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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Corrosion of selected nonoxide ceramics in liquid steel显示文摘 | Trigg M B Ellson D B Sinclair W | 1988 | Br Ceram Trans1988，87，： | 1 |
| 3 | Incorporatin of radioactive precur-sors into DNA and RNA of Plasmodium knowlesi in vitro显示文摘 | Gutteridge W E Trigg P I | | 0，，01： | 1 |
| 4 | Repetitive transcranial magnetic stimulation of motor cortex after stroke: a focused review 显示文摘 | Corti M Patten C Triggs W | 2012 | Am J Phys Med Rehabil2012，91，3： | 1 |
| 5 | Repetitive Transcranial Magnetic Stimulation of Motor Cortex after Stroke: A Focused Review显示文摘 | Corti M Patten C Triggs W | 2012 | Am J Phys Med Rehabil2012，91，3： | 1 |
| 6 | Reliability of tran- scranial magnetic stimulation for mapping swallowing musculature in the human motor cortex 显示文摘 | Plowman-Prine EK Triggs W J Malcolm MP | 2008 | Clinical Neurophysiology2008，119，10： | 1 |
| 7 | Sustained testicular atrophy in bulls actively immunized against GnRH: potential to control carcase characteristics 显示文摘 | DOeehio M J Aspden W J Trigg T E | 2001 | Anim Reprod Sci2001，66，12： | 1 |
| 8 | The role of iron-induced hipp- ocampal peroxidation in acute epileptogenesis 显示文摘 | Willmore LJ Triggs W J Gray JD | 1986 | Brain Res1986，382，11： | 1 |
| 9 | Repetitive transcranial magnet-ic stimulation of motor cortex after stroke: a focused review显示文摘 | CORTI M PATTEN C TRIGGS W | 2012 | Am J Phys Med Rehabil2012，91，： | 1 |
| 10 | Repetitive transcranial magnetic stimulation of mo- tor after stroke: a focused review 显示文摘 | Corti M Triggs W | 2012 | Am J Phys Med Rehabil2012，91，3： | 1 |
| 11 | Kaprekar's Routine with Five-Digit Integers显示文摘 | Trigg C W | 1972 | Math Mag1972，45，3： | 1 |
| 12 | Repetitive transcranial magnetic stimulation of motor cortex after stroke: a focused review显示文摘 | Corti M Patten C Triggs W | 2012 | Am JPhysMedRehabil2012，91，3： | 1 |
| 13 | Repetitive transcranial mag- netic stimulation of motor cortex after stroke: a focused re- view显示文摘 | Corti M Patten C Triggs W | 2012 | Am J Phys Med Rehahil2012，91，3： | 1 |
| 14 | Proximal myotonic myopathy: clinical, neuropathologic, and molecular genetic features 显示文摘 | Eisenschenk S Triggs W J Pearl GS | 2001 | Ann Clin Lab Sci2001，31，： | 1 |
| 15 | The effect of cordycepin on malaria parasites显示文摘 | TRIGG P GUTERIDGE W E WILLIAMSON J | 1971 | Trans R Soc Trop Med Hyg1971，65，： | 1 |
| 16 | Corrosion of selected nonoxide ceramics in liquid steel 显示文摘 | Ellson D B Sinclair W | 1988 | Br Ceram Trans1988，87，： | 1 |
| 17 | Repetitive transcranial magnetic stimulation of motor cortex after stroke:a focused review显示文摘 | Corti M Patten C Triggs W | 2012 | Am J Phys Med Rehabil2012，91，： | 1 |
| 18 | The effect of cordycepin on malaria parasites显示文摘 | TRIGG P GUTTERIDGE W E WILLAMSON J | 1971 | Trans R Soc Trop Med Hyg1971，65，： | 1 |
| 19 | ExponentialSmoothing with an Adaptive Response Rate 显示文摘 | Trigg D W Leach A G | 1967 | Operation Research1967，18，1： | 1 |
| 20 | The effect of cordycepin on malaria parasites显示文摘 | TRIGG P GUTTERIDGE W E WILLAMSON J | 1971 | Trans R Soc Trop Med Hyg1971，65，： | 1 |
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