pathogenic candina species显示文摘 | Bader G Seibold M Tintelnot K | 2000 | Pharmazie2000，55，1： | 1 |
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