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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Small ruminant lentivirus Tat protein induces apoptosis in caprine cells in vitro by the intrinsic pathway显示文摘 | Angela R Stphanie V Tim G | 2009 | Virology2009，383，： | 1 |
| 3 | A review of pressure-driven membrane processes in wastewater treatment and drinking water production 显示文摘 | Bart V D B Carlo V Tim V G | 2003 | Environmental Progress2003，22，1： | 1 |
| 4 | The role of networks in small and medium-sized enterprise innovation and firm performance 显示文摘 | Sarel G Martie-louise V Tim K | 2012 | Journal of Small Business Management2012，50，2： | 1 |
| 5 | UnidirectionalEmission of a quantum dot coupled to a nanoantenna显示文摘 | Alberto G C Giorgio V Tim H T | 2010 | Science2010，329，： | 1 |
| 6 | Corrosion properties of alumina and titania NF membranes 显示文摘 | Tim V G Carlo V Anita B | 2003 | Journal of Membrane Science2003，214，1： | 1 |
| 7 | Alumina and Titania multilayer membranes for nanofiltration: preparation, characterization and chemical stability 显示文摘 | TIM V G CARLO V ANITA B | 2002 | Journal of Membrane Science2002，207，： | 1 |
| 8 | Corrosion properties of alumina and titania NF membranes 显示文摘 | TIM V G CARLO V ANITA B | 2003 | Journal of Membrane Science2003，214，： | 1 |
| 9 | Aerobic nonylphenol degradation and nitro-nonylphenol formation by microbial cultures from sediments 显示文摘 | JASPERIEN D W MARC V TIM G | 2010 | Appl Microbiol Biotechnol2010，86，： | 1 |
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