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| 1 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 2 | Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration 显示文摘 | Ng CE Tang BL | 2002 | J Neurosci Res2002，67，5： | 1 |
| 3 | Nogo-A expression in mouse central nervous system neurons显示文摘 | Liu H Ng CE Tang BL | 2002 | Neurosci Lett2002，328，3： | 1 |
| 4 | Neural differentiation and potential use of stem cells from the human umbi- lical cord for central nervous system transplantation therapy显示文摘 | Low CB Liou YC Tang BL | 2008 | J Neurosci Res2008，86，8： | 1 |
| 5 | Genetic manipulation of neural stem cells for transplantation into the injured spinal cord 显示文摘 | Tang BL Low CB | 2007 | Cell Mol Neurobiol2007，27，1： | 1 |
| 6 | SIRT1,neuronal cell survival and the insulin/IGF-1aging paradox显示文摘 | Tang BL | 2006 | Neurobiol Aging2006，27，3： | 1 |
| 7 | Biomarkers of mild cognitive impairment and Alzheimer' s disease 显示文摘 | Tang BL Kumar R | 2008 | Ann Acad Med Singapore2008，37，5： | 1 |
| 8 | Genetic manipulation of neural stem cells for transplantation into the injured spinal cord 显示文摘 | Tang BL Low CB | 2007 | Cell Mol Neurobiol2007，27，1： | 1 |
| 9 | Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice显示文摘 | Liu BL Wu WW Tang N | 2005 | Planta Medica2005，71，5： | 1 |
| 10 | ADAMTS: A novel family of extracellular matrix proteases 显示文摘 | Tang BL | 2008 | Int J Biochem Cell Biol2008，33，35： | 1 |
| 11 | Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy 显示文摘 | Low CB Liu YC Tang BL | 2008 | J Neurosci Res2008，86，8： | 1 |
| 12 | Pulmonmy cryplococcosis in non AIDS patients 显示文摘 | Yu JQ Tang KJ Xu BL | 2012 | Braz J Infect Dis2012，16，6： | 1 |
| 13 | Coaxing bone marrow stromal mesenchymal stem cells towards neuronal differentiation: progress and uncertainties 显示文摘 | Chen Y Teng FY Tang BL | 2006 | Cell Mol Life Sci2006，63，： | 1 |
| 14 | Why do Nogo/Nogo-66 receptor gene knockouts result in inferior regeneration compared to treatment with neutralizing agents显示文摘 | Teng FY Tang BL | 2005 | J Neurochem2005，94，4： | 1 |
| 15 | 显示文摘 | Ng CE Tang BL | 2002 | Neurosci Res2002，67，5： | 1 |
| 16 | Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration显示文摘 | Nq CE Tang BL | 2002 | J Neurosci Res2002，67，5： | 1 |
| 17 | Why do Nogo/Nogo -66 receptor gene knock - outs result in inferior regeneration compared to treatment with neu - tralizing agents 显示文摘 | Teng FY Tang BL | 2005 | Neurochem2005，94，： | 1 |
| 18 | Nogos and the Nogo-66 receptor:factors inhibiting CNS neuron regeneration 显示文摘 | Ng CE Tang BL | 2002 | J Neurosci Res2002，67，5： | 1 |
| 19 | Inhibitors of neuronal regeneration:mediators and signaling mechanisms显示文摘 | Bor L Tang BL | 2003 | Neurochem Int2003，42，3： | 1 |
| 20 | Axonal regeneration in adult CNS neurons- signaling molecules and pathways 显示文摘 | Teng FY Tang BL | 2006 | J Neurochem2006，96，6： | 1 |
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