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| 1 | Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in children显示文摘AIM: To assess the necessity of esophagogastroduodenoscopy (EGD) to predict the outcome of caustic ingestion in children. METHODS: The study included 206 children who underwent EGD because of ingestion of caustic substances between January 2005 and August 2010. Retrospective analysis of data of the patients was performed. RESULTS: The male/female ratio was 1.6 and mean age was 38.1 ± 28.8 mo. The caustic substances were acidic in 72 (34.9%) cases, alkaline in 56 (27.2%), liquid household bleach in 62 (30.1%), and unknown in 16 (7.8%). Fifty-seven (27.7%) patients were symptom-free. Significant clinical findings were observed in 149 (72.3%) patients. Upper gastrointestinal endoscopy findings of esophageal injury were grade 0 in 86 (41.7%) patients, grade 1 in 49 (23.8%), grade 2a in 42 (20.4%), grade 2b in 28 (13.6%), and grade 3a in 1 (0.5%) patient. 35 patients with grade 2a, 2b, and 3a injuries underwent esophageal dilation at second week of ingestion. Esophageal stricture, which necessitated a regular dilation program developed in 13 of the aforementioned 35 patients. There is no statistically significant difference in the rate of development of esophageal stricture between the patients who ingested acidic (15.3%) and alkaline (8.9%) substances (P = 0.32). Severe gastric injury was detected in 38 (18.5%) patients. The rate of development of gastric injury was significantly higher in the acidic group (14%) than in the alkaline group (2.9%) (P = 0.001). Out of 149 patients with clinical findings, 49 (32.9%) patients had no esophageal injury and 117 (78.5%) patients had no gastric lesion. Esophageal and severe gastric injuries were detected in 20 (35.1%) and 8 (14%) of patients with no clinical findings respectively. Pyloric stenosis developed in 6 patients. Pyloric obstruction improved with balloon dilation in 2 patients. Mean hospitalization time were 1.2 ± 0.5 d for grade 0 and 2.3 ± 5 d for grade 1 and 6.3 ± 6.2 d for grade 2a and 15.8 ± 18.6 d for grade 2b. It was significantly longer for patients with grade 2a and 2b injuries (P = 0.000). CONCLUSION: Endoscopy is an effective technique for determining the presence of esophageal and gastric damage and to avoid unnecessary treatment in patients with no or mild injury. | Abdulkerim Temiz Pelin Oguzkurt Semire Serin Ezer Emine Ince Akgun Hicsonmez | 2012 | World Journal of Gastroenterology2012，18，10： | 8 |
| 2 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 3 | The Effect of Counter-face Roughness on the Tribological Behavior of Filled and Unfilled PTFE显示文摘 | Zeynep Parlar Shahrad Samankan Vedat Temiz | 2015 | Journal of Mechanics Engineering and Automation2015，5，11： | 2 |
| 4 | Fortification of Yoghurt with Calcium Salts and Its Effect on Starter Microorganisms and Yoghurt Quality显示文摘 | PIRKUL T TEMIZ A ERDEM Y K | 1997 | International Dairy Journal1997，7，89： | 1 |
| 5 | A new material for prevention of peritendinous fibrotie adhesions' after tendon repair: oxidised regenem ted cellulose(Interceed),all absorbable adhesion barrier显示文摘 | Temiz A Ozturk C Bakunov A | 2008 | hit Orthop2008，32，3： | 1 |
| 6 | Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells 显示文摘 | Lee M E Temizer D H Clifford J A | 1991 | J Biol Chem1991，266，16： | 1 |
| 7 | Relationship between the serum alanine aminotransferase level at the end of interferon treatment and histologic changes in wild-type and precore mutant hepatitis B virus infections显示文摘 | BAYRAKTAR Y KOSEOGLU T TEMIZER A | 1996 | J Viral Hepat1996，3，3： | 1 |
| 8 | The effects of splenectomy on lipid peroxidation and neuronal loss in experimental spinal cord ischemia/reperfusion injury显示文摘 | Temiz C Solmaz I Tehli O | | 0，，： | 1 |
| 9 | The effect of fineness on the properties of the blended cements incorporating ground granulated blast furnace slag and ground basaltic pumice显示文摘 | Hanifi Binici Hu seyin Temiz Mehmet M Ko se | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 10 | Fuzzy branch-and-bound algorithm for flow shop seheduling显示文摘 | TEMIZ I.EROL S | | 0，，04： | 1 |
| 11 | A new modification of C-V flap technique in nipple reconstruction : rolled triangular der- mal-fat flaps显示文摘 | Temiz G Yesiloqlu N Sirinoqtlu H | 2015 | Aesthetic Plast Surg2015，39，1： | 1 |
| 12 | The value of sacral skih lesions in predicting occult spinal dysraphisrn in children with voiding dysfunction andnormal neurological examination显示文摘 | Tarcan T Tinay I Temiz Y | 2012 | J Pediatr Urol2012，8，1： | 1 |
| 13 | Partial purification and characterization of alkaline proteases from the Black Sea an- chovy (Engraulis encrasicholus) digestive tract显示文摘 | TEMIZ H USTUN N S TURHAN S | 2013 | African Jour- nal of Biotechnology2013，12，1： | 1 |
| 14 | Relationship between the serum alanine aminotransferase level at the end of interferon treatment and histologic changes in wild-type and precore mutant hepatitis B virus infections显示文摘 | BAYRAKTAR Y KOSEOGLU T TEMIZER A | 1996 | J Viral Hepat1996，3，： | 1 |
| 15 | 查看详情显示文摘 | I Temizer P Wriggers T J R Hughes | | 0，，： | 1 |
| 16 | A dynamical model of visually guided steering, obstacle avoidance, and route selection 显示文摘 | Fajen B R Warren W H Temizer S | 2003 | International Journal of Computer Vision2003，54，13： | 1 |
| 17 | Gas chromatog raphy-mass spectrometric analysis of clenbuterol from urine显示文摘 | KESKIN S ()ZER D TEMIZER A | 1998 | Journal of Pharmaceutical and Biomedical A- nalysis1998，18，45： | 1 |
| 18 | Endothelial function and germline ACE I/D,e NOS and PAI-1 gene profiles in patients with coronary slow flow in the Canakkale population:multiple thrombophilic gene profiles in coronary slow flow显示文摘 | Gazi E Temiz A Altun B | 2014 | Cardiovasc J Afr2014，25，1： | 1 |
| 19 | The effect of fineness on the properties of the blended cements incorporating ground granulated blast furnace slag and ground basaltic pumice 显示文摘 | Hanifi Binici Hu seyin Temiz Kose M M | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 20 | Comparison of recovery characteristics,postoperative nausea and vomiting,and gastrointestinal motility with total intravenous anesthesia with propofol versus inhalation anesthesia with desflurane for laparoscopic cholecystectomy:A randomized controlled st显示文摘 | Akkurt CO Temiz M Inanoglu K | | 0，，2： | 1 |
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