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| 1 | Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy显示文摘Acute appendicitis(AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy(LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended resection in patients with an appendiceal mass. Nonoperative management of AA may be tolerated only in children. Postoperative complications increase according to the patient's factors, and temporal avoidance of emergent general anesthesia may be beneficial for high-risk patients. The surgeon's skill and cooperation of the hospital are important for successful LA. Delaying appendectomy for less than 24 h from diagnosis is safe. Additionally, a semi-elective manner(i.e., LA within 24 h after onset of symptoms) may be paradoxically acceptable, according to the factors of the patient, physician, and institution. Prompt LA is mandatory for AA. Fortunately, the Japanese government uses a universal health insurance system, which covers LA. | tomohide hori takafumi machimoto yoshio kadokawa toshiyuki hata tatsuo ito shigeru kato daiki yasukawa yuki aisu yusuke kimura maho sasaki yuichi takamatsu taku kitano shigeo hisamori tsunehiro yoshimura | 2017 | World Journal of Gastroenterology2017，23，32： | 18 |
| 2 | 高产DHA海洋真菌Thraustochytrium sp.N4-103脂肪酸组成及其18SrRNA基因的克隆与序列分析显示文摘采用松花粉垂钓法分离到一株docosahexaenoicacid(DHA)高产菌Thraustochytriumsp.N4-103.该菌株细胞油脂的脂肪酸组型为47.3%DHA,11.6%C22∶5(n-6),9.4%C20∶5(n-3),9.1%C20∶4(n-6)和22.6%C16∶0;单细胞油脂由42.6%极性脂肪,45.3.%中性脂肪和12.1%糖脂组成.细胞生长与DHA合成的最佳条件:碳源为葡萄糖,氮源为酵母膏,温度为25℃.利用PCR技术分离得到N4-103菌株18SrRNA基因并进行了克隆测序,序列含有Thraustochytrids的特征插入片段.依据18SrRNA基因序列所构建的遗传进化树表明该菌是一株与Thraustochytriumsp.KK17-3具有紧密亲源关系的未报道的破囊壶菌. | 黄建忠 江贤章 刘丽霞 吴松刚 Tsunehiro AKI | 2005 | 福建师范大学学报(自然科学版)2005，21，1： | 3 |
| 3 | Protocol for laparoscopic cholecystectomy: Is it rocket science?显示文摘Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical considerations.Finally, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies. | Tomohide Hori Fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 4 | Saving two in a billion : a case study to quantify the trade effect of european food safety standards on african exports, development research group (DECRG)显示文摘 | Tsunehiro Otsuki John Wilson S Mirvat Sewadeh | 2001 | Food Policy2001，26，： | 1 |
| 5 | ,2001 ,Saving two in a billion: quantifying the trade effect of European food safety standards on African exports 显示文摘 | Otsuki tsunehiro John S Wilson Mirvat Sewadeh | 2001 | Food Policy2001，26，5： | 1 |
| 6 | Gastric carcinogenesis and the cancer stem cell hypothesis显示文摘 | Yoshiro Saikawa Kazumasa Fukuda Tsunehiro Takahashi Rieko Nakamura Hiroya Takeuchi Yuko Kitagawa | 2010 | Gastric Cancer2010，，1： | 1 |
| 7 | Selective photo-oxidation of neat cyclohexane in the liquid phase over V2O5/Al2O3显示文摘 | KENTARO T TSUNEHIRO T MASAYA K | 2004 | J Mol Cat A:Chem2004，208，12： | 1 |
| 8 | Macrophage stimulation activity of the polysaccharide fraction from a marine alga (Porphyra yezoensis ) : structure - function relationships and improved solubilty 显示文摘 | Yashizawa Y Ametani A Tsunehiro J | 1995 | Biosci Biotech Biochem1995，59，10： | 1 |
| 9 | 显示文摘 | Teramura Kentaro Tanaka Tsunehiro Yamamoto Takashi | 2001 | Journal of Molecular Catalysis A:Chemical2001，165，： | 1 |
| 10 | What Price Precaution? European Harrnonisation of Aflatoxin Regulations and African Groundnuts Exports显示文摘 | OTSUKI TSUNEHIRO JOHN S WILSON | 2001 | European Review of Agricultural Economic2001，，： | 1 |
| 11 | 显示文摘 | Teramura Kentaro Tanaka Tsunehiro Hosokawa Tomohiro | 2004 | Catalysis Today2004，96，： | 1 |
| 12 | Macrophage stimulation activity of the polysaccharide fraction from a marine alga (Porphyra yezoensis) : structure- function relationships and improved solubility显示文摘 | Yashizawa Y Ametani A Tsunehiro J | 1995 | Biosci Biotech Biochem1995，59，10： | 1 |
| 13 | Cytochrome P450 expression (CYP) in non-small cell lung cancer显示文摘 | Tsunehiro Oyama Kenji Sugio Hidetaka Uramoto | 2007 | Frontiers in Bioscience2007，12，： | 1 |
| 14 | Saving two in a billion: quantifying the trade effect of European food safety standards on African exports 显示文摘 | TSUNEHIRO OSTUKI JOHN S WILSON MIRVAT SEWADEH | 2001 | Food Policy2001，26，5： | 1 |
| 15 | Macro-phage Stimulation Activity of the Polysaccharide Frac-tion from a Marine Alga (Porphyra yezoensis) :Struc-ture-Function Relationships and Improved Solubility 显示文摘 | Yoshizawa Y Ametani A Tsunehiro J | 1995 | Biosci Biotechnol Biochem1995，59，10： | 1 |
| 16 | To spray or not to spray: pesticides, banana exports, and food safety显示文摘 | John S. Wilson Tsunehiro Otsuki | 2004 | Food Policy2004，，： | 1 |
| 17 | Simple and sensitiveenzyme-linked immunosorbent assay for ivermectin显示文摘 | Yoshinori M Hideaki T Tsunehiro K | 1996 | Am J TropMed Hyg1996，54，： | 1 |
| 18 | Saving two in a billion:显示文摘 | Tsunehiro Otsuki John S. Wilson Mirvat Sewadeh | 2001 | Food Policy2001，，： | 1 |
| 19 | Macrophage stimulation activity of polysaccharide fractions from marine alga(Porphyra yezoensis):structure-function relationships and improved solubility显示文摘 | Ametani A Tsunehiro J | 1995 | Biosci Biotech Biochem1995，59，： | 1 |
| 20 | Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease:A case report显示文摘BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(H.pylori)infection and an elevated risk of carcinogenesis.Cases of early-stage gastric cancer developed in H.pylori-negative Ménétrier’s disease are extremely rare.We report a case of early gastric cancer in H.pylori-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected anemia.Contrast-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant rugae.Blood tests showed hypoproteinemia and were negative for serum H.pylori immunoglobulin G antibodies.The 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the stomach.UGI endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s disease.En bloc resection with ESD was performed for diagnosis and treatment.Histology of ESD showed well-differentiated tubular adenocarcinoma.The cancer was confined to the mucosa,and complete curative resection was achieved.Foveolar hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s disease.Three years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric rugae.CONCLUSION Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and H.pylori-negative Ménétrier’s disease. | Koh Fukushi Kenichi Goda Hitoshi Kino Masayuki Kondo Mimari Kanazawa Ken Kashima Akira Kanamori Keiichiro Abe Tsunehiro Suzuki Keiichi Tominaga Hidetsugu Yamagishi Atsushi Irisawa | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
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