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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Comparison of two total knee prostheses on the incidence of patella clunk syndrome 显示文摘 | Ip D Wu WC Tsang WL | 2002 | Int Orthop2002，26，1： | 1 |
| 3 | Conventional muscle-reflection approach versus mini-incision muscle-splitting approach in dynamic hip screw fixation显示文摘 | Leung WY Tsang WL | 2008 | Journal of Orthopaedic Surgery2008，16，2： | 1 |
| 4 | A double-blind, pro-spective, randomised, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertroehanterie fractures 显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
| 5 | Medial humeral epicondylar fracture in children and adolescents显示文摘 | Ip D Tsang WL | 2007 | J Orthop Surg (Hong Kong)2007，15，2： | 1 |
| 6 | A double-blind, pro- spective,randomised, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric {ractures显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
| 7 | Casting versus percutaneous pinning for extra-articular fractures of the distal radius in an elderly Chinese population:a prospective randomised controlled trial显示文摘 | WONG TC CHIU Y TSANG WL | 2010 | J Hand Surg Eur Vol2010，35，3： | 1 |
| 8 | Conventional muscle-reflection approach versus mini-incision muscle-splitting approach in dynamic hip screw fixation显示文摘 | Leung WY Tsang WL | 2008 | J Orthop Surg( Hong Kong)2008，16，2： | 1 |
| 9 | Mycobacterium farcinogenes infection after total hip arthroplasty显示文摘 | Wong TC Chan WF Tsang WL | | 0，，05： | 1 |
| 10 | Conventional muscle-reflection approach versus mini-incision muscle-splitting approach in dynamic hip screw fixation显示文摘 | Leung WY Tsang WL | 2008 | Journal of orthopaedic surgery (Hong Kong)2008，，02： | 1 |
| 11 | Medial humeral epicondylar fracture in chidren and adolescents显示文摘 | Ip D Tsang WL | 2007 | Journal of Orthopaedic Surgery2007，15，： | 1 |
| 12 | Auto-tunning of Output Predictiv PI Controller显示文摘 | WL Lo A BRad K M Tsang | 1993 | ISA Transaction1993，38，1： | 1 |
| 13 | A double-blind, prospective, randomized, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric fractures显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
| 14 | A double-blind,prospective,randomised,controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric fractures显示文摘 | Wong TC Chiu Y Tsang WL | | 0，，04： | 1 |
| 15 | Conventional muscle-reflection approach versus mini-incision muscle-splitting approach in dynamic hip screw fixation 显示文摘 | Leung WY Tsang WL | 2008 | J Orthop Surg( Hong Kong)2008，16，2： | 1 |
| 16 | A double-blind,prospective, randomized, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric frac- tures显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
| 17 | Comparison of two total knee prostheses on the incidence of patella clunk syndrome显示文摘 | Ip D Wu WC Tsang WL | 2002 | Int Orthop2002，26，1： | 1 |
| 18 | Mycobacterium farcinogenes infection after total hip arthroplasty 显示文摘 | Wong TC Chan WF Tsang WL et aI | 2005 | 1 Arthroplasty2005，20，5： | 1 |
| 19 | A double-blind,prospective,randomised,controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric fractures显示文摘 | Wong TC Chiu Y Tsang WL | | 0，，04： | 1 |
| 20 | A double-blind, pro- spective, randomised, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric fractures显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
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