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| 1 | 乙型肝炎病毒慢性感染者血清中不同类型病毒转录体的检测及其意义显示文摘目的:建立针对乙型肝炎病毒(HBV)全长型(fRNA)和顿挫型转录体(trRNA)的血清学检测方法,并探讨其临床应用价值.方法:自患者血清中提取病毒核酸,经PCR及PRT-PCR进行扩增,琼脂糖电泳显示产物,Southern印迹验证反应的特异性.取代表性产物克隆,测序.结果:在HBV慢性携带者的血清中检测到了在上述不同poly(A)位点成熟的病毒RNA.血清中fRNA的检出与e抗原阳性和较强的病毒DNA信号相对应,与转氨酶活性呈正相关,这一血清学指标反映了病毒复制;而trRNA的检出与e抗原阳性和转氨酶活性无关,不象fRNA那样依赖于血清中病毒DNA的量.二者检出率随年龄有不同变化,前者随年龄增加而进行性减低乃至转阴;而后者在10-20岁期间检出率升至80%,以后维持在较高水平.即使在某些表面抗原阴性血清中,也能检测到trRNA和不在上述两个位点成熟的病毒RNA.这些转录体在某些隐源性肝硬变和丙型肝炎患者血清中也存在.结论:病毒转录体的血清学检测有助于确定目前尚不认识的HBV感染期,可用来更准确地区分复制期和非复制期以及检出隐匿性HBV感染. | 苏勤 张伟 刘节 王淑芳 Kunio Takegoshi Claus H Schrder | 2003 | 世界华人消化杂志2003，11，2： | 16 |
| 2 | Transnasal endoscopic retrograde chalangiopancreatography using an ultrathin endoscope: A prospective comparison with a routine oral procedure显示文摘AIM: To investigate if transnasal endoscopic retrograde cholangiopancreatography (n-ERCP) using an ultrathin forward-viewing scope may overcome the disadvantages of conventional oral ERCP (o-ERCP) related to the large- caliber side-viewing duodenoscope. METHODS: The study involved 50 patients in whom 25 cases each were assigned to the o-ERCP and n-ERCP groups. We compared the requirements of esophagogastroduodenoscopy (EGD) prior to ERCP, rates and times required for successful cannulation into the pancreatobiliary ducts, incidence of post-procedure hyperamylasemia, cardiovascular parameters during the procedure, the dose of a sedative drug, and successful rates of endoscopic naso-biliary drainage (ENBD). RESULTS: Screening gastrointestinal observations were easily performed by the forward-viewing scope and thus no prior EGD was required in the n-ERCP group. There was no significant difference in the rates or times for cannulation, or incidence of hyperamylasemia between the groups. However, the cannulation was relatively difficult in n-ERCP when the scope appeared U-shape under fluoroscopy. Increments of blood pressure and the amount of a sedative drug were significantly lower in the n-ERCP group. ENBD was successfully performed succeeding to the n-ERCP in which mouth-to-nose transfer of the drainage tube was not required. CONCLUSION: n-ERCP is likely a well-tolerable methodwith less cardiovascular stress and no need of prior EGD or mouth-to-nose transfer of the ENBD tube. However, a deliberate application is needed since its performance is difficult in some cases and is not feasible for some endoscopic treatments such as stenting. | Akihiro Mori Noritsugu Ohashi Takako Maruyama Hideharu Tatebe Katsuhisa Sakai Takashi Shibuya Hiroshi Inoue Shoudou Takegoshi Masataka Okuno | 2008 | World Journal of Gastroenterology2008，14，10： | 6 |
| 3 | Hepatocellular carcinoma and type 2 diabetes mellitus: cytokeratin 8/18 expression in hepatocellular carcinoma and glycogen-storing hepatocytes显示文摘Sir,We have reported two patients with hepatocellular carcinoma(HCC)and type 2 diabetes mellitus(T2DM),who showed abundant glycogen in their liver parenchyma but a marked reduction of glycogen content in HCC.[1]It was suggested that the latter was associated with appearance of a Warburg type glycolysis[1]and discussed in some detail.[2] | Kunio Takegoshi Eikichi Okada Qin Su | 2016 | Hepatoma Research2016，2，1： | 2 |
| 4 | Galvanic-evoked myogenic responses in patients with an absence of click-evoked vestibule-collic reflexs显示文摘 | Murofushi T Takegoshi H Ohki M | 2002 | Clinical Neurophysiology2002，113，： | 1 |
| 5 | Glycerol affects vestibular evoked myogenic potentials in Meniere's disease显示文摘 | Murofushi T Matsuzaki M Takegoshi H | 2001 | Auris Nasus Larynx2001，28，： | 1 |
| 6 | High-resolution NMR with resistive and hybrid magnets:Deconvolution using a field-fluctuation signal显示文摘 | Iijima T Takegoshi K Hashi K | 2007 | J Magn Reson2007，184，2： | 1 |
| 7 | Autonomic nervous function in upper gastrointestinal endoscopy: A prospective randomized comparison between transnasal and oral procedures显示文摘 | Akihiro Mori Noritsugu Ohashi Hideharu Tatebe Takako Maruyama Hiroshi Inoue Shoudou Takegoshi Toshiharu Kato Masataka Okuno | 2008 | Journal of Gastroenterology2008，，1： | 1 |
| 8 | On the extension of L2 holomorphic functions显示文摘 | Ohsawa T Takegoshi K | 1987 | Math Z1987，195，2： | 1 |
| 9 | 13C-1H dipolar-assisted rotational resonance in magic-angle spinning NMR显示文摘 | Takegoshi K Nakamura S Terao T | 2001 | Chem Phys Lett2001，344，56： | 1 |
| 10 | Compensation of effect of field instability by reference deconvolution with phase reconstruction显示文摘 | Iijima T Takegoshi K | 2008 | J Magn Reson2008，191，1： | 1 |
| 11 | 13C-13C polarization transfer by resonant interference recoupling under magic-angle spinning in solid-state NMR显示文摘 | Takegoshi K Nakamura S Terao T | 1999 | Chem Phys Lett1999，307，56： | 1 |
| 12 | 13C-1H dipolar-driven 13C-13C recoupling without 13C rf irradiation in nuclear magnetic resonance of rotating solids显示文摘 | Takegoshi K Nakamura S Terao T | 2003 | J Chem Phys2003，118，5： | 1 |
| 13 | Circulating Hepatitis B Virus Nucleic Acidsin Chronic Infection: Represantation of Differently Polyadenylated Viral Transcripts during Progression to Nonreplicative Stages 显示文摘 | Su Q Wang SF Chang TE Breitkeutz R Hennig H Takegoshi K Edler L Schroeder CH | 2001 | Clin Cancer Res2001，7，： | 1 |
| 14 | Coupling between cyclooxygenases and terminal prostanoid synthases显示文摘 | Ueno N Takegoshi Y Kamei D | 2005 | Biochem Biophys Res Commun2005，338，： | 1 |
| 15 | Sex and age differences in the bony nasolaerimal canal: an anatomical study 显示文摘 | Shigeta K Takegoshi H Kikuchi S | 2007 | Arch Ophthalmol2007，125，12： | 1 |
| 16 | Diagnostic value of prolonged latencies in the vestibular-evoked myogenic potential显示文摘 | Murofushi T Shimizu K Takegoshi H | 2001 | Arch Otolaryngol Head Neck Surg2001，127，9： | 1 |
| 17 | Sex and age differences in the bony nasolacrimal canal: an anatomical study 显示文摘 | Shigeta K Takegoshi H Kikuchi S | 2007 | Arch Ophthalmo12007，125，： | 1 |
| 18 | Diagnos-tic value of prolonged latencies in the vestibular evokedmyogenic potential 显示文摘 | Murofushi T Shimizu K Takegoshi H | 2001 | Arch Otolaryngol Head NeckSurg2001，127，9： | 1 |
| 19 | Diagnos-tic value of prolonged latencies in the vestibular evokedmyogenic potential 显示文摘 | Murofushi T Shimizu K Takegoshi H | 2001 | Arch Otolaryngol Head NeckSurg2001，127，9： | 1 |
| 20 | A statistical analysis of epistaxis between outpatients and inpatients 显示文摘 | Hasegawa T Takegoshi H Kikuchi S | 2004 | Nippon Jibiinkoka Gakkai Kaiho2004，107，1： | 1 |
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