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| 1 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 4 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 5 | The effect of uvulopalato-pharyngoplasty on the nasality of voice显示文摘 | Greene JS Zipfel TE Harlor M | 2004 | J Voice2004，18，3： | 1 |
| 6 | Cell migration and chimerism after whole-organ transplantation:the basis of graft acceptance显示文摘 | Starzl TE Demetris AJ Trucco M | 1993 | Hepatology1993，17，6： | 1 |
| 7 | Long-term resuits of laparoscopic adjustable gastric banding in patients lost to follow-up 显示文摘 | te Riele WW Boerma D Wiezer M J | 2010 | Br J Surg2010，97，10： | 1 |
| 8 | Comparison of fractional Inhibitory concentration index with response surface modeling for characterization of in vitro interaction of antifungals against itraconazole-susceptible and -resistant asporgillus fumigatus isolates 显示文摘 | TE DORSTHORST D T A VERWEIJ P E MEIS J F G M | 2002 | Antimicrob Agents Chemother2002，46，3： | 1 |
| 9 | Routing Techniques Used in Computer Communication Networks显示文摘 | SCHWARTZ M STERN TE | 1980 | IEEE Transactions on Communications1980，28，4： | 1 |
| 10 | Expression of microRNAs is dynamically regulated during eardiomyoeyte hypertrophy显示文摘 | Tatsuguchi M Seok HY Callis TE | 2007 | J Mol Cell Cardiol2007，42，6： | 1 |
| 11 | Home-based exercise training as maintenance after outpatient pulmonaryrehabilitation显示文摘 | du Moulin M Te K Wegscheider K | 2009 | Respiration2009，77，2： | 1 |
| 12 | Critical appraisal ofthe current practice in murine TNBS-induced colitis显示文摘 | te VeIde A A Verstege M I Hommes D W | 2006 | Inflamm Bowel Dis2006，12，10： | 1 |
| 13 | Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performan-ce traits in pigs显示文摘 | A J van Erp F L Hardem F J Verburg T H Meuwissen J HVeerkamp and M F te Pas | | 0，，04： | 1 |
| 14 | The medical interview: a core curriculum for residencies in internal medicine 显示文摘 | Lipkin M Jr Quill TE Napodano RJ | 1984 | Ann Intern Med1984，100，2： | 1 |
| 15 | Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis - related proteins, and transcription factor GATA - 4 显示文摘 | Vaskivuo Te Anttoncn M Hera R | 2001 | Clin Endocrinol Metab2001，86，7： | 1 |
| 16 | Inflammatory signal transduction in Crohn's disease and novel therapeutic approaches显示文摘 | Van Montfrans C Peppelenbosch M Te Velde A A | 2002 | Biochem Pharmacol2002，64，： | 1 |
| 17 | Unilateral partial he- mi-laminectomy for the removal of extra-and intramedullary tumours and AVMs 显示文摘 | Yasargil M J Tranmer BI Adamson TE | 1991 | Adv Tech Stand Neurosurg1991，18，： | 1 |
| 18 | Sortilins: new players in lipoprotein metabolism显示文摘 | Willnow TE Kjolby M Nykiaer A | 2011 | Curr Opin Lipidol2011，22，2： | 1 |
| 19 | High - frequency oscil- latory ventilation is not associated with increased risk of neuropa- thology compared with positive pressure ventilation: a preterm primate model显示文摘 | Loeliger M Inder TE Shields A | 2009 | Pediatr Res2009，66，5： | 1 |
| 20 | Sonar tracking of multiple targets using joint probabilistic data association显示文摘 | Formann TE Bar-Shalom Y Scheffe M | 1983 | IEEE Journal of Oceanic Engineering1983，8，3： | 1 |
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