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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | 三级高血压单位5100例患者低血钾症与原发性醛固酮增多症的发病率显示文摘常伴有低血钾症的原发性醛固酮增多症(原醛)被认为是一个少见病。广泛筛查高血压患者发现正常血钾的原醛发生率增加。许多研究报道原醛低血钾症的发生率,相反,低血钾症患者中原醛的发生率并不明确。在该回顾性观察研究,研究者探讨了高血压患者中低钾的发生率以及低血钾症合并高血压患者中原醛的发生率。 | 赵狄(译) 刘莉(审校) Burrello J Monticone S Losano I Cavaglià G Buffolo F Tetti M Covella M Rabbia F Veglio F Pasini B Williams TA Mulatero P | 2020 | 中华高血压杂志2020，28，3： | 7 |
| 3 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 4 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 5 | The elephant in uremia:Oxidant stress as a unifying concept of cardiovascular disease in uremia显示文摘 | Jonathan H Stenvinkel P Ikizler TA | 2002 | Kidney Int2002，62，： | 2 |
| 6 | Mandibular invasion by squamous cell carcinoma: A computed tomographic and histological study显示文摘 | Huntley TA Busmanis I Desmond P | 1996 | Br J Oral Maxillofac Surg1996，34，1： | 1 |
| 7 | The significance of natural and synthetic auxins in the control of stomatal movements 显示文摘 | Cox R C Snaith P J Mansfield TA | 1985 | Acta Horticulture1985，171，： | 1 |
| 8 | Trabeculecto- my with mitomycin C in fractory glaucoma associated with non- necrotizing anterior scleritis 显示文摘 | Williams TA Sii F Chaing M Murray PI Shah P | 2009 | Ocal Immunol Inflamm2009，17，5： | 1 |
| 9 | Integrated left small thoracotomy and angioplasty for multivessel coronary artery revascularisation显示文摘 | Angelini GD Wilde P Salerno TA | | 0，，： | 1 |
| 10 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 11 | miRNAs in human cancer显示文摘 | Farazi TA Spitzer JI Morozov P | 2011 | J Pathol2011，223，2： | 1 |
| 12 | miRNAs in human cancer显示文摘 | Farazi TA Spitzer JI Morozov P | 2011 | J Pathol2011，223，2： | 1 |
| 13 | Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma显示文摘 | Christopoulos TA Papageorgakopoulou N Ravazoula P | 2007 | Oncol Rep2007，18，4： | 1 |
| 14 | Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic Haemophitus influenzae airway infection: comparison with noninfected patients with chronic obstructive pulmonary disease显示文摘 | Bresser P Out TA van Alphen L | 2000 | Am J Respir Crit Care Med2000，162，31： | 1 |
| 15 | Amino acid and albumin losses during hemodialysis显示文摘 | Ikizler TA Flakoll P Parker R Hakim R | 1994 | Kidney Int1994，46，： | 1 |
| 16 | Retinopathy is reduced during experimental di- abetes in a mouse model of outer retinal degeneration 显示文摘 | de Gooyer TE Stevenson KA Htmlphries P Simpson DA Gardi- ner TA Stitt AW | 2006 | In- vest Ophthalmol Vis Sci2006，47，12： | 1 |
| 17 | Harvesting and enrichment of HPC mobilized into the peripheral blood of normal donors by GM-CSF or G-CSF:Potential role in allogeneic transplantation显示文摘 | Lane TA Law P Maruyama M | 1995 | Blood1995，85，1： | 1 |
| 18 | miRNAs in human cancer 显示文摘 | Farazi TA Spitzer JI Morozov P | 2011 | J Pathol2011，223，2： | 1 |
| 19 | Equipoise among recanalization strategies显示文摘 | Tomsick TA Khatri P Jovin T | 2010 | Neurology2010，74，13： | 1 |
| 20 | Intraoperative touch imprint cytology of sentinel lymph nodes in breast cancer:experience at a tertiary care center in Mexico显示文摘 | Pérez-Sánchez VM Vela-Chávez TA Villarreal-Colin P | 2010 | Med Oncol2010，27，2： | 1 |
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