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| 1 | Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice显示文摘The imbalance between β-amyloid(Aβ) generation and clearance plays a fundamental role in the pathogenesis of Alzheimer 's disease(AD). The sporadic form of AD is characterized by an overall impairment in Aβ clearance. Immunotherapy targeting Aβ clearance is believed to be a promising approach and is under active clinical investigation. Autophagy is a conserved pathway for degrading abnormal protein aggregates and is crucial for Aβ clearance. We previously reported that oral vaccination with a recombinant AAV/Aβ vaccine increased the clearance of Aβ from the brain and improved cognitive ability in AD animal models, while the underlying mechanisms were not well understood. In this study, we first demonstrated that oral vaccination with rAAV/Aβ decreased the p62 level and up-regulated the LC3BII/LC3B-I ratio in APP/PS1 mouse brain, suggesting enhanced autophagy. Further, inhibition of the Akt/m TOR pathway may account for autophagy enhancement. We also found increased anti-Aβ antibodies in the sera of APP/PS1 mice with oralvaccination, accompanied by elevation of complement factors C1 q and C3 levels in the brain. Our results indicate that autophagy is closely involved in oral vaccination-induced Aβ clearance, and modulating the autophagy pathway may be an important strategy for AD prevention and intervention. | He-Cheng Wang Tao Zhang Bolati Kuerban Ying-Lan Jin Weidong Le Hideo Hara Dong-Sheng Fan Yan-Jiang Wang Takeshi Tabira De-Hua Chui | 2015 | Neuroscience Bulletin2015，31，4： | 8 |
| 2 | Molecular basis of Alzheimer's disease:from amyloid hypothesis to treatment in the foreseeable future显示文摘 | Tabira T | 2004 | G eriatr Gerontol Inter2004，4，1： | 1 |
| 3 | Recurrent nerve nodal involvement is associated with cervical nodal metastasis in thoracic esophageal carcinoma显示文摘 | Tabira Y Yasunaga M Tanaka M | 2000 | J Am Coll Surg2000，191，3： | 1 |
| 4 | width of a gastric tube has no impact on outcome a er esophagectomy显示文摘 | Tabira Y Sakaguchi T Kuhara H | 2004 | Am J Surg2004，187，3： | 1 |
| 5 | Assignment of a familial Alzheimer's disease locus between D14S289 and D14S53显示文摘 | Takahashi K Tabira T | 1994 | Lancet1994，344，： | 1 |
| 6 | Current trend of immunotherapy for Alzheimer's disease显示文摘 | Matsumoto S E Tabira T | 2011 | Nihon Rinsho2011，69，： | 1 |
| 7 | Significance of three--field lymphadenectomy for carcinoma of the thoracic esophagus based on depth of tumor infiltration, lymph nodal involvement and survival rate显示文摘 | Tabira Y Kitamura N Yoshioka M | 1999 | J Cardiovasc Surg1999，40，5： | 1 |
| 8 | Structural Re- quirements of Para-alkylphenols to Bind to Estrogen Receptor显示文摘 | TABIRA Y NAKAI M ASAI D | 1999 | European Journal of Biochemistry1999，262，1： | 1 |
| 9 | The width of a gastric tube has no impact on outcome after esophagectomy 显示文摘 | Tabira Y Sakaguchi T Kuhara H | 2004 | Am J Surg2004，187，3： | 1 |
| 10 | Effect of administered human growth hormone on protein metabolism in septic rats 显示文摘 | Okamura K Okuma T Tabira Y | 1989 | JPEN J Parenter Enteral Nutr1989，13，5： | 1 |
| 11 | Isolation of human delta-catenin and its binding specificity with presenilin 1显示文摘 | Tanahashi H Tabira T | | 0，，03： | 1 |
| 12 | Accelerated growth signals and low tumor-infiltrating lymphocyte levels predict poor outcome in T《,4 esophageal squamous cell carcinoma显示文摘 | Yasunaga M Tabira Y Nakano K | 2000 | Am Thorac Surg2000，70，5： | 1 |
| 13 | Recurrent nerve nodal involvement is associated with cervical nodal metastasis in thoracic esophageal carcinoma显示文摘 | Tabira Y Yasunaga M Tanaka M | 2000 | J Am Coll Surg2000，191，3： | 1 |
| 14 | Evaluation of oxygen consumption and resting energy expenditure in critically ill patients with systemic inflammatory response syndrome显示文摘 | Moriyama S Okamoto K Tabira Y | 1999 | Crit Care Medl1999，27，10： | 1 |
| 15 | Recurrent nerve nodal involvement is associated with cervical nodal metastasis in thoracic esophageal carcinoma显示文摘 | Tabira Y Yasunaga M Tanaka M | 2000 | J Am Coll Surg2000，191，3： | 1 |
| 16 | The width of a gastric tube has no impact on outcome after esophagectomy显示文摘 | YOICHI TABIRA TOMONORI SAKAGUCHI HIROSHI KU HARA | 2004 | Am J Surg2004，187，： | 1 |
| 17 | Genomic organization of the human X11L2 gene (APBA3),a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein显示文摘 | Tanahashi H Tabira T | 1999 | Neuroreport1999，10，12： | 1 |
| 18 | Indications for EMR/ESD in cases of early gastric cancer: relationship between histological type, depth of wall invasion, and lymph node metastasis显示文摘 | Shinji Ishikawa Akihiko Togashi Mituhiro Inoue Shinobu Honda Fumiaki Nozawa Eiichirou Toyama Nobutomo Miyanari Youichi Tabira Hideo Baba | 2007 | Gastric Cancer2007，，1： | 1 |
| 19 | X11L2,a new member of the X11 protein family,interacts with Alzheimer's β-amyloid precursor protein显示文摘 | Tanahashi H Tabira T | 1999 | Biochem Biophys Res Commun1999，255，3： | 1 |
| 20 | Recurrent nerve nodal involvement is associated with cervical nodal metastasis in thoracic esophageal carcinoma 1 1 No competing interests declared.显示文摘 | Yoichi Tabira Masahiro Yasunaga Makoto Tanaka Kan-yu Nakano Tomonori Sakaguchi Nobuhide Nagamoto Sukeaki Ogi Nobuo Kitamura | 2000 | Journal of the American College of Surgeons2000，，3： | 1 |
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