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| 1 | 口腔精准医学:现状与挑战显示文摘精准医学是人类基因组计划的延续,是医学发展的必然产物,是一种考虑人群基因、环境及生活方式个体差异的促进健康和治疗疾病的新兴医学模式。本文首次提出口腔精准医学的概念,以口腔典型疾病为例,结合近期的研究成果与学者观点,阐述口腔精准医学对口腔学科发展的指导意义及实现口腔精准医学将面对的机遇与挑战。 | 徐欣 郑欣 郑黎薇 程磊 周学东 | 2015 | 华西口腔医学杂志2015，33，3： | 16 |
| 2 | Role of saliva proteinase 3 in dental caries显示文摘Salivary analysis can be used to assess the severity of caries. Of the known salivary proteins, a paucity of information exists concerning the role of proteinase 3(PR3), a serine protease of the chymotrypsin family, in dental caries. Whole, unstimulated saliva was collected from children with varying degrees of active caries and tested using a Human Protease Array Kit and an enzyme-linked immunosorbent assay.A significantly decreased concentration of salivary PR3 was noted with increasing severity of dental caries(P,0.01); a positive correlation(r50.87; P,0.01; Pearson's correlation analysis) was also observed between salivary p H and PR3 concentration. In an antibacterial test,a PR3 concentration of 250 ng?m L21 or higher significantly inhibited Streptococcus mutans UA159 growth after 12 h of incubation(P,0.05). These studies indicate that PR3 is a salivary factor associated with the severity of dental caries, as suggested by the negative relationship between salivary PR3 concentration and the severity of caries as well as the susceptibility of S. mutans to PR3. | Teng-Yu Yang Wen-Jie Zhou Yue Du Song-Tao Wu Wen-Wen Yuan Yu Yu Lin Su Yang Luo Jie-Hua Zhang Wan-Lu Lu Xiao-Qian Wang Jiao Chen Yun Feng Xue-Dong Zhou Ping Zhang | 2015 | International Journal of Oral Science2015，7，3： | 2 |
| 3 | A magnetic nanoparticles-based method for DNA extraction from the saliva of stroke patients显示文摘C677T polymorphism in the methylenetetrahydrofolate reductase(MTHFR) gene is a risk factor for stroke,suggesting that widespread detection could help to prevent stroke.DNA from 70 stroke patients and 70 healthy controls was extracted from saliva using a magnetic nanoparticles-based method and from blood using conventional methods.Real-time PCR results revealed that the C677T polymorphism was genotyped by PCR using DNA extracted from both saliva and blood samples.The genotype results were confirmed by gene sequencing,and results for saliva and blood samples were consistent.The mutation TT genotype frequency was significantly higher in the stroke group than in controls.Homocysteine levels were significantly higher than controls in both TT genotype groups.Therefore,this noninvasive magnetic nanoparticles-based method using saliva samples could be used to screen for the MTHFR C677T polymorphism in target populations. | Li Yi Ying Huang Ting Wu Jun Wu | 2013 | Neural Regeneration Research2013，8，32： | 1 |
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