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| 1 | Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study显示文摘Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;http://gffzz90ed6ce9d87f4798sbcxc66uxw5np6cnx.ffgz.tsg.suse.edu.cn Clinical Trial Registry No.ChiCTR-TRC-14004276;http://gffzz62a03ee25e6f4a77hbcxc66uxw5np6cnx.ffgz.tsg.suse.edu.cn/enindex.aspx. | Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT Study Team | 2020 | Chinese Medical Journal2020，，24： | 10 |
| 2 | 提高国家工科化学基地建设效益的探索与实践显示文摘本文介绍了中南大学在提高国家工科基础课程化学教学基地建设效益的过程中所取得的部分经验 ,针对新形势下基地建设存在的普遍性问题 ,进行了分析并提出了解决的办法。这些经验为基地的进一步建设深入提供了思路和借鉴。 | National engineering chemistry talent training base of CSU | 2003 | 现代大学教育2003，19，5： | 2 |
| 3 | Reactive oxygen species:the unavoidable environmental insult? 显示文摘 | Gracy R W Talent J M Kong Y | 1999 | Mutation Research1999，428，12： | 1 |
| 4 | Glycogen storage disease in adults显示文摘 | Talente GM Coleman RA Alter C | 1994 | Ann Intern Med1994，120，： | 1 |
| 5 | Reactive oxygen species: the unavoidable environmental insult? 显示文摘 | Gracy RW Talent JM Kong Y | 1999 | Mutat Res1999，428，12： | 1 |
| 6 | Effect of temperature on toxicity of a natu-ral pyrethrin pesticide to green an ole lizards (A noliscarolinensis) 显示文摘 | Talent L G | 2005 | Environmental Toxicology and Chem-istry2005，24，12： | 1 |
| 7 | Soil ingestion may be an impor-tant route for the uptake of contaminants by some rep-tiles 显示文摘 | Rich C N Talent L G | 2009 | Environmental Toxicology and Chemistry2009，28，2： | 1 |
| 8 | Heidrick & Struggles 显示文摘 | Mapping Global Talent | 2007 | Economist Intelligence Unit2007，，： | 1 |
| 9 | Chemiluminescent standards for quantitive comparison of two-dimensional electrophoresis western blots 显示文摘 | Conrad C C Malakowsky C A Talent J | 2001 | Proteomics2001，1，： | 1 |
| 10 | Effect of acute ex-posure to malathion and lead on sprint performance ofthe western fence lizard (Sceloporus occidentalis) 显示文摘 | Holem R Hopkins W A Talent L G | 2006 | Archives of Environmental Contamination and Toxicol-ogy2006，51，1： | 1 |
| 11 | Effects of re-peated e?q)osure to malathion on growth, food con-sumption, and locomotor performance of the westernfence lizard (Sceloporus occidentalis) 显示文摘 | Holem R R Hopkins W A Talent L G | 2008 | EnvironmentalPollution2008，152，1： | 1 |
| 12 | Effect of active-site modification on the terminal marking deamindation of triosephosphate isomerase显示文摘 | TALENT J M ZVAIGZNE A I AGRAWAL N | 1997 | Archives of Biochemistry and Biophysics1997，340，1： | 1 |
| 13 | 2018年度中关村高科技企业人才发展调查报告显示文摘在中关村科技园区管理委员会的指导下,中关村人才协会委托专业机构于2017年7月开始对北京、上海、深圳、天津、河北等地的高科技企业及从业者进行了有关人才发展的调查。调查内容包括有关地区高科技企业的中高级人才状况和人力资源发展环境、高科技企业的用人环境、高科技企业及工作人员的社会公共服务需求、企业人才招聘及保留需求状况和发展趋势、高科技企业及人员的培训需求等。调查发现,各地高科技企业均存在高级人才招聘相对较难等问题,网络招聘成为人才招聘的首要渠道;企业内部知识分享和内部培训是人才培训的主要方式;对中高级技术人员和中层管理人员的激励普遍以年底奖金为主;企业技术人才离职率高于管理人员;企业与人才对绩效考核结果的认可程度有待提高;企业中高级人才对本地区、本园区发展的信心,以及对政府管理能力和服务意识的评价总体积极,但仍有较大改进空间。 | Zhongguancun Talent Association | 2018 | 中国人事科学2018，0，8： | 1 |
| 14 | Oral polymeric N-acetyl-D- glucosamine and osteoarthritis显示文摘 | Rubin BR Talent JM Kongtawelert P | 2001 | J Am Osteopath Assoc2001，101，6： | 1 |
| 15 | A review of the chemistry of the genus Crataegus 显示文摘 | Edwards J E Brown P N Talent N | 2012 | Phytochemistry2012，79，： | 1 |
| 16 | Identification of oxidized plasma proteins in Alzheimer's disease 显示文摘 | Choi J Malakowsky CA Talent JM | 2002 | Biochem Biophys Res Commun2002，293，5： | 1 |
| 17 | Character selection during integrative taxonomic identification:'best characters'显示文摘 | Talent N Dickinson RB Dickinson TA | 2014 | Biodivers Informatics2014，9，： | 1 |
| 18 | A review of the chemistry of the genus Crataegus显示文摘 | Edwardsa JE Brown PN Talent N | | 0，，03： | 1 |
| 19 | Influence of interac- tions on water and aroma permeabilities of iota-carrageenan-oleic acid- beeswax films used for flavour encapsulation显示文摘 | FABRA M J HAMBLETON A TALENTS P | 2009 | Carbohydrate Polymers2009，76，2： | 1 |
| 20 | Oxidized proteins in Alzheimer's disease显示文摘 | Marshall PL Talent JM | 2000 | Biochem Biophys Res Commun2000，275，： | 1 |
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