1篇
您的检索式：作者名="Tingjun Ye"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Strontium doped electrospinning fiber membrane with antibacterial and osteogenic properties prepared by pulse electrochemical method显示文摘The osteogenic differentiation and new bone formation are commonly delayed by bacterial infection of orthopedic implants,which is urgent to be resolved quickly in the clinic.The current paper prepared a strontium-doped elec-trospinning fiber membrane with antibacterial and osteogenic properties by pulse electrochemical method.Poly-lactic acid/hydroxyapatite(PLLA/HA)composite fiber substrate was fabricated by electrospinning technology,and strontium doped SrHA/Cu/Polypyrrole(PPy)composite coating was constructed with pulse electrodeposi-tion method on its surface.The strontium doping technique,degradation of Sr^(2+)and Cu^(2+),cellular compatibility,and the antibacterial activity of the fiber membrane were examined.The results revealed that the deposition of phosphorus and calcium on composite fiber was the highest,indicating good biological activity.The release of Sr^(2+)and Cu^(2+)was stable and gradual due to the modulation of PPy.The composite fiber presented excellent antibacterial performance and the antibacterial rate was close to 100%against Staphylococcus aureus and Es-cherichia coli.Furthermore,it is conducive to the adhesion,spread,and proliferation of vascular endothelial cells and osteoblasts,namely outstanding osteogenesis and angiogenesis abilities.In conclusion,the multifunctional PLLA/HA@SrHA/Cu/PPy composite fiber membrane with good antibacterial and osteogenic activity by electro-spinning technology and pulsed electrochemical deposition method provides an effective strategy for the poor bone healing of infected bone defects. | Yonggang Liu Bolin Zhang Feifei Liu Yani Qiu Wenbo Mu Liang Chen Chuang Ma Tingjun Ye Yingbo Wang | 2022 | Engineered Regeneration2022，3，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员