|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | A newly updated and annotated checklist of Chinese Mosses 显示文摘 | Redfearn PL Tan BC He S 1996 | 1996 | Journ Hattori Bot Lab1996，79，： | 1 |
| 3 | Arterial embolization forbleeding following hysterectomy for intractable postpartumhemorrhage显示文摘 | Oei PL Chua S Tan L | 1998 | Int J Gynecol Obs1998，62，： | 1 |
| 4 | A newly update and annotated checklist of Chinese mosses显示文摘 | Redfeam PL Tan BC & SH 1996 | 1996 | Hattori Bot Lab1996，79，： | 1 |
| 5 | The effect of delipidated deglycolipidated(DDMV) and heat-killed Mycobacterium vaccae in asthma显示文摘 | Shirtcliffe PM Easthope SE ChengS Weatherall M Tan PL LeGros G | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 6 | An esthetic comparison of a metal ceramic crown and cast metal abutment with an all - ceramic crown and zirconia abutment: a clinical report显示文摘 | Tan PL Dunne JT Jr | 2004 | J Prosthet Dent2004，91，： | 1 |
| 7 | In vitro fracture resistance of endodontically treated central incisors with varying ferrule heights and configu- rations显示文摘 | Tan PL Aquilino SA Gratton DG | 2005 | J Prosthet Dent2005，93，4： | 1 |
| 8 | Recent developments in understanding the pathophysiology of elevated intraocular pressure 显示文摘 | Tan JC Peters DM Kaufman PL | 2006 | Curr Opin Ophthalmol2006，17，2： | 1 |
| 9 | Twin studies of immunogenicity-determining the genetic contribution to vaccine failure显示文摘 | Tan PL Jacobson RM Poland GA | 2001 | Vaccine2001，19，1719： | 1 |
| 10 | A newly updated and annotated checklist of Chinese mosses 显示文摘 | Redfearn PL Tan BC He S 1996 | 1996 | Journal of the Hattori Botanical Laboratory1996，79，： | 1 |
| 11 | Simple surgery to improve flexion deficit resulting from mal-union of fracture neck of the proximal phalanx-a case report显示文摘 | Kang YC Tan PL | 2014 | Hand Surg2014，19，1： | 1 |
| 12 | B55β-associated PP2a complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer显示文摘 | Tan J Lee PL Li Z | 2010 | Cancer Cell2010，1618，5： | 1 |
| 13 | CT 'invisihle' lesion of the major salivary glands a diagnostic pitfall of contrast-enhanecd CT显示文摘 | Kei PL Tan TY | 2009 | Clin Ra- diol2009，64，7： | 1 |
| 14 | Inhaled fluticasone inbronchiectasis: a 12 month study 显示文摘 | Tsang KW Tan KC Ho PL | 2005 | Thorax2005，60，： | 1 |
| 15 | Central venous catheters:the role of radiology显示文摘 | Tan PL Gibson M | | 0，，01： | 1 |
| 16 | Arterial embolization for bleeding following hysterectomy for intractable postpartum hemorrhage 显示文摘 | Oei PL Chua S Tan L | 1998 | Int J Gynaecol Obstet1998，62，： | 1 |
| 17 | Early deep vein thrombosis: incidence in Asian stroke patients 显示文摘 | Tan SS Venketasunramanian N Ong PL | 2007 | Ann Acad Med Singapore2007，36，： | 1 |
| 18 | Life-threatening perineal sepsis after rubber band ligation of haemorrhoids 显示文摘 | Sim HL Tan KY Poon PL | 2009 | Tech Coloproctol2009，13，： | 1 |
| 19 | Early deep vein thrombosis:incidence in Asian stroke patients 显示文摘 | Tan SS Venketasunramanian N Ong PL | 2007 | Am Acad Med Singapore2007，36，10： | 1 |
| 20 | Inhaled fluticasone in bornchicetasis : a 12 month study 显示文摘 | Tsang KW Tan KC Ho PL | 2005 | Thorax2005，60，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员