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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score. | Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Critical Care Medicine2021，10，6： | 9 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan显示文摘 | Hsueh P R Teng L J Chen C Y | 2002 | Emerg Infect Dis2002，8，8： | 1 |
| 5 | Focused on beam fabrication of thermally actuated bimorph cantilever 显示文摘 | TENG J PREWETT P D | 2005 | Sensors Actuators: A2005，，： | 1 |
| 6 | Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua County in Taiwan 显示文摘 | LIN Y P TENG T P CHANG T K | 2002 | Landscape and Urban Planning2002，62，1： | 1 |
| 7 | A simplified preparation of mesoporous carbon and the examination of the carbon accessibility for electric double layer formation显示文摘 | LIU H Y WANG K P TENG H | 2005 | Carbon2005，43，3： | 1 |
| 8 | Intelligent controlled- wind-turbine emulator and induction-generator system using RBFN显示文摘 | Lin F J Teng L T Shieh P H | 2006 | IEEE Proceedings of Electric Power Applications2006，153，4： | 1 |
| 9 | Microfluidics assisted synthesis and hioevaluation of sinomenine derivatives as antiinflammatory agents显示文摘 | Jin J Teng P Liu H L | 2013 | Eur J Med Chem2013，62，： | 1 |
| 10 | Controlled-size nanocapsules显示文摘 | Dravid V P Host J J Teng M H | 1995 | Nature1995，374，6523： | 1 |
| 11 | On the microsegregration of Ti-45Al-(8-9)Nb-(W,B,Y)alloy显示文摘 | Xu X J Lin J P Teng Z K | 2007 | Materials Letters2007，61，2： | 1 |
| 12 | Rest chest pain, negative treadmill exercise electrocardiogram and reverse redistribution in dipyridamole myocardial perfusion imaging might be the features of coronary artery spasm显示文摘 | XIANG D C YIN J L TENG A P | 2007 | Clin Cardiol2007，30，10： | 1 |
| 13 | Effect of film-hole shape on turbine-blade heat-transfer coefficient distribution 显示文摘 | TENG S HAN J C POINSATTE P E | 2001 | Jour- nal of Thermophysics and Heat Transfer2001，15，3： | 1 |
| 14 | Investigation of a nano- suspension stabilized by Soluplus to improve bioavailability 显示文摘 | Yang H Teng F Wang P | 2014 | Int JPharm2014，477，12： | 1 |
| 15 | Management of ovarian cancer by operative laparoscope显示文摘 | Amara P Teng N | 1995 | laparoscopy Gyneld1995，2，2： | 1 |
| 16 | Electrochemical responses from surface oxides present on HNO3-treated carbons显示文摘 | Cheng P Teng H | 2003 | Carbon2003，41，11： | 1 |
| 17 | Analysis of residual stresses and distortion in T-joint filler welds显示文摘 | Teng T L Fung C P Chang P H | 2001 | Intemational Journal of Pressure Vessel and Piping2001，78，： | 1 |
| 18 | Combined-stage sintering model 显示文摘 | Hansen J D Rusin R P Teng M H | 1992 | J Am Ceram Soc1992，75，5： | 1 |
| 19 | Liver ab- scess due to Neisseria sieea after repeated transcathe- ter arterial embolization显示文摘 | CHUNG H C TENG L J HSUEH P R | 2007 | J Med Microbiol2007，56，： | 1 |
| 20 | Bond-slip models for FRP sheets/plates bonded to concrete显示文摘 | Lu X Z Teng J G Ye L P | 2005 | Engineering Structures2005，27，6： | 1 |
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