|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Effect of salinomycin and enzyme supplementation on nutrient digestibility and performance of pigs fed barley or rye based diets显示文摘 | Thacker P A Campbell G L | | 0，，： | 1 |
| 3 | The effect of organic acids and enzyme supplementation on the performance of pigs fed barley-based diets 显示文摘 | Thacker P A G L Campbell J W D GrootWassink | 1992 | Can J Anim Sci1992，72，： | 1 |
| 4 | Experimental infection of pregnant gilts with swine hepatitis E virus 显示文摘 | Kasomdorkbua C Thacker B J Halbur P G Guenette D K Buitenwerf R M Royer R L Meng X J | 2003 | Can J Vet Res2003，67，： | 1 |
| 5 | Effects of feeding low phytate barley on phosphorus forms in swine manure 显示文摘 | Leytem A B Turner B L Thacker P A | 2004 | J Environ Qual2004，33，： | 1 |
| 6 | Effect of porcine reproductive and respiratory syndrome virus(PRRSV) (isolate ATCC VR-2385) infection on bactericidal activity of porcine pulmonary intravascular macrophages (PIMs):in vitro comparisons with pulmonary alveolar macrophages (PAMs)显示文摘 | Thanawongnuwech R Thacker E L Halbur P G | | 0，，： | 1 |
| 7 | MiR-29b downregulates canonical Wnt signaling by suppressing coactivators of 显示文摘 | Subramanian M Rao SR Thacker P | 2014 | J Cell Biochem2014，115，11： | 1 |
| 8 | Non-parametric image subtraction using gray level scattergrams显示文摘 | Bromiley P A Thacker N A Courtney P | 2002 | Image and Vision Computing2002，120，： | 1 |
| 9 | Nutritional value of diets containing graded levels of wheat distillers grains with solubles fed to broiler chicks显示文摘 | THACKER P A WIDYARATNE G P | 2007 | Journal of the Science of Food and Agriculture2007，87，7： | 1 |
| 10 | Effects of stachyose on per- formance, diarrhoea incidence and intestinal bacteria in wean- ling pigs显示文摘 | Liying Zhang Li B Thacker P | 2003 | Archives of Animal Nutrition2003，57，1： | 1 |
| 11 | Set a microbe to kill a microbe: drug resistance renews interest in phage therapy显示文摘 | Thacker P D | 2003 | J Am Med2003，290，24： | 1 |
| 12 | Nutritional value of diets containing graded levels of wheat distillers grains with solubles fed to broiler chicks显示文摘 | THACKER P A WIDYARATNE G P | 2007 | Journal of the Science of Food and Agriculture2007，87，7： | 1 |
| 13 | Effect of enzyme supplementation on the performance of growing-finishing pigs fed barley-based diets supplemented with soybean meal or canola meal显示文摘 | Thacker P A | 2001 | J Anim Sci2001，14，7： | 1 |
| 14 | The role of pulmo- nary intravascular macrophages in porcine reproductive and re- spiratory syndrome virus infection显示文摘 | Thanawongnuwech R Halbur P Thacker E | 2000 | Anim Health Res Rev2000，1，： | 1 |
| 15 | Impact of gastric pH on dietary, enzyme activity and survivability in swine fed β-glucanase supplemented dlets显示文摘 | Baas T C and Thacker P A | 1996 | Can J Anita Sci1996，76，： | 1 |
| 16 | Effect of enzyme supplementation on the performance of growing-finishing pigs fed barley-based diets supplemented with soybean meal or canola meal 显示文摘 | Thacker P A | 2001 | J Anim Scien2001，14，7： | 1 |
| 17 | Use of the mobile nylon bag technique to determine the digestible energy con- tent of traditional and non-traditional feeds for swine显示文摘 | QIAO S Y THACKER P A | 2004 | Archives of Animal Nutrition2004，58，4： | 1 |
| 18 | Ahernatives to antibiotics as growth promoters for use in swineproduetion:A review显示文摘 | Thacker P A | 2013 | J Anim Sci Biotechnol2013，，4： | 1 |
| 19 | The Bhattacharyya metric as an absolute similarity measure for frequency coded data显示文摘 | Aherne F Thacker N Rockett P | 1998 | Statistical Techniquts in Pattern Recognition1998，34，4： | 1 |
| 20 | Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae 显示文摘 | THANAWONGNUWECH R THACKER B HALBUR P | 2004 | Clin Diagn Lab Immunol2004，11，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员