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| 1 | Biodegradable Materials for Bone Repairs:A Review显示文摘With attractive research and development of biomaterials,more and more opportunities have been brought to the treatments of human tissue repairs.The implant is usually no need to exist in the body accompanied with the recovery or regeneration of the tissue lesions,and the long-term effect of exotic substance to human body should be reduced as lower as possible.For this purpose,biodegradable materials,including polymers, magnesium alloys and ceramics,have attracted much attention for medical applications due to their biodegradable characters in body environment.This paper in turn introduces these three different types of widely studied biodegradable materials as well as their advantages as implants in applications for bone repairs.Relevant history and research progresses are summarized. | Lili Tan Xiaoming Yu Peng Wan Ke Yang | 2013 | Journal of Materials Science & Technology2013，29，6： | 24 |
| 2 | Allelopathic effects of extracts from Solidago canadensis L. against seed germination and seedling growth of some plants显示文摘To investigate the potential role of allelopathy in plant interference and in the successful invasion of alien species Solidago canadensis, aqueous an d ethanolic extracts from rhizomes, stems and leaves of S. canadensis were prepa red and used as treatment solutions to assess their effects on seed germination and seedling growth in four target species, mulberry (Morus alba); morning glory (Pharbitis nil), wheat(Triticum aestivum) and rape(Brassica campestris). Reducti on and/or growth in germination and growth of the target plant species in the pr esence of both aqueous and ethanolic extracts at different concentrations indica ted that the responses were species-specific and concentration-dependent. Genera lly, ethanolic extracts(especially from leaves) imposed stronger effects on both seed germination and seedling growth. Extracts with lower concentration at 0.00 1 g/ml dw could stimulate the seedling growth of rape and morning glory, whereas extracts at any given concentrations have inhibitory effects on wheat and mulbe rry. It is suggested that the aqueous and ethanolic extracts of all the three pa rts of S. canadensis have significant allelopathic effects. Although both inhibi tion and stimulation occurred in the germination and growth of the target specie s, extracts with higher concentrations definitely inhibit seed germination and s eedling growth of all target plants. We suggest that allelopathy plays a more im portant role than other mechanisms do in the out-competition of S. canadensis ov er other plants, and make it invasive in new habitats. | SUN Bing-yao TAN Jian-zhong WAN Zhi-gang GU Fu-gen ZHU Ming-de | 2006 | Journal of Environmental Sciences2006，18，2： | 20 |
| 3 | Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability:A Review显示文摘Magnesium(Mg) and its alloys as a novel kind of biodegradable material have attracted much fundamental research and valuable exploration to develop its clinical application. Mg alloys degrade too fast at the early stage after implantation, thus commonly leading to some problems such as osteolysis, early fast mechanical loss, hydric bubble aggregation, gap formation between the implants and the tissue. Surface modification is one of the effective methods to control the degradation property of Mg alloys to adapt to the need of organism. Some coatings with bioactive elements have been developed, especially for the micro-arc oxidation coating, which has high adhesion strength and can be added with Ca, P, and Sr elements. Chemical deposition coating including bio-mimetic deposition coating, electro-deposition coating and chemical conversion coating can provide good anticorrosion property as well as better bioactivity with higher Ca and P content in the coating. From the biodegradation study, it can be seen that surface coating protected the Mg alloys at the early stage providing the Mg alloy substrate with lower degradation rate. The biocompatibility study showed that the surface modification could provide the cell and tissue stable and weak alkaline surface micro-environment adapting to the cell adhesion and tissue growth.The surface modification also decreased the mechanical loss at the early stage adapting to the loadbearing requirement at this stage. From the interface strength between Mg alloys implants and the surrounding tissue study, it can be seen that the surface modification improved the bio-adhesion of Mg alloys with the surrounding tissue, which is believed to be contributed to the tissue adaptability of the surface modification. Therefore, the surface modification adapts the biodegradable magnesium alloys to the need of biodegradation, biocompatibility and mechanical loss property. For the different clinical application, different surface modification methods can be provided to adapt to the clinical requirements for the Mg alloy implants. | Peng Wan Lili Tan Ke Yang | 2016 | Journal of Materials Science & Technology2016，32，9： | 19 |
| 4 | Effects of long-term straw return on soil organic carbon fractions and enzyme activities in a double-cropped rice paddy in South China显示文摘Long-term straw return is an important carbon source for improving soil organic carbon(SOC) stocks in croplands, and straw removal through burning is also a common practice in open fields in South China. However, the specific effects of long-term rice straw management on SOC fractions, the related enzyme activities and their relationships, and whether these effects differ between crop growing seasons remain unknown. Three treatments with equal nitrogen, phosphorus, and potassium nutrient inputs, including straw/ash and chemical nutrients, were established to compare the effects of straw removal(CK), straw return(SR), and straw burned return(SBR). Compared to CK, long-term SR tended to improve the yield of early season rice(P=0.057), and significantly increased total organic carbon(TOC) and microbial biomass carbon(MBC) in double-cropped rice paddies. While SBR had no effect on TOC, it decreased light fraction organic carbon(LFOC) in early rice and easily oxidizable organic carbon(EOC) in late rice, significantly increased dissolved organic carbon(DOC), and significantly decreased soil p H. These results showed that MBC was the most sensitive indicator for assessing changes of SOC in the double-cropped rice system due to long-term straw return. In addition, the different effects on SOC fraction sizes between SR and SBR were attributed to the divergent trends in most of the soil enzyme activities in the early and late rice that mainly altered DOC, while DOC was positively affected by β-xylosidase in both early and late rice. We concluded that straw return was superior to straw burned return for improving SOC fractions, but the negative effects on soil enzyme activities in late rice require further research. | HUANG Wan WU Jian-fu PAN Xiao-hua TAN Xue-ming ZENG Yong-jun SHI Qing-hua LIU Tao-ju ZENG Yan-hua | 2021 | Journal of Integrative Agriculture2021，20，1： | 16 |
| 5 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 6 | Cadmium accumulation and tolerance of two castor cultivars in relation to antioxidant systems显示文摘To investigate the effects of Cd on tolerance and antioxidant activities of castor, two different castor(Ricinus communis L.) cultivars(Zibo No. 5 and Zibo No. 8) were used for a hydroponic experiment(0, 1 and 2 mg/L Cd) and a pot experiment using Cd-contaminated soil(34 mg/kg) with the addition of ethylenedinitrilotetraacetic acid(EDTA). The results indicated that there were significant differences between the two cultivars with respect to Cd uptake in shoots(113–248 mg/kg for Zibo No. 5 and 130–288 mg/kg Zibo No. 8), biomass tolerance indexes(64.9%–74.6% for Zibo No. 5 and 80.1%–90.9% for Zibo No. 8) in the hydroponic experiment and survival rates(0% for Zibo No. 5 and 100% for Zibo No. 8)determined by the addition of EDTA in the pot experiment, suggesting that Zibo No. 8 has higher tolerance than Zibo No. 5. Moreover, the castor cultivars have low bioconcentration factors(4.80% for Zibo No. 5 and 5.43% for Zibo No. 8) and low translocation factors(<1%).Consequently, Zibo No. 8 can participate in Cd phytostabilization in highly Cd-polluted areas. The results indicated that glutathione(GSH) as a non-enzymatic antioxidant, and antioxidant enzymes including superoxide dismutase(SOD), catalase(CAT) and guaiacol peroxidase(GPX), were cultivar- and dose-dependent. The higher tolerance of Zibo No. 8compared with Zibo No. 5 can be attributed to the higher GSH levels in the root and higher GPX activity in the leaf. | Hanzhi Zhang Qingjun Guo Junxing Yang Tongbin Chen Guangxu Zhu Marc Peters Rongfei Wei Liyan Tian Chunyu Wang Deyun Tan Jie Ma Gangming Wang Yingxin Wan | 2014 | Journal of Environmental Sciences2014，26，10： | 15 |
| 7 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 8 | Understanding hydraulic fracture propagation behavior in tight sandstone–coal interbedded formations: an experimentalinvestigation显示文摘Whether hydraulic fractures could connect multiple gas zones in the vertical plane is the key to fracturing treatment to jointly exploit coalbed methane and tight sandstone gas through integrative hydraulic fracturing in tight sandstone–coal interbedded formations. Laboratory true triaxial hydraulic fracturing experiments were conducted on layered specimens with di erent combination types of natural sandstone and coal to simulate the propagation behavior of hydraulic fractures. The effects of the fracture initiation position, fracturing fluid viscosity and injection rate were discussed. The results showed that di erent fracture morphologies could be found. When initiating from coal seams, three patterns of fracture initiation and propagation were obtained:(1) The main hydraulic fracture initiated and propagated along the natural fractures and then diverged due to the effects of in situ stress and formed secondary fractures.(2) The hydraulic fracture initiated and propagated in the direction of the maximum horizontal stress.(3) Multiple fractures initiated and propagated at the same time. With the same fracturing fluid viscosity and injection rate, the hydraulic fractures initiating in sandstones had greater chances than those in coal seams to penetrate interfaces and enter neighboring layers. Excessively small or large fracturing fluid viscosity and injection rate would do harm to the vertical extension height of the induced fracture and improvement of the stimulated reservoir volume. Compared with operation parameters(fracturing fluid viscosity and injection rate), the natural weak planes in coals were considered to be the key factor that a ected the fracture propagation path. The experimental results would make some contributions to the development of tight sandstone–coal interbedded reservoirs. | Peng Tan Yan Jin Liang Yuan Zhen-Yu Xiong Bing Hou Mian Chen Li-Ming Wan | 2019 | Petroleum Science2019，16，1： | 14 |
| 9 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 10 | The Trickle-dow n Effect of Fin tech Developme nt:From the Perspective of Urbanization显示文摘The emergence of a digital divide or a lack of internet access may hinder urbanization and adversely affect growth.However,fintech development can help to improve the accessibility and affordability of financial services,particularly for sections of the population formerly excluded from such services.Improved access is expected to stimulate the growth essential for promoting urbanization,possibly alleviating the negative impacts of a digital divide and creating a trickle-down effect.This paper is among the first to investigate the effect of fintech development on urbanization,as indicated by labor transfer from agricultural to non-agricultural sectors in China.It is found that:(i)the digital divide hindered,while fintech development contributed to urbanization;(ii)the positive effect of fintech development on urbanization affects individuals both with and without access to the internet,yielding the so-called trickledown ejfect and thus helping to alleviate the negative consequences of a digital divide;and(Hi)regarding transmission mechanisms,fintech development helps to generate additional jobs and raise income in non-agricultural sectors,stimulating urbanization even for those without access to the internet. | Xun Zhang Ying Tan Zonghui Hu Chen Wang Guanghua Wan | 2020 | China & World Economy2020，28，1： | 13 |
| 11 | Degradation and biological properties of Ca-P contained micro-arc oxidation self-sealing coating on pure magnesium for bone fixation显示文摘Poor corrosion resistance is one of the main disadvantages for biodegradable magnesium-based metals,especially applied for bone fixation,where there is a high demand of bio-mechanical strength and stability.Surface coating has been proved as an effective method to control the in vivo degradation.In this study a Ca-P self-sealing micro-arc oxidation(MAO)coating was studied to verify its efficacy and biological properties by in vitro and in vivo tests.It was found that the MAO coating could effectively retard the degradation according to immersion and electrochemical tests as well as 3D reconstruction by X-ray tomography after implantation.The MAO coating exhibited no toxicity and could stimulate the new bone formation.Therefore,the Ca-P self-sealing MAO coating could be a potential candidate for application of biodegradable Mg-based implant in bone fixations. | Weidan Wang Peng Wan Chen Liu Lili Tan Weirong Li Lugee Li Ke Yang | 2015 | Regenerative Biomaterials2015，2，2： | 11 |
| 12 | The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages(TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1(tumor-inhibitory) phenotype or M2(tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine(TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed. | WAN Liang-Qin TAN Yan JIANG Miao HUA Qian | 2019 | Chinese Journal of Natural Medicines2019，17，10： | 11 |
| 13 | 影响慢性阻塞性肺病急性加重患者生活质量的危险因素显示文摘目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治呼吸问卷测定生活质量,并收集了患者的临床性状、社会性状和照料因素。结果196例患者中,吸烟、抑郁及嗜用镇痛剂、安眠药相当普遍,而完成肺康复、接种流感病毒疫苗和肺炎球菌疫苗以及看护支持却很少。生活质量的症状域均值为55.9,活动域均值为65,影响域均值为32.9,总体均值为46.5。多变量分析显示慢性黏液高分泌症、男性、抑郁、前1年多次入院和治疗依顺性差与症状域值低下独立显著相关;前1年多次入院、抑郁、严重气促和72岁以上老年与活动域值低下独立显著相关;抑郁、前1年多次入院、严重气促、病程长和重度吸烟与影响域值低下独立显著相关;抑郁、前1年多次入院、严重气促和病程长与总体数值低下独立显著相关(P<0.05)。结论COPD急性加重患者的生活质量低下与COPD严重程度、患者精神抑郁状态及照料这些可改善因素有关。 | 曹振英 Tan Wan Cheng Ng Tze Pin | 2005 | 上海第二医科大学学报2005，25，7： | 10 |
| 14 | Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines显示文摘Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the | TAN Long SANG Zhong Na SHEN Jun WU Yun Tang YAO Zhai Xiao ZHANG Jin Xiang ZHAO Na ZHANG Wan Qi | 2013 | Biomedical and Environmental Sciences2013，26，11： | 10 |
| 15 | New Cutting Force Modeling Approach for Flat End Mill显示文摘A new mechanistic cutting force model for flat end milling using the instantaneous cutting force coefficients is proposed. An in-depth analysis shows that the total cutting forces can be separated into two terms: a nominal component independent of the runout and a perturbation component induced by the runout. The instantaneous value of the nominal component is used to calibrate the cutting force coefficients. With the help of the perturbation component and the cutting force coefficients obtained above, the cutter runout is identified. Based on simulation and experimental results, the validity of the identification approach is demonstrated. The advantage of the proposed method lies in that the calibration performed with data of one cutting test under a specific regime can be applied for a great range of cutting conditions. | WAN Min ZHANG Wei-hong TAN Gang QIN Guo-hua | 2007 | Chinese Journal of Aeronautics2007，20，3： | 8 |
| 16 | Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture显示文摘We established a stroke-prone renovascular hypertensive rat model by bilateral constriction of the renal artery with sliver loop clips. After ten weeks, middle cerebral artery occlusion was induced for 2 hours. The rats then received electro-acupuncture at Baihui (DU 20) and Dazhui (DU 14) after onset of ischemia for 30 days. In situ hybridization study showed that electroacupuncture significantly reduced the number of neurocan mRNA-positive cells in the ischemic penumbra and hippocampal tissues of rats. Electron microscopy results demonstrated that the structure of neurons and blood vessels in the ischemic tissues were restored with electroacupuncture. Overall, these data suggest that electroacupuncture may protect neurons against ischemic reperfusion injury in stroke-prone renovascular hypertensive rats, which may be regulated by downregulation of expression of nerve inhibitory factor neurocan mRNA. | Feng Tan Saiying Wan Haike Wu Qiwen HUO Jinliang Wang Wenlin Chen Meifeng Fang Xiaolin Liu Xuewen Wang Jingbo Sun | 2011 | Neural Regeneration Research2011，6，36： | 8 |
| 17 | Update in management of hepatocellular carcinoma in Eastern population显示文摘Hepatocellular carcinoma(HCC) is one of the commonest malignant tumours in the East. Although the management of HCC in the West is mainly based on the Barcelona Clinic for Liver Cancer staging, it is considered too conservative by Asian countries where the number of HCC patients is huge. Scientific and clinical advances were made in aspects of diagnosis, staging, and treatment of HCC. HCC is well known to be associated with cirrhosis and the treatment of HCC must take into account the presence and stage of chronic liver disease. The major treatment modalities of HCC include:(1) surgical resection;(2) liver transplantation;(3) local ablation therapy;(4) transarterial locoregional treatment; and(5) systemic treatment. Among these, resection, liver transplantation and ablation therapy for small HCC are considered as curative treatment. Portal vein embolisation and the associating liver partition with portal vein ligation for staged hepatectomy may reduce dropout in patients with marginally resectable disease but the midterm and long-term results are still to be confirmed. Patient selection for the best treatment modality is the key to success of treatment of HCC. The purpose of current review is to provide a description of the current advances in diagnosis, staging, preoperative liver function assessment and treatment options for patients with HCC in the east. | Kevin Ka Wan Chu Tan To Cheung | 2015 | World Journal of Hepatology2015，7，11： | 8 |
| 18 | Fabrication and Evaluation of a Bioactive Sr–Ca–P Contained Micro-Arc Oxidation Coating on Magnesium Strontium Alloy for Bone Repair Application显示文摘Considering the compatibility between degradation and bioactivity of magnesium-based implants for bone repair, micro-arc oxidation is used to modify the magnesium alloy surface in aqueous electrolytes,allowing strontium, calcium, and phosphorus to be incorporated into the coating. The thickness, composition, morphology and phase of this Sr–Ca–P containing coating are characterized by scanning electron microscopy equipped with energy dispersive X-ray spectrometer and X-ray diffraction. The in vitro and in vivo degradation of the coating is evaluated by immersion test, electrochemical test and implantation test. Moreover, the cytocompatibility is tested with osteoblast cell according to ISO 10993. The results show that Sr, Ca and P elements are incorporated into the oxide coating, and a refined structure with tiny discharging micro-pores is observed on the surface of the coating. The Sr–Ca–P coating possesses a better corrosion resistance in vitro and retards the degradation in vivo. Such coating is expected to have significant medical applications on orthopedic implants and bone repair materials. | Junjie Han Peng Wan Yu Sun Zongyuan Liu Xinmin Fan Lili Tan Ke Yang | 2016 | Journal of Materials Science & Technology2016，32，3： | 8 |
| 19 | Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression显示文摘运动不足是胆石疾病的普通症状,它被空隙的象 Cajal 一样房间(ICLC ) 的损失在胆囊伴随。Ursodeoxycholic 酸(UDCA ) 广泛地在治疗胆石疾病被使用,并且除了它溶解胆石的能力显示出 anti-apoptotic 和反煽动性的效果。在这研究,我们与胆石在畿尼猪在 ICLC 上调查了 anti-apoptotic 和 UDCA 的反煽动性的效果。畿尼猪被喂为 8 个星期到的一本高胆固醇的食谱导致胆石的形成。一组动物被管理 UDCA (在跟随 553 的 consultation.ResultsA 总数的临床的管理的一个变化请教的 50 mgith 为 268 个婴儿被执行(gestational 年龄:在到控制的 CP 和 RAP.ResultsCompared 之间的 27ffect QOL 预言者(51.0ook 建筑群产品,它证明 GaoFen-3 是 SAR 图象在有另外的二幅 C 乐队 SAR 图象和它 3.5 dB 的 RR 会系统设计的一样的优秀水平。然后,这些 thr 的反散射系数?? | Jiang-fan WAN Shi-feng CHU Xin ZHOU Yue-ting LI Wen-bin HE Feng TAN Piao LUO Qi-di AI Qi WANG Nai-hong CHEN | 2018 | Acta Pharmacologica Sinica2018，39，9： | 8 |
| 20 | Rapid measurement of indocyanine green retention by pulse spectrophotometry: a validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma显示文摘BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly- developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON , one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73.CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. | Tan To Cheung See Ching Chan Kenneth SH Chok Albert CY Chan Wan Ching Yu Ronnie TP Poon Chung Mau Lo Sheung Tat Fan | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 8 |
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