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| 1 | Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘 | Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding | 2014 | Cell Research2014，24，1： | 6 |
| 2 | Predictors and long-term prognosis of early and late recurrence for patients undergoing hepatic resection of hepatocellular carcinoma: a large-scale multicenter study显示文摘Recurrence is common among patients undergoing hepatic resection for hepatocellular carcinoma(HCC),which greatly limits long-term survival.We aimed to identify predictors and long-term prognosis of early and late recurrence after HCC resection.Methods:Multicenter data of patients who underwent HCC resection between 2002 and 2016 were analyzed.Recurrence was divided into early(≤2 years)and late recurrence(>2 years after surgery).Predictors of early and late recurrence,and prognostic factors of post-recurrence survival(PRS)were identified by univariate and multivariate analyses.Results:Among 1,426 patients,554(38.8%)and 348(24.4%)developed early and late recurrence,respectively.Independent predictors associated with early recurrence included preoperative alpha-fetoprotein level>400μg/L,resection margin<1 cm,and tumor size>5.0 cm,multiplicity,macrovascular and microvascular invasion,and satellites of the initial tumor at the first diagnosis of HCC;independent predictors associated with late recurrence included male,cirrhosis,and tumor size>5.0 cm,multiplicity,macrovascular and microvascular invasion,and satellites of the initial tumor.Patients with early recurrence had a lower likelihood of undergoing potentially curative treatments for recurrence(37.2%vs.48.0%,P<0.001)and a worse median PRS(13.5 vs.36.6 months,P<0.001)vs.patients who had late recurrence.Multivariate analysis revealed that early recurrence and irregular postoperative surveillance were independently associated with worse PRS[hazard ratio(HR)=1.250,95%CI:1.016-1.538,P=0.035;and HR=1.983,95%CI:1.677-2.345,P<0.001].Conclusions:Predictors associated with early and late recurrence after curative resection for patients with HCC were generally same,although several did differ.Patients with late recurrence had better long-term survival than patients with early recurrence. | Wen-Tao Yan Chao Li Lan-Qing Yao Hai-Bo Qiu Ming-Da Wang Xin-Fei Xu Ya-Hao Zhou Hong Wang Ting-Hao Chen Wei-Min Gu Jian-Hong Zhong Han Wu Timothy M.Pawlik Wan Yee Lau Feng Shen Tian Yang | 2023 | Hepatobiliary Surgery and Nutrition2023，12，2： | 2 |
| 3 | Spatial targeting evaluation of energy and environmental performance of waste-to-energy processing显示文摘Waste-to-energy supply chains are important potential contributors to minimising the environmental impacts of municipal solid waste by reducing the amounts of waste sent to landfill,as well as the fossil fuel consumption and environmental footprints.Accounting for the spatial and transport properties of the waste-to-energy supply chains is crucial for understanding the problem and improving the supply chain designs.The most significant challenge is the distributed nature of the waste generation and the household energy demands.The current work proposes concepts and a procedure for targeting the size of the municipal solid waste collection zone as the first step in the waste-to-energy supply chains synthesis.The formulated concepts and the provided case study reveal trends of reducing the net greenhouse gas savings and energy recovery by increasing the collection zone size. Population density has a positive correlation with the greenhouse gas saving and energy recovery performance. For smaller zone size the energy recovery from waste approaches and in some cases may surpass the energy spent on waste transportation.The energy recovery and greenhouse gas savings remain significant even for collection zones as large as 200km^2.The obtained trends are discussed and key directions for future work are proposed. | Petar S.Varbanov Timothy G.Walmsley Yee V.Fan Jiri J.Klemes Simon J.Perry | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 1 |
| 4 | Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks显示文摘Background:Preoperative prediction of microvascular invasion(MVI)in hepatocellular carcinoma(HCC)may optimize individualized treatment decision-making.This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection(LR)and liver transplantation(LT)based on predicted MVI risks.Methods:We analysed 905 patients who underwent LR,including 524 who underwent anatomical resection(AR)and 117 who underwent LT for HCC within the Milan criteria using propensity score matching.A nomogram model was used to predict preoperative MVI risk.Results:The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT,respectively.Based on an optimal cut-off value of 200 points,the nomogram defined patients as high-or low-risk MVI groups.LT resulted in a lower 5-year recurrence rate and higher 5-year overall survival(OS)rate than LR among the high-risk patients(23.6%vs 73.2%,P<0.001;87.8%vs 48.1%,P<0.001)and low-risk patients(19.0%vs 45.7%,P<0.001;86.5%vs 70.0%,P=0.002).The hazard ratios(HRs)of LT vs LR for recurrence and OS were 0.18(95%confidence interval[CI],0.09–0.37)and 0.12(95%CI,0.04–0.37)among the high-risk patients and 0.37(95%CI,0.21–0.66)and 0.36(95%CI,0.17–0.78)among the low-risk patients.LT also provided a lower 5-year recurrence rate and higher 5-year OS rate than AR among the high-risk patients(24.8%vs 63.5%,P=0.001;86.7%vs 65.7%,P=0.004),with HRs of LT vs AR for recurrence and OS being 0.24(95%CI,0.11–0.53)and 0.17(95%CI,0.06–0.52),respectively.The 5-year recurrence and OS rates between patients undergoing LT and AR were not significantly different in the low-risk patients(19.4%vs 28.3%,P=0.129;85.7%vs 77.8%,P=0.161).Conclusions:LT was superior to LR for patients with HCC within the Milan criteria with a predicted high or low risk of MVI.No significant differences in prognosis were found between LT and AR in patients with a low risk of MVI. | Pinghua Yang Fei Teng Shilei Bai Yong Xia Zhihao Xie Zhangjun Cheng Jun Li Zhengqing Lei Kui Wang Baohua Zhang Tian Yang Xuying Wan Hao Yin Hao Shen Timothy M Pawlik Wan Yee Lau Zhiren Fu Feng Shen | 2023 | Gastroenterology Report2023，11，1： | 1 |
| 5 | Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes显示文摘Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of insulin signaling in the growth plate. Insulin treatment of embryonic metatarsal bones from wild-type mice increased chondrocyte proliferation. Mice lacking insulin receptor(IR) selectively in chondrocytes(CartIR2/2)had no discernable differences in total femoral length compared to control littermates. However, CartIR2/2mice exhibited an increase in chondrocyte numbers in the growth plate than that of the controls. Chondrocytes lacking IR had elevated insulin-like growth factor(IGF)-1R mRNA and protein levels. Subsequently, IGF-1induced phosphorylation of Akt and ERK was enhanced, while this action was eliminated when the cells were treated with IGF-1R inhibitor Picropodophyllin. Deletion of the IR impaired chondrogenic differentiation, and the effect could not be restored by treatment of insulin, but partially rescued by IGF-1 treatment. Intriguingly,the size of hypertrophic chondrocytes was smaller in CartIR2/2mice when compared with that of the control littermates, which was associated with upregulation of tuberous sclerosis complex 2(TSC2). These results suggest that deletion of the IR in chondrocytes sensitizes IGF-1R signaling and action, IR and IGF-1R coordinate to regulate the proliferation, differentiation and hypertrophy of growth plate chondrocytes. | Fengjie Zhang Qiling He Wing Pui Tsang W Timothy Garvey Wai Yee Chan Chao Wan | 2014 | Bone Research2014，2，2： | 1 |
| 6 | Association of tumor morphology with long-term prognosis after liver resection for patients with a solitary huge hepatocellular carcinoma-a multicenter propensity score matching analysis显示文摘Background:A solitary hepatocellular carcinoma(HCC)without macrovascular invasion and distant metastasis,regardless of tumor size,is currently classified as early-stage disease by the latest Barcelona Clinic Liver Cancer(BCLC)staging system.While the preferred treatment is surgical resection,the association of tumor morphology with long-term survival outcomes after liver resection for a solitary huge HCC of≥10 cm has not been defined.Methods:Patients who underwent curative liver resection for a solitary huge HCC were identified from a multicenter database.Preoperative imaging findings were used to define spherical-or ellipsoidal-shaped lesions with smooth edges as balloon-shaped HCCs(BS-HCCs);out-of-shape lesions or lesions of any shape with matt edges were defined as non-balloon-shaped HCCs(NBS-HCCs).The two groups of patients with BS-HCCs and NBS-HCCs were matched in a 1:1 ratio using propensity score matching(PSM).Clinicopathologic characteristics,long-term overall survival(OS)and recurrence-free survival(RFS)were assessed.Results:Among patients with a solitary huge HCC,74 pairs of patients with BS-HCC and NBS-HCC were matched.Tumor pathological features including proportions of microvascular invasion,satellite nodules,and incomplete tumor encapsulation in the BS-HCC group were lower than the NBS-HCC group.At a median follow-up of 50.7 months,median OS and RFS of all patients with a solitary huge HCC after PSM were 27.8 and 10.1 months,respectively.The BS-HCC group had better median OS and RFS than the NBS-HCC group(31.9 vs.21.0 months,P=0.01;and 19.7 vs.6.4 months,P=0.015).Multivariate analyses identified BS-HCC as independently associated with better OS(HR=0.592,P=0.009)and RFS(HR=0.633,P=0.013).Conclusions:For a solitary huge HCC,preoperative imaging on tumor morphology was associated with prognosis following resection.In particular,patients with BS-HCCs had better long-term survival following liver resection versus patients with large NBS-HCCs. | Xin-Fei Xu Han Wu Ju-Dong Li Lan-Qing Yao Bin Huang Yong-Kang Diao Ting-Hao Chen Wei-Min Gu Zhong Chen Jie Li Yao-Ming Zhang Hong Wang Ying-Jian Liang Ya-Hao Zhou Chao Li Ming-Da Wang Cheng-Wu Zhang Timothy MPawlik Wan Yee Lau Feng Shen Tian Yang | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 0 |
| 7 | Stepping through a new door in La Porte IN显示文摘 In this issue of the Journal of Geriatric Cardiology,Yang et al.1 studied the effects of arotinolol, a beta-blocker (BB), on the right ventricular (RV) function.…… | Lan T. Nguyen Timothy Yee Thach Nguyen | 2007 | Journal of Geriatric Cardiology2007，4，3： | 0 |
| 8 | Understanding and clinical application of acute dilation of the left ventricle on ventricular arrhythmias显示文摘 In this issue of the Journal of Geriatric Cardiology,Yin et al discussed the effects of calcium preconditioning (CPC) and streptomycin (S) on acute dilation of the left ventricle.…… | Timothy Yee Thach Nguyen | 2007 | Journal of Geriatric Cardiology2007，4，3： | 0 |
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