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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | The Effects of Nozzle Geometry on Waterjet Breakup at High Reynolds Numbers显示文摘 | Tafreshi H V Pourdeyhimi B | | 0，，4： | 1 |
| 3 | Proposing in- dicators for the development of nursing care quality in Iran 显示文摘 | Pazargadi M Tafreshi MZ Abedsaeedi Z | 2008 | Int Nurs Rev2008，55，4： | 1 |
| 4 | Endogenous nerve growth factor and neurotrophin-3 act simultaneously to ensure the survival of postnatal sympathetic neurons in vivo 显示文摘 | Tafreshi A P Zhou X F Rush R A | 1998 | Neuroscience1998，83，2： | 1 |
| 5 | Complications of beta-thalassemia intermedia in Iran during 1996-2010(single-center study)显示文摘 | Rafsanjani KA Mafi N Tafreshi RI | 2011 | Pediatr Hematol Oncol2011，28，： | 1 |
| 6 | Molecular and functional im?aging of breast cancer显示文摘 | Tafreshi N K Kumar V Morse D L et at | 2010 | Cancer control2010，17，3： | 1 |
| 7 | Stress analysis of drillstring threaded connections using the finite element method显示文摘 | Tafreshi A Dover WD | 1993 | Int J Fatigue1993，15，5： | 1 |
| 8 | A case study of simulating submicron aerosol filtration via lightweight spun-bonded filter media显示文摘 | WANG Q MA ZE B VAHEDI TAFRESHI H POURDEYHIMI B | 2006 | Chemical Engineering Science2006，61，15： | 1 |
| 9 | Stress analysis of three-dimensional contact problems using the boundary element method 显示文摘 | Segond D Tafreshi A | 1998 | Engineering analysis with boundary elements1998，22，3： | 1 |
| 10 | A realistic approach for modeling permeability of fibrous media: 3-D imaging coupled with CFD simulation 显示文摘 | Jaganathan S Vahedi Tafreshi H Pourdeyhimi B | 2008 | Chemical Engineering Science2008，63，1： | 1 |
| 11 | A simulation of unsteady-state filtration via nanofiber media at reduced operating pressures显示文摘 | Maze B Vahedi Tafreshi H Wang Q | 2007 | Journal of Aerosol Science2007，38，5： | 1 |
| 12 | On the importance of fiberscross-sectional shape for air filters operating in the slip flow regime显示文摘 | HOSSEINI S A TAFRESHI H V | 2011 | Powder Technology2011，212，3： | 1 |
| 13 | Efficient modelling of delamination buckling in composite cylindrical shells under axial compression显示文摘 | Tafreshi Azam | 2004 | Composite Structures2004，64，34： | 1 |
| 14 | Laboratory tests of small-diameter HDPE pipes buried in reinforced sand under repeated-load显示文摘 | Moghaddas Tafreshi S N Khalaj O | 2008 | Geotextiles Geomembranes2008，26，2： | 1 |
| 15 | Buckling and post-buckling analysis of composite cylindrical shells with cutouts subjected to internal pressure and axial compression loads 显示文摘 | TAFRESHI A | 2002 | International Journal of Pressure Vessels and Piping2002，79，： | 1 |
| 16 | Supe- rhydrophobic surfaces: From the lotus to the submarine 显示文摘 | SAMAHA M A TAFRESHI H V GAD-EL-HAK M | 2012 | Comptes Rendus Mecanique2012，340，12： | 1 |
| 17 | A Study on Flow Through Hydroentangling Nozzles and Their Degradation 显示文摘 | Anantharamaiah N Vahedi Tafreshi N Pourdeyhimi B | 2006 | Chem Eng Sei2006，61，14： | 1 |
| 18 | A review of the investi gational antiarrhythmic agent dronedarone显示文摘 | TAFRESHI M J ROWLES J | 2007 | J Card iovasc Pharmacol Ther2007，12，： | 1 |
| 19 | Instability of delaminated composite cylindrical shells under combined axial compression and bending显示文摘 | Azam Tafreshi | 2008 | Composite Structures2008，82，： | 1 |
| 20 | Stress analysis of drill string threaded connections using finite element method 显示文摘 | Tafreshi A Dover W D | 1993 | Fatigue1993，15，5： | 1 |
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