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| 1 | Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on human society.Several candidate vaccines against SARS-CoV-2 are now undergoing clinical trials.The Spike(S)protein of SARS-CoV-2 is widely considered as a promising antigen.However. | Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，8： | 5 |
| 2 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 3 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 4 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 5 | Congestion is an important diagnostic and therapeutic target in heart failure显示文摘 | Gheorghiade M Shin DD Thomas TO | 2006 | Rev Cardiovasc Med2006，7，1： | 1 |
| 6 | Insights into G protein structure function, and regulation 显示文摘 | Cabrera-Vera TM Vanhauwe J Thomas TO | 2003 | Endocr Rev2003，24，6： | 1 |
| 7 | Insights into G protein structure, function, and regulation 显示文摘 | Cabrera-Vera TM Vanhauwe J Thomas TO | 2003 | Endoer Rev2003，24，6： | 1 |
| 8 | Regional systems of innovation and the knowledge production function: the Spanish case 显示文摘 | Mikel Buesa Joostheijs Monica Martnez Pell Ite- to Thomas Baunert | 2006 | Technovati on2006，，26： | 1 |
| 9 | Kuli显示文摘 | | 1999 | MINING ENGINEERING1999，，9： | 1 |
| 10 | Insights into G protein structure,function,and regulation显示文摘 | Cabrera-Vera TM Vanhauwe J Thomas TO | 2003 | Endocr Rev2003，24，6： | 1 |
| 11 | Insights into G protein structure, function, and regulation 显示文摘 | Cabrera-Vera TM Vanhauwe J Thomas TO | 2003 | Endocr Rev2003，24，： | 1 |
| 12 | Bortezomib inhibits cell-cell adhesion and cell migration and enhances epidermal growth factor receptor inhibitor-induced cell death in squamous cell cancer 显示文摘 | Lorch JH Thomas TO Schmoll HJ | 2007 | Cancer Res2007，67，： | 1 |
| 13 | Correlation of heart rate and cardiac dysfunction in Duchenne muscular dystrophy 显示文摘 | Thomas TO Morgan TM Burnette WB | 2012 | Pediatr Cardiol2012，33，： | 1 |
| 14 | External Focus Instructions ReducePostural Instability in Individuals With Parkinson Disease显示文摘 | Gabriele Wulf Merrill Landers Rebecca Lewthwaite Thomas To¨llner | 2009 | Physical Therapy2009，2，： | 1 |
| 15 | The use of single‐agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child‐Pugh B liver cirrhosis显示文摘 | Joanne Chiu Yuen Fong Tang Tzy‐Jyun Yao Ashley Wong Hilda Wong Roland Leung Pierre Chan Tan To Cheung Albert C. Chan Roberta Pang Sheung‐Tat Fan Ronnie Poon Thomas Yau | 2012 | Cancer2012，，21： | 1 |
| 16 | Insights into G-protein structure,function,and regulation显示文摘 | Cabrera-Vera TM Vanhauwe J Thomas TO | 2003 | Endocr Rev2003，24，： | 1 |
| 17 | Brachial plexus dose tolerance in head and neck cancer patients treated with 9equential intensity modulated radiation therapy显示文摘 | Thomas TO P~efaat T Choi M et aI | 2015 | Radiation oneology (London England)2015，10，1： | 1 |
| 18 | Congestion is an important diagnostic and therapeutic target in heart failure 显示文摘 | Gheorghiade M Shin DD Thomas TO | 2006 | Rev Cardiovasc Med2006，71，： | 1 |
| 19 | Congestion is an important diagnostic and therapeutic target in heart failure显示文摘 | Gheorghiade M Shin DD Thomas TO | 2006 | Rev Cardiovasc Med2006，7，1： | 1 |
| 20 | Congestion is an important diagnostic and therapeutic target in heart failure 显示文摘 | Gheorghiade M Shin DD Thomas TO | 2006 | Rev Cardiovasc Med2006，71，： | 1 |
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