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| 1 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | 白细胞介素-10在T_H1和T_H2反应相互调节中的作用显示文摘对于T 辅助细胞(T_H)亚群的识别进一步加深了对免疫效应功能调节的了解。T_H 亚群除控制体液免疫和延迟型超敏反应以外,还通过分泌抑制性细胞因子来相互调节。Tim Mosmann 和Kevin Moore 分析总结了这些现象,尤其是由T_H 2细胞分泌的能够抑制T_H 1细胞功能的白细胞介素-10的作用。 | Tim R Mosmann Kevin W Moore 边立军 | 1992 | 国外医学(免疫学分册)1992，15，1： | 5 |
| 4 | Optimal Contraction Intensity During Proprioceptive Neuromuscular Facilitation for Maximal Increase of Range of Motion显示文摘 | Peter W Sheard Tim J Paine | 2010 | Journal of Strength and Conditioning Research2010，，2： | 2 |
| 5 | 中国《网络安全法》的立法特色与国际影响显示文摘在中国的网络世界里,中国《网络安全法》立法,纵横捭阖、以启山林,原创性地开辟了中国特色的网络安全秩序。自该法2017年6月1日起实施一年来,各地的网信部门不断加强宣传和贯彻,但也反馈出了一些"网络执法权"不直接、不足够的问题,这是由于该法的立法定位着重于"统筹协调",不像《国家安全法》那样规定的是"统筹领导". | 赵宏瑞 张春雷 汤雯雯 TIM W?FFEN | 2018 | 中国信息安全2018，，7： | 2 |
| 6 | Grading system modification and management of blunt aortic injury显示文摘 | Kaavya N Reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang | 2013 | Chinese Medical Journal2013，，3： | 2 |
| 7 | Solids,organic load and nutrient concentration reductions in swine waste slurry using a polyacrylamide (PAM)-aided solids flocculation treatment显示文摘 | Paul W Tim K | | 0，，02： | 1 |
| 8 | Impact of oil type on nanoemulsion formation and ostwald ripening stability 显示文摘 | TIM J W MATF G PEERASAK S | 2008 | Langmuir2008，24，12： | 1 |
| 9 | Brain natriuretic peptide and acute hypobaric in humans显示文摘 | David W Tim H Adrian M | 2011 | Physiol Sci2011，61，： | 1 |
| 10 | Treatment of urinary incontinence by implantable prosthetic sphincter显示文摘 | Scott FB B radley W E Tim GW | 1973 | U rology1973，1，3： | 1 |
| 11 | The effect of bone morphogenetic protein-2 on rat in- tervertebral disc cells in vitro显示文摘 | Tim Yoon S Su Kim K Li J Soo Park J Akamaru T Elmer W A | 2003 | Spine(Phila Pa 1976)2003，28，： | 1 |
| 12 | 大鼠牙胚发育过程中釉原蛋白含量在空间和时间上的变化显示文摘目的 :研究随着大鼠牙胚的发育 ,釉原蛋白 (Am)在空间和时间上的变化。方法 :以重组、纯化的大鼠釉原蛋白为抗原。混入完全 /不完全弗氏佐剂 ,免疫新西兰大白兔 ;用双向免疫扩散法测抗体效价 ,将获得的多克隆抗血清经硫酸胺初步纯化后 ,用Westernblot和免疫组化检测大鼠牙胚Am的组织表达特异性。结果 :Westernblot显示 :在大鼠牙胚组织总蛋白中有特异性表达 ,而在肝、脑、肾组织中没有表达。免疫组化检测 ,在成釉细胞和发育早期的釉基质中有Am的表达 ,而在成牙本质细胞和成熟牙釉质、牙本质中无表达。结论 :釉原蛋白的表达具有严格的空间和时间依赖性 ,在牙胚发育早期高表达而在发育后期和已矿化期表达低或无表达。 | 隋文 洪咏龙 肖明振 Tim W | 2003 | 中国现代医学杂志2003，13，7： | 1 |
| 13 | A transaction-based approach to vertical partitioning for relational database systems显示文摘 | CHU W Wesley IEONG Ion Tim | 1993 | IEEE Transactions on Software Engineering1993，19，8： | 1 |
| 14 | Implementation of a MIMO OFDM-based Wireless LAN System显示文摘 | Allert van Zelst Tim C W | 2004 | IEEE Transactions on Signal Processing2004，52，02： | 1 |
| 15 | Stable carbon (12/13 C) and nitrogen (14/15N) isotopes as a tool for ide~ntifying the sources of cyanide in wastes and contaminated soils-A methoddevelopment 显示文摘 | JENNY W TIM M ULRIKE S | 2007 | Analytica Chimica Acta2007，582，： | 1 |
| 16 | Potential for the use of GIS and spatial analysis techniques as tools for monitoring changes in forest productivity and nutrition-a New Zealand example显示文摘 | Tim W Payna Reece B Hillb Barbara K Hoècka | 1999 | Forest Ecology and Management1999，122，： | 1 |
| 17 | Prevalence of maternal smoking and environmental tobacco smoke exposure during pregnancy and impact on birth weight : retrospective study using Millennium Cohort 显示文摘 | Corinne W Sarah L Tim C | 2007 | BMC Public Health2007，7，： | 1 |
| 18 | The mechanisms that associate community social cap- ital with post-disaster mental health: a multilevel model 显示文摘 | Tim R W Ivan H K | 2012 | Social science & medicine2012，，75： | 1 |
| 19 | Dead-zone compensation in motion control systems using adaptive fuzzy logic control 显示文摘 | LEWIS F L TIM W K WANG L Z | 1999 | IEEE Transactions on Control System Technology1999，7，6： | 1 |
| 20 | Pipeline integrity management显示文摘 | TIM W JOE D | 2012 | Society of Petroleum Engineers2012，26，： | 1 |
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