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| 1 | E2FBP1 antagonizes the p16^(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability显示文摘Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16 INK4A and promyelocytic leukemia protein (PML) in normal cells. E2F-binding protein 1 (E2FBP1), a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts. Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling. The cellular levels of p16 INK4A and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16 INK4A , but not p53 rescued senescent cells from growth arrest. Therefore, the premature senescence induced by E2FBP1 depletion is achieved through the p16 INK4A -Rb pathway. Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16 INK4A and Rb. These results suggest that E2FBP1 functions as a critical antagonist to the p16 INK4A -Rb tumor suppressor machinery by regulating PML stability. | Yayoi Fukuyo Akiko Takahashi Eiji Hara Nobuo Horikoshi Tej K. Pandita Takuma Nakajima | 2011 | International Journal of Oral Science2011，3，4： | 11 |
| 2 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 3 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 4 | New spinal robotic technologies显示文摘Robotic systems in surgery have developed rapidly. Installations of the da Vinci Surgical System® (Intuitive Surgical, Sunnyvale, CA,, USA), widely used in urological and gynecological procedures, have nearly doubled in the United States from 2010 to 2017. Robotics systems in spine surgery have been adopted more slowly;however, users are enthusiastic about their applications in this subspecialty. Spinal surgery often requires fine manipulation of vital structures that must be accessed via limited surgical corridors and can require repetitive tasks over lengthy periods of time — issues for which robotic assistance is well-positioned to complement human ability. To date, the United States Food and Drug Administration (FDA) has approved 7 robotic systems across 4 companies for use in spinal surgery. The available clinical data evaluating their efficacy have generally demonstrated these systems to be accurate and safe. A critical next step in the broader adoption of surgical robotics in spine surgery is the design and implementation of rigorous comparative studies to interrogate the utility of robotic assistance. Here we discuss current applications of robotics in spine surgery, review robotic systems FDA-approved for use in spine surgery, summarize randomized controlled trials involving robotics in spine surgery, and comment on prospects of robotic-assisted spine surgery. | Bowen Jiang Tej DAzad Ethan Cottrill Corinna CZygourakis Alex MZhu Neil Crawford Nicholas Theodore | 2019 | Frontiers of Medicine2019，13，6： | 5 |
| 5 | Genetic algorithms for computational materials discovery accelerated by machine learning显示文摘Materials discovery is increasingly being impelled by machine learning methods that rely on pre-existing datasets.Where datasets are lacking,unbiased data generation can be achieved with genetic algorithms.Here a machine learning model is trained on-the-fly as a computationally inexpensive energy predictor before analyzing how to augment convergence in genetic algorithm-based approaches by using the model as a surrogate.This leads to a machine learning accelerated genetic algorithm combining robust qualities of the genetic algorithm with rapid machine learning.The approach is used to search for stable,compositionally variant,geometrically similar nanoparticle alloys to illustrate its capability for accelerated materials discovery,e.g.,nanoalloy catalysts.The machine learning accelerated approach,in this case,yields a 50-fold reduction in the number of required energy calculations compared to a traditional“brute force”genetic algorithm.This makes searching through the space of all homotops and compositions of a binary alloy particle in a given structure feasible,using density functional theory calculations. | Paul C.Jennings Steen Lysgaard Jens Strabo Hummelshøj Tejs Vegge Thomas Bligaard | 2019 | npj Computational Materials2019，，1： | 5 |
| 6 | Effect of disturbance on biomass,production and carbon dynamics in moist tropical forest of eastern Nepal显示文摘Background: Forest biomass is helpful to assess its productivity and carbon(C) sequestration capacity. Several disturbance activities in tropical forests have reduced the biomass and net primary production(NPP) leading to climate change. Therefore, an accurate estimation of forest biomass and C cycling in context of disturbances is required for implementing REDD(Reducing Emissions from Deforestation and Forest Degradation) policy.Methods: Biomass and NPP of trees and shrubs were estimated by using allometric equations while herbaceous biomass was estimated by harvest method. Fine root biomass was determined from soil monolith. The C stock in vegetation was calculated by multiplying C concentration to dry weight.Results: Total stand biomass(Mg?ha^(-1)) in undisturbed forest stand(US) was 960.4 while in disturbed forest stand(DS) it was 449.1. The biomass(Mg?ha^(-1)) of trees, shrubs and herbs in US was 948.0, 4.4 and 1.4,respectively, while in DS they were 438.4, 6.1 and 1.2, respectively. Total NPP(Mg?ha^(-1)?yr^(-1)) was 26.58(equivalent to 12.26 Mg C?ha^(-1)?yr^(-1)) in US and 14.91(6.88 Mg C?ha^(-1)?yr^(-1)) in DS. Total C input into soil through litter plus root turnover was 6.78 and 3.35 Mg?ha^(-1)?yr^(-1)in US and DS, respectively.Conclusions: Several disturbance activities resulted in the significant loss in stand biomass(53 %), NPP(44 %), and C sequestration capacity of tropical forest in eastern Nepal. The net uptake of carbon by the vegetation is far greater than that returned to the soil by the turnover of fine root and litter. Therefore, both stands of present forest act as carbon accumulating systems. Moreover, disturbance reflects higher C emissions which can be reduced by better management. | Tilak Prasad Gautam Tej Narayan Mandal | 2016 | Forest Ecosystems2016，3，3： | 3 |
| 7 | Editorial: Post Operative Cognitive Dysfunction显示文摘 | Tej K Kaul Anurag Tawari | 2008 | J Anaesth Clin Pharmacol2008，24，2： | 1 |
| 8 | Prediction of Pneu- mococcal Conjugate Vaccine Effectiveness against Inva- sire Pneumococcal Disease Using Opsonophagocytic Activ- ity and Antibody Concentrations Determined by Enzyme- Linked Immunosorbent Assay with 22F Adsorption 显示文摘 | Schuerman L Wysocki J Tej edor JC | 2011 | Clin Vaccine Immunol2011，18，12： | 1 |
| 9 | DPPH antioxidant assay revisited显示文摘 | Om P. Sharma Tej K. Bhat | 2008 | Food Chemistry2008，，4： | 1 |
| 10 | DPPH antioxidant assay revisited显示文摘 | Om P Sharma Tej K Bhat | 2009 | Food Chemistry2009，113，4： | 1 |
| 11 | Managing urinary tract infections显示文摘 | Sermin AS Tej KM | 2011 | Pediatr Nephrol2011，26，11： | 1 |
| 12 | Hypoxia decreases podocyte expression of slit diaphragm proteins显示文摘 | Hong Lu Gaurav Kapur Tej K Mattoo | 2012 | International Jour- nal of Nephrology and Renovascular Disease2012，5，10： | 1 |
| 13 | Risk factors for postoperative delirium in ehterly patients with eoloreetal cancer显示文摘 | TeJ M Ikeda M Haraguchi N | 2010 | Surg Endosc2010，24，9： | 1 |
| 14 | Local sum uncertainty relations for angular momentum operators of bipartite permutation symmetric systems显示文摘We show that violation of the variance based local sum uncertainty relation(LSUR)for angular momentum operators of a bipartite system,proposed by Hofmann and Takeuchi[Phys.Rev.A 68032103(2003)],reflects entanglement in the equal bipartitions of an N-qubit symmetric state with even qubits.We establish the one-to-one connection with the violation of LSUR with negativity of covariance matrix[Phys.Lett.A 364203(2007)]of the two-qubit reduced system of a permutation symmetric N-qubit state. | I Reena H S Karthik J Prabhu Tej Sudha A R Usha Devi A K Rajagopal | 2022 | Chinese Physics B2022，31，6： | 1 |
| 15 | Cross-cultural competitive intelligence strategies 显示文摘 | Phani Tej Adidam | 2009 | Marketing Intelligence & Planning2009，27，5： | 1 |
| 16 | The role of new anesthetic agents显示文摘 | O'Keeffe NJ Healy TEJ | 1999 | Pharmacol Ther1999，84，3： | 1 |
| 17 | DPPH antioxidant assay revisited显示文摘 | Om P. Sharma Tej K. Bhat | 2008 | Food Chemistry2008，，4： | 1 |
| 18 | Unfolding the structural stability of nanoalloys via symmetry-constrained genetic algorithm and neural network potential显示文摘The structural stability of nanoalloys is a challenging research subject due to the complexity of size,shape,composition,and chemical ordering.The genetic algorithm is a popular global optimization method that can efficiently search for the ground-state nanoalloy structure.However,the algorithm suffers from three significant limitations:the efficiency and accuracy of the energy evaluator and the algorithm’s efficiency.Here we describe the construction of a neural network potential intended for rapid and accurate energy predictions of Pt-Ni nanoalloys of various sizes,shapes,and compositions.We further introduce a symmetry-constrained genetic algorithm that significantly improves the efficiency and viability of the algorithm for realistic size nanoalloys.The combination of the two allows us to explore the space of homotops and compositions of Pt-Ni nanoalloys consisting of up to 4033 atoms and quantitatively report the interplay of shape,size,and composition on the dominant chemical ordering patterns. | Shuang Han Giovanni Barcaro Alessandro Fortunelli Steen Lysgaard Tejs Vegge Heine Anton Hansen | 2022 | npj Computational Materials2022，，1： | 1 |
| 19 | Isthmic stenosis following radical trachelectomy显示文摘 | Selo-Ojeme DO Ind TEJ Shepherd JH | | 0，，03： | 1 |
| 20 | Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging显示文摘 | Behrens TEJ Johansen-Berg H Woolrich MW | 2003 | Nat Neurosci2003，6，7： | 1 |
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