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| 1 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 2 | 施万细胞在阴茎和外周神经再生中的作用显示文摘施万细胞(SCs)是外周神经系统中主要的胶质细胞。施万细胞最终发育为形成髓鞘的细胞和不形成髓鞘的细胞,前者包绕直径较大的神经,后者则包绕直径较小的神经。他们在神经损伤后的再生中发挥重要作用,包括海绵体神经损伤导致的勃起功能障碍(ED)。尽管前列腺癌根治术手术技术有所提高,但是仍有相当一部分患者术后出现ED。这是由于术中牵拉损伤或局部炎症反应改变了自主神经的微环境,最终导致终末器官-阴茎的病理生理改变。该综述目的是总结现有的如下方面相关文献:(1)外周神经特别是阴茎神经中施万细胞的起源和发育;(2)外周神经特别是阴茎神经损伤后的Wallerian变性和施万细胞的可塑性;(3)施万细胞如何通过分泌神经生长因子促进神经再生;(4)以施万细胞作为治疗靶点促进神经再生的技术。我们搜索了Pubmed,发现了为数众多的与上述主题相关的动物实验和人体研究,这提示施万细胞有望成为神经源性ED治疗的新靶点。 | Lin Wang Melissa T Sanford Zhongcheng Xin Guiting Lin Tom F Lue | 2015 | Asian Journal of Andrology2015，17，5： | 7 |
| 3 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 4 | Diagnostic and therapeutic approach to cholestatic liver disease显示文摘 | Pérez Fernandez T López Serrano P Tomás E | | 0，，01： | 1 |
| 5 | Oxidation of TiB2 powders below 900 :C 显示文摘 | Kulpa A Tom T | 1996 | Journal of America Ceramic Society1996，79，2： | 1 |
| 6 | Freely dispersible Au @TiOz, Au@ZrO2, Ag@TiO2, and Ag@ZrOz core-shell nanoparticles: One-step synthesis, characterization, spec- troscopy, and optical limiting properties 显示文摘 | Tom R T Nair A S Singh N | 2003 | Langmuir2003，19，8： | 1 |
| 7 | Paraquat-induced gene expression in rat kidney显示文摘 | Tom Ita M Oku Yama T Ka Tsu Yama H | 2006 | Arch Toxicol2006，80，10： | 1 |
| 8 | Adaptive histogram equalization and itsapplications 显示文摘 | Tom V T Wolfe G J | 1983 | SPIE1983，359，： | 1 |
| 9 | Understanding Shipper-Cartier and Shipper-Warehouser Relationships: Partnerships Revisited显示文摘 | Gardner John T Martha C Cooper Tom Noordewier | 1994 | Journal of Business Logistics1994，15，2： | 1 |
| 10 | Developmental effects of endocrine-disrupting chemicals in wildlife and humans显示文摘 | COLBRON T TOM S F S SOTO A M | 1993 | Environ Health Prospect1993，101，5： | 1 |
| 11 | Effects of drug combinations on smooth muscle cell proliferation:an isobolographic analysis显示文摘 | Tom JP Rathna T Dennis A | 2006 | Eur J Pharmacol2006，532，12： | 1 |
| 12 | CT guided radiofrequency ablation of spinal osteoid osteomas with concomitant perineural and epidural irrigation for neuroprotection显示文摘 | Klass D Marshall T Toms A | 2009 | Eur Radiol2009，19，9： | 1 |
| 13 | Reconstruction of fernoral defects in revision hip surgery : risk of fracture and stemmigration afeer impaction bone grafting显示文摘 | Barker R Takahashi T Toms A | 2006 | J Bone Joint Surg Br2006，88，6： | 1 |
| 14 | Performance of floation and sunkenmedia biological aerated filters under unsteady conditions 显示文摘 | T MANN ALLAN MENDOZA - ESPINOSE LEOPOLDO STEPHEN - SON TOM | 1999 | Water Res1999，33，4： | 1 |
| 15 | Diagnostic accuracy of magnetic resonance imaging and magnetic resonance arthrogra- phy for triangular fibrocartilaginous complex injury: a systemat- ic review and recta-analysis显示文摘 | Smith T O Drew B Toms A P | 2012 | J Bone Joint Surg Am2012，94，9： | 1 |
| 16 | Analysis of heat transfer in a vessel with helical pipe coil and multistage impeller 显示文摘 | Martin Dostál Marcela Vě?í?ová Karel Petera Tomá? Jirout Ivan Fo?t | 2014 | The Canadian Journal of Chemical Engineering2014，92，： | 1 |
| 17 | Repair of alveolar clefts with recombinant human bone morphogenetic protein (rh- BMP-2) in patients with clefts显示文摘 | Chin M Ng T Tom WK | 2005 | J Craniofac Sttrg2005，16，5： | 1 |
| 18 | I-dentification of RAPD markers linked to digestive amylase genes using near isogenic lines of the silk-worm,Bombyx mori显示文摘 | Ashwath S K Sreekumar S Toms J T | | 0，，84： | 1 |
| 19 | Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains显示文摘 | Cha T A Tom E Kemble G W | 1996 | Journal of Virology1996，70，1： | 1 |
| 20 | In search of energy security显示文摘 | JAMES T B MARK A B TOM L T | 2005 | RAND Review2005，29，3： | 1 |
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