|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes显示文摘The hepatitis C virus(HCV) is one of the most common causes of chronic liver disease and the leading indication for liver transplantation worldwide. Every aspect of the HCV life cycle is closely tied to human lipid metabolism. The virus circulates as a lipid-rich particle, utilizing lipoprotein cell receptors to gain entry into the hepatocyte. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation and circulating hypocholesterolemia. Patients with chronic hepatitis C(CHC) are at increased risk of hepatic steatosis, fibrosis, and cardiovascular disease including accelerated atherosclerosis. HMG Co A Reductase inhibitors, or statins, have been shown to play an important role in the modulation of hepatic steatosis and fibrosis, and recent attention has focused upon their potential therapeutic role in CHC. This article reviews the hepatitis C viral life cycle as it impacts host lipoproteins and lipid metabolism. It then describes the pathogenesis of HCV-related hepatic steatosis, hypocholesterolemia and atherosclerosis, and finally describes the promising anti-viral and anti-fibrotic effects of statins, for the treatment of CHC. | Tracey G Simon Adeel A Butt | 2015 | World Journal of Gastroenterology2015，21，27： | 5 |
| 2 | Application of ellipticalFourier analysis of otolith form as a tool for stock identification显示文摘 | Tracey S R Lyle J M Duhamel G | 2006 | Fish Res2006，77，： | 1 |
| 3 | Immune and inflammatory mechanisms in neuropathie pain显示文摘 | Moalem G Tracey DJ | 2006 | Brain Res Rev2006，51，2： | 1 |
| 4 | Immune and inflammatory mechanisms inneuropathic pain显示文摘 | Moalem G Tracey DJ | 2006 | Brain Res Rev2006，51，2： | 1 |
| 5 | Immune and inflammatory mechanisms in neuropathic pain显示文摘 | Moalem G Tracey DJ | 2006 | Brain Res Rev2006，51，2： | 1 |
| 6 | Anti -cachectin/TNF monoclonal antibodies septic shock during lethal bacteraemia显示文摘 | Tracey K J Fong Y Hesse D G | 1987 | Nature1987，330，6149： | 1 |
| 7 | The evolution of benign arterionephrosclerosis from age 6 to 70 显示文摘 | Tracey RE Berenson G Waltigney W | 1990 | Am J Pathol1990，136，2： | 1 |
| 8 | Evidence of a central role for p38 map kinase induction of tumor necrosis factor alpha in pancreatitis associated pulmonary injury显示文摘 | Yang J Murphy C Denham W Botchkina G Tracey K J Norman J | 1999 | Surgery1999，126，： | 1 |
| 9 | Immune and inflammatory mechanisms in neuropathic pain显示文摘 | Moalem G Tracey DJ | 2006 | Brain research reviews2006，51，2： | 1 |
| 10 | Immune and inflammatory mechanisms in neuropathic pain显示文摘 | Moalem G Tracey DJ | 2006 | Brain Res Rev2006，51，2： | 1 |
| 11 | Alliances, networks and competitive strategy: rethinking cluster of innovation 显示文摘 | Tracey P & G L Clark | 2003 | Growth and Change2003，34，1： | 1 |
| 12 | Immune and inflammatory mechanisms in neuropathic pain 显示文摘 | Moalem G Tracey DJ | 2006 | Brain Res Rev2006，51，2： | 1 |
| 13 | painless,a Drosophila Gene Essential forNociception显示文摘 | TRACEY W D J R WILSON R I LAURENT G etal | 2003 | Cell2003，113，2： | 1 |
| 14 | Immune and inflammatory mechanisms in neu- ropathic pain显示文摘 | Moalem G Tracey DJ | 2006 | Brain Res Rev2006，51，2： | 1 |
| 15 | MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma显示文摘 | Tivnan A Tracey L Buckley P G | 2011 | BMC Cancer2011，11，33： | 1 |
| 16 | Micropower impulse radar:a Novel technology for rapid,real-time detection of pneumothorax显示文摘 | Phillip D L Tracey W Alan G | 2011 | Emergency Medicine International2011，，3： | 1 |
| 17 | The place of gold in rapid tests显示文摘 | JOHN C TRACEY G NICOLA R | 2000 | IVD Technology2000，6，2： | 1 |
| 18 | Relation of shyness with aspects of online relationship involvement显示文摘 | Ward C C Tracey T J G | 2004 | Journal of Social and Personal Relationships2004，21，： | 1 |
| 19 | Immune and inflammatory mechanisms in neuropathic pain显示文摘 | Moalem G Tracey D J | 2006 | Brain Res Brain Res Rev2006，51，： | 1 |
| 20 | Compensatory re- cruitment, growth and mortality as factors maintaining rain for- est tree diversity 显示文摘 | CONNELL J H TRACEY J G WEBB L J | 1984 | Ecological Monographs1984，54，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员