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| 1 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 2 | Chronic rejection after liver transplantation:Opening the Pandora’s box显示文摘Chronic rejection(CR)of liver allografts causes damage to intrahepatic vessels and bile ducts and may lead to graft failure after liver transplantation.Although its prevalence has declined steadily with the introduction of potent immunosuppressive therapy,CR still represents an important cause of graft injury,which might be irreversible,leading to graft loss requiring re-transplantation.To date,we still do not fully appreciate the mechanisms underlying this process.In addition to T cell-mediated CR,which was initially the only recognized type of CR,recently a new form of liver allograft CR,antibody-mediated CR,has been identified.This has indeed opened an era of thriving research and renewed interest in the field.Liver biopsy is needed for a definitive diagnosis of CR,but current research is aiming to identify new non-invasive tools for predicting patients at risk for CR after liver transplantation.Moreover,the minimization or withdrawal of immunosuppressive therapy might influence the establishment of subclinical CR-related injury,which should not be disregarded.Therapies for CR may only be effective in the“early”phases,and a tailored management of the immunosuppression regimen is essential for preventing irreversible liver damage.Herein,we provide an overview of the current knowledge and research on CR,focusing on early detection,identification of non-invasive biomarkers,immunosuppressive management,re-transplantation and future perspectives of CR. | Roberta Angelico Bruno Sensi Tommaso M Manzia Giuseppe Tisone Giuseppe Grassi Alessandro Signorello Martina Milana Ilaria Lenci Leonardo Baiocchi | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 3 | Predicted Effects of Treatment for HCV Infection Vary Among European Countries显示文摘 | Sylvie Deuffic–Burban Pierre Deltenre Maria Buti Tommaso Stroffolini Julie Parkes Nikolai Mühlberger Uwe Siebert Christophe Moreno Angelos Hatzakis William Rosenberg Stefan Zeuzem Philippe Mathurin | 2012 | Gastroenterology2012，，4： | 2 |
| 4 | Oxidative stress and endothelial dysfunction: Therapeutic implications显示文摘 | Tommaso Gori Thomas Münzel | 2011 | Annals of Medicine2011，，4： | 2 |
| 5 | Major complications following endovascular surgery of descending thoracic aorta 显示文摘 | Di Tommaso L Monaco M Mottola M et at | 2006 | Interact Cardiovasc Thorac Surg2006，5，6： | 1 |
| 6 | Wireless multimedia sensor network: a survey显示文摘 | Ian F A Tommaso M Kaushik R C | 2007 | IEEE Wireless Communications2007，14，6： | 1 |
| 7 | Primary pulmonary meningioma: Report of a case and re- view of the literature 显示文摘 | INCARBONE M CERESOLI GL DI TOMMASO L | 2008 | Lung Cancer2008，62，3： | 1 |
| 8 | A survey on wireless multimedia sensor networks显示文摘 | AKYILDIZ I F TOMMASO M CHOWDHURY K R | 2007 | Computer Networks2007，51，4： | 1 |
| 9 | Insomnia, quality of life and psychopathological features 显示文摘 | Specchio LM Prudenzano MP de Tommaso M | 2004 | Brain Res Bull2004，63，5： | 1 |
| 10 | Advanced precancer- ous lesions in the liver显示文摘 | Tommaso L D Sangiovanni A Borzio M | 2013 | Best Practice & Research Clinical Gastro- enterology2013，27，2： | 1 |
| 11 | Steady-state visual evoked potentials and phase synchronization in migraine patients显示文摘 | Angelini L De Tommaso M Guido M | 2004 | Phys Rev Lett2004，93，03： | 1 |
| 12 | Ad- vanced precancerous lesions in the liver显示文摘 | DI TOMMASO L SANGIOVANNI A BORZIO M | 2013 | Best Pract Res Clin Gastroenterol2013，27，2： | 1 |
| 13 | A novel device for the collection,storage,transport and delivery of beneficial insects and its application to Ophraella communa (Coleoptera:Chrysomelidae)显示文摘 | Teshler M P Dernovic S A Di Tommaso A Coderre D Watson A K | 2004 | Biocontrol Science & Technology2004，14，： | 1 |
| 14 | Uterine fibroids affect pregnancy out- come in women over 30 years old : role of other risk factors 显示文摘 | Conti N Tosti C Pinzauti S Tomaiuolo T Cevenini G Severi FM Di Tommaso M Petraglia F | 2013 | Matem Fetal Neonatal Med2013，26，6： | 1 |
| 15 | Laser evoked potentials in carpal tunnel syndrome 显示文摘 | Tommaso M Libro G Difuscolo O | 2009 | Clin Neuro2009，120，： | 1 |
| 16 | Influence of aesthetic perception on visual event-related potentials显示文摘 | de Tommaso M Pecoraro C Sardaro M Serpino C Lancioni G & Livrea P | | 0，，： | 1 |
| 17 | Systematic strategyof prophylactic coronary angiography improves long-term outcomeafter major vascular surgery in medium to high - risk patients: aprospective, randomized study 显示文摘 | Monaco M Stassano P Di Tommaso L | 2009 | J Am Coll Cardiol2009，54，： | 1 |
| 18 | The abnormal intracephalic transfer of dermatodynia in chronic migraineurs 显示文摘 | Tommaso M Valeriani M Guide M | 2003 | Pain2003，101，： | 1 |
| 19 | Determinationof mono-and disaccharides in milk and milk products by high-performance anion-exchange chromatography with pulsedamperometric detection显示文摘 | TOMMASO R I ANGELOTTI C M BIANCO G | 2003 | Anal Chim Acta2003，485，： | 1 |
| 20 | Heat Pain Thresholds and Cerebral Event-related Potentials Following Painful CO2 Laser Stimulation in Chronic Tension-type Headache显示文摘 | DE TOMMASO M LIBRO G GUIDO | 2003 | Pain2003，104，12： | 1 |
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