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| 1 | Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients显示文摘AIM: To investigate the association of the functional monocyte chemotactic protein-1(MCP-1) promoter polymorphism(A-2518G) with spontaneous bacterial peritonitis(SBP).METHODS: Fifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group Ⅰ included 25 patients with SBP and group Ⅱ included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin(IL)-10 levels in both blood and ascitic fluid. RESULTS: A significant MCP-1 gene polymorphism was detected in groups Ⅰ and Ⅱ(P = 0.001 and 0.02 respectively). Group Ⅰ was associated with a significantly higher frequency of AG genotype [control 8(40%) vs SBP 19(76.0%), P < 0.001], and group Ⅱ was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1(5%) vs cirrhotic 16(64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups(Ⅰ and Ⅱ) [control 10(25%) vs SBP 27(54%), P < 0.001 and vs cirrhotic 37(74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group Ⅰ than in group Ⅱ. Group Ⅰ showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy. CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications. | Maysa Kamal Salama Dina Sabry Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | Upper gastrointestinal heamorrhage associated with low-dose aspirin and anti-thrombotic drugs-a 6 year analysis and comparison with non-steroidal anti- inflammatory drugs显示文摘 | Taha AS Angerson WJ Knill RP | 2005 | Aliment Pharmacol Ther2005，22，4： | 1 |
| 3 | Intravasular administration of polymerized gelatin versus isotonic saline for prevention ofspinalinduced hypotension显示文摘 | Baraka AS Taha SK Ghabach MB | 1994 | Anesth Analg1994，78，2： | 1 |
| 4 | Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low - dose aspirin and nonsteroidal anti - inflammatory drugs 显示文摘 | Taha AS Angerson WJ Prasad R | 2008 | Aliment Pharmacol Ther2008，28，7： | 1 |
| 5 | Oxygenation using tidal volume breathing after maximal exhalation显示文摘 | Baraka AS Taha SK El-Khatib MF | 2003 | Anesth Analg2003，97，5： | 1 |
| 6 | Low frequency jet ventilation for stent insertion in a patient with tracheal stenosis显示文摘 | Baraka AS Siddik SS Taha SK | 2001 | Cart J Anaesth2001，48，7： | 1 |
| 7 | lntravascular adiministration of polymerized gelatin versus istonic saline for prevention of spinal- induced hypotension显示文摘 | Baraka AS Taha SK Ghabach MB | 1994 | Anesth Analg1994，78，2： | 1 |
| 8 | Famotidine for the prevention of peptic ulcers and cesophagitis in patients taking low-dose aspirin(FAMOUS) : a phase m, randomised, double-blind, placebo-controlled trial 显示文摘 | Taha AS McCloskey C Prasad R | 2009 | Lancet2009，374，： | 1 |
| 9 | Intravascular adiministration of potymerized gelatin versus isotonic saline for prevention of spinal-induced hypotension显示文摘 | Taha SK Ghabach MB | 1994 | Anesth Analg1994，78，： | 1 |
| 10 | Intravascular administration of potymerized gelatin versus isotonic saline for prevention of spinal - induced hypotension 显示文摘 | Baraka AS Taha SK Ghabach MB | 1994 | Anesth Analg1994，78，： | 1 |
| 11 | Clinical trial: the inci- dence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs 显示文摘 | Taha AS Angerson WJ Prasad R | 2008 | Aliment Pharmacol Ther2008，28，7： | 1 |
| 12 | Supplementation of pre-oxygenation in morbidly obese patients using nasopharyngeal oxygen insufflation显示文摘 | Baraka AS Taha SK Siddik-Sayyid SM | 2007 | Anaesthesia2007，62，： | 1 |
| 13 | Oesophagitis and bile reflux gastritis-clinical and histological assessments显示文摘 | Taha AS Balsitis M Angerson WJ | 2003 | Dig Liver Dis2003，35，10： | 1 |
| 14 | Clinical trial:the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs显示文摘 | Taha AS Angerson WJ Prasad R | 2008 | Alimem Pharmacol Ther2008，28，： | 1 |
| 15 | Gastric mucosal prostaglandin synthesis in the presenee of campy- lobacter pylori in patients with gastric ulcers and non-ulcer dyspepsia 显示文摘 | Taha AS Boothman P Holland P | 1990 | Am J Gastroenterol1990，85，1： | 1 |
| 16 | Reflux and Barrett's oesophagus after gastric surgery:long - term follow - up and implications for theroles of gastric acid and bile in oesophagitis显示文摘 | Taha AS Angerson WJ Morran CG | 2003 | Aliment Pharmacol Ther2003，17，3： | 1 |
| 17 | Intravascular administration of polymerized gelatin versus isotonic saline for prevention of spinal-induced hypotension1显示文摘 | Baraka AS Taha SK Ghabach MB | 1994 | Anesth Analg1994，78，： | 1 |
| 18 | Transient atrioventricular block after release of aortic cross-clamp显示文摘 | Baraka AS Taha SK Yazbeck VK | 1995 | Anesth Analg1995，80，1： | 1 |
| 19 | Helicobacter pylori and non-steroidal anti-inflarnmatory drugs:uncomfortable parters in peptic ulcer disease显示文摘 | Taha AS Russell RI | 1993 | Gut1993，34，： | 1 |
| 20 | Russell RI The interaction between Helicobacter pylori culture fillrate and indomethaein effects on the integrity of human gastric antral mucosa and its prostagladins E2 production in vitro显示文摘 | Taha AS Kelly RW Gemmell CG | 1990 | Aliment Phannacol Ther1990，4，3： | 1 |
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