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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 3 | Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair显示文摘Peripheral nerve regeneration requires stepwise and well-organized establishment of microenvironment.Since local delivery of VEGF-A in peripheral nerve repair is expected to promote angiogenesis in the microenvironment and Schwann cells(SCs)play critical role in nerve repair,combination of VEGF and Schwann cells may lead to efficient peripheral nerve regeneration.VEGF-A overexpressing Schwann cells were established and loaded into the inner wall of hydroxyethyl cellulose/soy protein isolate/polyaniline sponge(HSPS)conduits.When HSPS is mechanically distorted,it still has high durability of strain strength,thus,can accommodate unexpected strain of nerve tissues in motion.A 10 mm nerve defect rat model was used to test the repair performance of the HSPS-SC(VEGF)conduits,meanwhile the HSPS,HSPS-SC,HSPS-VEGF conduits and autografts were worked as controls.The immunofluorescent co-staining of GFP/VEGF-A,Ki67 and MBP showed that the VEGF-A overexpressing Schwann cells could promote the proliferation,migration and differentiation of Schwann cells as the VEGF-A was secreted from the VEGF-A overexpressing Schwann cells.The nerve repair performance of the multifunctional and flexible conduits was examined though rat behavioristics,electrophysiology,nerve innervation to gastrocnemius muscle(GM),toluidine blue(TB)staining,transmission electron microscopy(TEM)and NF200/S100 double staining in the regenerated nerve.The results displayed that the effects on the repair of peripheral nerves in HSPS-SC(VEGF)group was the best among the conduits groups and closed to autografts.HSPS-SC(VEGF)group exhibited notably increased CD31+endothelial cells and activation of VEGFR2/ERK signaling pathway in the regenerated nerve tissues,which probably contributed to the improved nerve regeneration.Altogether,the comprehensive strategy including VEGF overexpressing Schwann cells-mediated and HSPS conduit-guided peripheral nerve repair provides a new avenue for nerve tissue engineering. | Ping Wu Zan Tong Lihua Luo Yanan Zhao Feixiang Chen Yinping Li Céline Huselstein Qifa Ye Qingsong Ye Yun Chen | 2021 | Bioactive Materials2021，6，10： | 4 |
| 4 | Near-fault ground motions with prominent acceleration pulses:pulse characteristics and ductility demand显示文摘Major earthquakes of last 15 years (e.g., Northridge 1994, Kobe 1995 and Chi-Chi 1999) have shown that many near-fault ground motions possess prominent acceleration pulses. Some of the prominent ground acceleration pulses are related to large ground velocity pulses, others are caused by mechanisms that are totally different from those causing the velocity pulses or fling steps. Various efforts to model acceleration pulses have been reported in the literature. In this paper, research results from a recent study of acceleration pulse prominent ground motions and an analysis of structural damage induced by acceleration pulses are summarized. The main results of the study include: (1) temporal characteristics of acceleration pulses; (2) ductility demand spectrum of simple acceleration pulses with respect to equivalent classes of dynamic systems and pulse characteristic parameters; and (3) estimation of fundamental period change under the excitation of strong acceleration pulses. By using the acceleration pulse induced linear acceleration spectrum and the ductility demand spectrum, a simple procedure has been developed to estimate the ductility demand and the fundamental period change of a reinforced concrete (RC) structure under the impact of a strong acceleration pulse. | Mai Tong Vladimir Rzhevskyt Dai Junwu George C Lee Qi Jincheng Qi Xiaozhai | 2007 | Earthquake Engineering and Engineering Vibration2007，6，3： | 3 |
| 5 | Fuzzy adaptive control for a class of nonlinear systems显示文摘 | TONG S C CHAI T Y | 1999 | Fuzzy Sets and Systems1999，10，2： | 2 |
| 6 | Fuzzy direct adaptive control for a class of nonlinear systems显示文摘 | CHAI T Y TONG S C | 1999 | Fuzzy Sets and Systems1999，103，3： | 2 |
| 7 | Superior safety of direct oral anticoagulants compared to Warfarin in patients with atrial fibrillation and underlying cancer: a national veterans affairs database study显示文摘Background Studies evaluating safety of warfarin and direct oral anticoagulants(DOACs) for prevention of stroke in patients with atrial fibrillation(AF) are lacking. Methods & Results All patients(n = 196,521) receiving care at veteran’s affairs with active cancer and AF from 2010–2015 were included. One-year mortality was significantly higher in unadjusted analysis with warfarin(44.9%) compared to dabigatran(25%, P < 0.001), rivaroxaban(24.4%, P < 0.001) and apixaban(30%, P < 0.001) and after adjusting for age, sex and type of cancer mortality(OR = 2.66, 95% CI: 2.52–2.82, P < 0.001). Risk of ischemic stroke(13.5% vs. 11.1%, 12.0%, 14.0%) was similar, however risk of hemorrhagic stroke was significantly higher among patients receiving warfarin(1.2%) compared to patients receiving dabigatran(0.5%), rivaroxaban(0.7%) and apixaban(0.8%) respectively, P = 0.04. Conclusions We demonstrated the superior safety profile of DOACs compared to warfarin among patients with underlying cancer and AF. Warfarin was associated with higher mortality, similar ischemic stroke risk but higher risk of hemorrhagic stroke. | Abhishek C Sawant Arnav Kumar Wilmon Mccray Sheldon Tetewsky Linda Parone Srilekha Sridhara Meghana Prakash Hiriyur Prakash Gary Tse Tong LIU Nidhi Kanwar Aishwarya Bhardwaj Sahoor Khan Christopher Manion Ankush Lahoti Ashish Pershad Peter Elkin John Corbelli | 2019 | Journal of Geriatric Cardiology2019，16，9： | 2 |
| 8 | Numerical studies of powerful terahertz pulse generation from a super-radiant surface wave oscillator显示文摘 | ZHANG H WANG J G TONG C J | | 0，，12： | 2 |
| 9 | A study of lubricants on silver flakes for microelectronicsconductive adhesive 显示文摘 | Lu D Tong Q K Wong C P | 1999 | IEEE Trans Compon Packg Manuf Tech Part A1999，22，3： | 2 |
| 10 | Thermophilic Aerobic Digestion - a Reliable and Effective Process for Sludge Treatment at Small Works 显示文摘 | Murray K C Tong A | 1990 | Wat Sci Tech1990，22，34： | 1 |
| 11 | Development and validation of an all-cause mortality risk score in type 2 diabetes显示文摘 | Yang X So W Y Tong P C | 2008 | Arch Intern Med2008，168，5： | 1 |
| 12 | Chemical hazards to agricultural workers显示文摘 | Tong T | 1991 | Occupational Medicine:State of the Art Reviews1991，6，3： | 1 |
| 13 | Efficient estimation for semivarying-coefficient models显示文摘 | Zhang W Y Tong H | 2004 | Biometrika2004，91，： | 1 |
| 14 | Single-index volatility models and estimation显示文摘 | Xia Y C Tong H Li W K | 2002 | Statistica Sinica2002，12，3： | 1 |
| 15 | Civil Service Reform in the People's Republic of China: Case Studies of Early Implementa- tion 显示文摘 | Tong C H Stranssman J D Broadnax W D | 1999 | Public Administration and Development1999，19，2： | 1 |
| 16 | Effect of valsartan and captopril in rabbit carotid injury:possible involvement of bradykinin in the anti-proliferative action of the reninangiotensin blockade显示文摘 | Tong C F Ying W Y Hua R Y | 2001 | JRAAS2001，2，1： | 1 |
| 17 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 18 | Vascμlar endothelial growth factor is an autocrine growth factor for VEGF receptor-positive human tumors显示文摘 | Rizwan M Jie C Tong Z | 2001 | Blood2001，98，6： | 1 |
| 19 | Tacrolimus for induction therapy of diffuse proliferative lupus nephritis:an open-labeled pilot study显示文摘 | MOK C C TONG K H TOC H | 2005 | Kidney Int2005，68，2： | 1 |
| 20 | MicroRNA profile analysis of human prostate canc- ers 显示文摘 | Tong A W Fulgham P Jay C Chen P Khalil I Liu S | 2009 | Cancer Gene Ther2009，16，： | 1 |
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