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| 1 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 2 | Variations in CaCO_3 content and Sr isotopic composition of loess and records of paleoclimatic fluctuations显示文摘The carbonate Sr isotopic composition of the Heimugou loess-paleosol section in Luochuan of Shaanxi Province shows large variation, with the 87 Sr/86 Sr ratios ranging from 0.7104 to 0.7120. The carbonate in paleosol has in general higher 87Sr/86Sr than the carbonate in loess. In the loess-paleosol section, the Sr isotopic composition vary with an about 100 | LIU Congqiang, ZHANG Jing, and LI ChunlaiState Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences ,Guiyang 550002, ChinaPresent address : Environmental Biology and Chemistry, Faculty of Sciences , Toyama University, Toyama 9308555, Japan | 1999 | Chinese Science Bulletin1999，44，16： | 6 |
| 3 | Harpagometabolins Ⅰ and Ⅱ, Two New Metabolites from Harpagoside by Human Intestinal Bacteria显示文摘Harpagoside, which is one main iridoid constituent of the dried roots of Scrophularia ningpoensis Hemsl., was biotransformated by bacteria isolated from human feeal flora a.d three metabolites were obtained. The structures of the metabolites, including two new alkaloids, named bar’Pagometabolins Ⅰ (l) and Ⅱ (2), and a known alkaloid acubinine B(3), were identified by chemical methods and the spectroscopic evidences. | Xiu Wei YANG Chen Ting ZOU Masao HATTORI National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083 Institute of Natural Products, Toyama Medical & Pharmaceutical University 2630 Sugitani, Toyama 930-01, Japan | 2000 | Chinese Chemical Letters2000，11，9： | 6 |
| 4 | SECI, Ba and Leadership: a Unified Model of Dynamic Knowledge Creation显示文摘 | Ikujiro Nonaka Ryoko Toyama Noboru Konno | 2000 | Long Range Planning2000，，1： | 5 |
| 5 | Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse显示文摘背景雌激素受体 alpha (嗯一)是最重要的内分泌的治疗应答预言者因为有对内分泌的治疗的反应的预言的胸 cancer.The 精确性的女人被认为被包含雌激素受体 coregulatory 蛋白质和串音在之间影响嗯并且另外的生长发信号因素的 networks.Nuclear corepressor 1 ( NCOR1 )是学习客观的抄写 repressor.The 是在蛋白质 le 调查 NCOR1 | ZHANG Zhen-huan Hiroko Yamashita Tatsuya Toyama Yutaka Yamamoto Teru Kawasoe Mutsuko lbusuki Saori Tomita Hiroshi Sugiura Shunzo Kobayashi Yoshitaka Fujii Hirotaka Iwase | 2009 | Chinese Medical Journal2009，，15： | 4 |
| 6 | Percoll fractionation of adult mouse spermatogonia improvesgerm cell transplantation显示文摘Aim: To isolate and transplant germ cells from adult mouse testes for transplantation. Methods: In order to distinguish transplanted cells from endogenous cells of recipients, donor transgenic mice expressing green fluorescent protein (GFP) were used. Germ cells were collected from the donors at 10-12 weeks of age and spermatogonia were concentrated by percoll fractionation and transplanted into recipient seminiferous tubules that had been previously treated with busulfan at 5 weeks of age to remove the endogenous spermatogenic cells. Results: Twenty weeks after the transplantation, a wide spread GFP signal was observed in the recipient seminiferous tubules. The presence of spermatogenesis and spermatozoa was confirmed in sections of 12 out of 14 testes transplanted (86%).However, when germ cells were transplanted without concentration the success rate was zero (0/9). Conclusion:Germ cells from adult mouse testes can be successfully transplanted into recipient seminiferous tubules if the cell population is rich in spermatogonia and the percoll fractionation is useful in obtaining such a cell population. | Kyu-Bom Koh Masatoshi Komiyama Yoshiro Toyama Tetsuya Adachi Chisato Mori | 2004 | Asian Journal of Andrology2004，6，2： | 3 |
| 7 | Accelerated degradation of a variety of aromatic compounds by Spirodela polyrrhiza-bacterial associations and contribution of root exudates released from S. polyrrhiza显示文摘Removal experiments of phenol,aniline,2,4-dichlorophenol,nonylphenol and bisphenol A(BPA) using Spirodela polyrrhizabacterial associations revealed that all compounds but BPA underwent accelerated removal.The mechanisms differed depending on the substrates.It was found that S.polyrrhiza has a great ability to release phenolic compound-rich root exudates,and the exudates seem to stimulate bacterial degradation of a variety of aromatic compounds. | Hai Hoang Ning Yu Tadashi Toyama Daisuke Inoue Kazunari Sei Michihiko Ike | 2010 | Journal of Environmental Sciences2010，22，4： | 3 |
| 8 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 9 | Microstructural analyses of all-solid-state Li–S batteries using LiBH4-based solid electrolyte for prolonged cycle performance显示文摘Complex hydride materials have been widely investigated as potential solid electrolytes because they have good compatibility with the lithium metal anodes used in all-solid-state batteries. However, the development of all-solid-state batteries utilizing complex hydrides has been difficult as these cells tend to have short cycle lives. This study investigated the capacity fading mechanism of all-solid-state lithium–sulfur(Li–S) batteries using Li4(BH4)3I solid electrolytes by analyzing the cathode microstructure. Crosssectional scanning electron microscopy observations after 100 discharge–charge cycles revealed crack formation in the Li4(BH4)3I electrolyte and an increased cathode thickness. Raman spectroscopy indicated that decomposition of the Li4(BH4)3I solid electrolyte occurred at a constant rate during the cycling tests.To combat these effects, the cycle life of Li–S batteries was improved by increasing the amount of solid electrolyte in the cathode. | Kazuaki Kisu Sangryun Kim Ryuga Yoshida Hiroyuki Oguchi Naoki Toyama Shin-ichi Orimo | 2020 | Journal of Energy Chemistry2020，29，11： | 3 |
| 10 | Lithium ion conductivity of complex hydrides incorporating multiple closo–type complex anions显示文摘We report the lithium ionic conductivities of closo –type complex hydrides synthesized from various molar ratios of lithium borohydride(LiBH4) and decaborane(B10H14) as starting materials. The prepared closo –type complex hydrides comprised [B12H12]^2-, [B11H11]^2-, and [B10H10]^2- complex anions. In addition, increasing the LiBH4 content in the starting materials increased the amounts of [B11H11]^2- and [B10H10]^2-, leading to an improved ion conductivity of the prepared sample. The present study offers useful insights into strategies for controlling the complex anion composition in emerging solid electrolytes of closo-type complex hydrides at the molecular level, and improving their ionic conductivities. | Naoki Toyama Sangryun Kim Hiroyuki Oguchi Toyoto Sato Shigeyuki Takagi Masaru Tazawa Genki Nogami Shin-ichi Orimo | 2019 | Journal of Energy Chemistry2019，28，11： | 2 |
| 11 | Development of ultra-precision grinder for machining aspheric surface显示文摘 | TOYAMA T | 1992 | Toyota Machinery Report1992，32，3： | 2 |
| 12 | Fracture toughness of medium-high carbon steel for railroad wheel显示文摘 | Haruo Sakamoto Kazuo Toyama Kenji Hirakawa | 2000 | Materials Science & Engineering A2000，，1： | 2 |
| 13 | Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion显示文摘 | Yi-Fei Dong Keiichiro Kataoka Kensuke Toyama Daisuke Sueta Nobutaka Koibuchi Eiichiro Yamamoto Kenichiro Yata Hidekazu Tomimoto Hisao Ogawa Shokei Kim-Mitsuyama | 2011 | Hypertension2011，，4： | 2 |
| 14 | Accelerated biodegradation of nitrophenols in the rhizosphere of Spirodela polyrrhiza显示文摘We investigated the biodegradation of 2-nitrophenol (2-NP), 4-nitrophenol (4-NP), and 2,4-dinitrophenol (2,4-DNP) in the rhizosphere of Spirodela polyrrhiza plants by conducting degradation experiments with three river water samples supplemented with each nitrophenol (NP). We then isolated NP-degrading bacteria both from the S. polyrrhiza roots and from the river water. In the river water samples, removal of the three NP was accelerated in the presence of S. polyrrhiza plants. The three NPs persisted in an autoclaved solution with sterile plants suggests that NP removal was accelerated largely by bacterial NP biodegradation rather than by adsorption and uptake by the plants. We isolated 8 strains of NP-degrading bacteria: 6 strains from the S. polyrrhiza roots and 2 strains from river water without the plants. The 2-NP- and 2,4-DNP-degrading bacteria were isolated only from the S. polyrrhiza roots. The 4-NP- degrading bacteria different from those isolated from the river water samples were also found on S. polyrrhiza roots. The 2-NP- and 4-NP-degrading strains isolated from the roots utilized the corresponding NP (0.5 mmol/L) as the sole carbon and energy source. The 2,4-DNP-degrading strains isolated from the roots showed substantial 2,4-DNP-degrading activity, but the presence of other carbon and energy sources was required for their growth. The isolated NP-degrading bacteria from the roots must have contributed to the accelerated degradation of the three NPs in the rhizosphere of S. polyrrhiza. Our results suggested that rhizoremediation with S. polyrrhiza may be effective for NP-contaminated surface water. | Risky Ayu Kristanti Masahiro Kanbe Tadashi Toyama Yasuhiro Tanaka Kazuhiro Mori | 2012 | Journal of Environmental Sciences2012，24，5： | 2 |
| 15 | Antibacterial properties of AM-1155, a new 8-methoxy quinolone 显示文摘 | Hosaka M Kinoshita S Toyama A | 1995 | J Antimicrob Chemther1995，36，： | 2 |
| 16 | Antibacterial properties of AM-1155, a new 8-methoxy quinolone 显示文摘 | Hosaka M Kinoshita S Toyama A | 1995 | J Antimicrob Chemother1995，36，： | 2 |
| 17 | The role of three dimensional computed tomography in the management of maxiilofacial bone fractures显示文摘 | Ohkawa M Tanabe M Toyama N | 1997 | Acta Med Okayama1997，51，4： | 1 |
| 18 | Combined therapy with carvedilol and amiodarone is more effective in improving cardiac symptoms, function and sympathetic nerve actively in patients with dilated cardiomyopathy: comparison with carvedilol therapy alone显示文摘 | Toyama T Hoshizaki H Yoshimura Y | 2008 | Nucl Cardiol2008，15，1： | 1 |
| 19 | SECI,Ba and leadership:a uni fied model of dynamic knowledge creation显示文摘 | Nonaka I Toyama R Konno N | 2000 | Long Range Planning2000，33，1： | 1 |
| 20 | Long-term outcomes of standard discectomy for lumbar disc herniation:A follow-up study of more than 10 years显示文摘 | Yorimitsu E Chiba K Toyama Y | 2001 | Spine2001，26，6： | 1 |
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