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| 1 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia显示文摘 | Stephen AB Timothy WO Michael DB | 2002 | N Engl J Med2002，346，8： | 1 |
| 2 | Estrogen sulfation genes,hormone replacement therapy,and endometrial cancer risk显示文摘 | Timothy R Rebbeck TR Troxel AB | 2006 | J Natl Cancer Inst2006，98，18： | 1 |
| 3 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia 显示文摘 | Stephen AB Timothy WG Michael DB | 2002 | N Engl J ned2002，346，8： | 1 |
| 4 | Indimethacin compared with localized irradiation for the prevention o heterotopic ossification following surgical treatment of acetabular fractures 显示文摘 | Timothy AB Kent JL Jeffrey OA | 2001 | J Bone and Joint Surg2001，83，： | 1 |
| 5 | Cloning of a novel receptor subunit,AcPL,required for interleukin-18 signaling显示文摘 | Teresa LB Elisabeth T Timothy AB | 1998 | J Biol Chem1998，273，29： | 1 |
| 6 | Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models 显示文摘 | Timothy RQ Kelly AB Miles PH | 1998 | Free Radic Biol Med1998，24，5： | 1 |
| 7 | Delayed hemothorax after blunt thoracic trauma:an uncommon entity with significant morbidity 显示文摘 | Bruce JS Quyen C Timothy AB | 1998 | J Trauma1998，45，： | 1 |
| 8 | Delayed hemothorax after blunt thoracic trauma:an uncommon entity with significant morbidity显示文摘 | Bruce JS Quyen C Timothy AB | 1998 | Trauma1998，45，： | 1 |
| 9 | Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry显示文摘Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit quality.Blueberry cultivars have highly variable resistance against AFR.To date,this pathogen is largely controlled by applying various fungicides;thus,a more cost-effective and environmentally conscious solution for AFR is needed.Here we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry(Vaccinium corymbosum).Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids(e.g.anthocyanins)and resistance against pathogens.Furthermore,we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar,which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways(e.g.flavonol biosynthesis)and pathogen resistance.Using non-targeted metabolite profiling,we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping population.Further analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two groups.However,individuals within each group displayed considerable overlapping variation in this compound,suggesting that its abundance may only be partially associated with resistance against C.fioriniae.These findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies. | MacKenzie Jacobs Samantha Thompson Adrian E.Platts Melanie J.A.Body Alexys Kelsey Amanda Saad Patrick Abeli Scott J.Teresi Anthony Schilmiller Randolph Beaudry Mitchell J.Feldmann Steven J.Knapp Guo-qing Song Timothy Miles Patrick P.Edger | 2023 | Horticulture Research2023，10，10： | 0 |
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