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| 1 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 2 | 可变轨距转向架的开发显示文摘介绍了为可变轨距电动车组开发的A型和B型2种可变轨距转向架,阐述了这2种转向架的结构和轨距变换的具体实现过程。 | Noriaki TOKUDA 周贤全 | 2006 | 国外铁道车辆2006，43，1： | 11 |
| 3 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 4 | 带DDM独立车轮转向架的结构及其高速运行性能显示文摘介绍了日本开发的DDM独立车轮可变轨距转向架的结构及其高速性能试验结果。 | Noriaki TOKUDA(等 周冬妍(译) 刘宏友(校) | 2010 | 国外铁道车辆2010，，6： | 4 |
| 5 | A case of mucosa-associated lymphoid tissue lymphoma of the gastrointestinal tract showing extensive plasma cell differentiation with prominent Russell bodies显示文摘A 73-year-old Japanese woman was hospitalized for detailed examination of nausea, diarrhea and loss of appetite. Atypical erosion in the ileum was found on endoscopy. Biopsy of this erosion showed proliferation of cells containing numerous Russell bodies. Differential diagnoses considered were Russell body enteritis, crystal-storing histiocytosis, Mott cell tumor, immunoproliferative small intestinal disease(IPSID) and mucosaassociated lymphoid tissue(MALT) lymphoma. The cells containing prominent Russell bodies showed diffuse positivity for CD79 a and CD138, but negative results for CD20, CD3, UCHL-1, CD38 and CD68. Russell bodies were diffusely positive for lambda light chain, but negative for kappa light chain, and immunoglobulin(Ig)G, Ig A and Ig M. Based on these findings, Russell body enteritis, crystal-storing histiocytosis and IPSID were ruled out. As the tumor formed no mass lesions and was restricted to the gastrointestinal tract, MALT lymphoma with extensive plasma cell differentiation was finally diagnosed. The patient showed an unexpectedly aggressive clinical course. The number of atypical lymphocytes in peripheral blood gradually increased and T-prolymphocytic leukemia(T-PLL) emerged. The patient died of T-PLL 7 mo after admission. Autopsy was not permitted. | Keita Kai Masaharu Miyahara Yasunori Tokuda Shinich Kido Masanori Masuda Yukari Takase Osamu Tokunaga | 2013 | World Journal of Clinical Cases2013，1，5： | 4 |
| 6 | Efficient Fixation of Carbon Dioxide by Electrolysis——Facile Synthesis of Useful Carboxylic Acids显示文摘Electrochemical fixation of atmospheric pressure of carbon dioxide to organic compounds is a useful and attractive method for synthesizing of various carboxylic acids. Electrochemical fixation of carbon dioxide, electrochemical carboxylation, organic halides, organic triflates, alkenes, aromatic compounds, and carbonyl compounds can readily occur in the presence of an atmospheric pressure of carbon dioxide to form the corresponding carboxylic acids with high yields, when a sacrificial anode such as magnesium or aluminum is used in the electrolysis. The electrochemical carboxylation of vinyl bromides was successfully applied for the synthesis of the precursor of nonsteroidal anti-inflammatory agents such as ibuprofen and naproxen. On the other hand, supercritical carbon dioxide (scCO2) has significant potential as an environmentally benign solvent in organic synthesis and it could be used both as a solvent and as a reagent in these electrochemical carboxylations by using a small amount of cosolvent. | Masao Tokuda | 2006 | Journal of Natural Gas Chemistry2006，15，4： | 3 |
| 7 | CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers显示文摘Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers.Methods We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the groups.Markers that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal PD.Results Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy controls.Assessing the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was generated.Conclusions The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal stage.Our findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD. | Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 8 | Flow Behavior in Z-Path Fluidized-Moving Bed with Inclined Perforated Plate显示文摘The flow behaviors in a gas-solid contactor with inclined perforated plates that form a zigzag path were experimentally studied. In this contactor solid particles slide down along the inclined perforated plates by the upflowing gas. This structure, called as 'z-path-moving bed', has some of the advantages of both moving and fluidized beds. The discharge rate of solid particles, inclination angle of the perforated plate, aperture ratio of the perforated plate, size of particles and gas velocity were chosen as parameters for experimental conditions. The stable operation conditions were certained for the particles and apparatus used. The pressure drop, bed height and residence time distribution of particles were measured versus gas velocity. | GUO Zhan-cheng TOKUDA Masanori | 2002 | Journal of Iron and Steel Research(International)2002，9，1： | 2 |
| 9 | Study on Solubility of Nb_2O_5 in KOH Solution and Alkali Leaching of Niobite显示文摘Solubility of Nb 2O 5 and leaching behaviors of Nb and Ta from niobite in KOH solution have been investigated in order to develop an alkali hydrothermal leaching process of Nb and Ta. The solubility of Nb 2O 5 was measured in the range of 40 ℃ to 200 ℃ at various molar ratios of K 2O to Nb 2O 5 ( n (K 2O)/ n (Nb 2O 5)). It has been found that Nb 2O 5 shows the maximum solubility at the solution composition of n (K 2O)/ n (Nb 2O 5)=4/3 at a given temperature; the rise of temperature increases the solubility of Nb 2O 5 below 120 ℃, but decreases it above 120 ℃. The leaching behaviors of Nb and Ta were studied in the range of 150 ℃ to 250 ℃ and 0.1 MPa to 5 MPa. With the rise of temperature, the leaching degree increases when the leaching temperature is below 200 ℃, but it decreases when the leaching temperature is above 200 ℃. The maximum leaching degree is about 90% at 200 ℃. It was proved that the alkali hydrothermal leaching process is effective for the recovery of Nb and Ta from niobite concentrate. | ZHOU Kang gen 1,TOKUDA Masanori 2 (1.Metallurgical Separation Science and Engineering Lab., Central South University, Changsha 410083, China 2.Tohoku University, Sendai 980 77, Japan) | 2000 | Journal of Central South University2000，12，4： | 2 |
| 10 | 带直接驱动电机的独立车轮系统转向架的结构及其在高速时的性能显示文摘开发了一种用于可变轨距列车的新概念转向架,其既适用于1435mm标准轨距线路,也适用于1067mm米轨线路。这种转向架必须在高速运行于标准轨距线路上时具有良好的运行稳定性,同时还必须在米轨线路的弯道上运行时具有高的运行性能。采用一种直接驱动的电动机系统以使电动机能被直接安装到车轮上,从而获得一种独立的车轮系统和轮对导向系统。由于具有短的轴距,所以独立车轮系统使得转向架在高速时具有良好的运行稳定性。在车辆滚动试验台上对这种转向架的样机进行了试验,试验结果表明,在500km/h的最大速度下并没有发现任何运行稳定性方面的问题。还在美国科罗拉多州普伟布洛运输技术中心公司对这种转向架进行了试验,随后又在日本山阳新干线上对其进行了超过200km/h的高速运行试验。 | Noriaki TOKUDA 苏明 | 2010 | 国外内燃机车2010，，2： | 2 |
| 11 | Risk factors for acute myocardial infarction among Okinawans显示文摘 | Tokuda Y | 2005 | J Nutr Health Aging2005，9，4： | 1 |
| 12 | A surface plasmon resonance immunosensor for detecting a dioxin precursor using a gold binding polypeptide显示文摘 | Sob N Tokuda T Watanabe T | 2003 | Talanta2003，60，4： | 1 |
| 13 | Strong-Coupled polaronvia the deformation polential显示文摘 | | 1980 | Solid state Comman1980，35，： | 1 |
| 14 | Intrapleural fibrinolytic agents for empyema and complicated parapneumonie effusions:a recta-analysis显示文摘 | Tokuda Y Matsushima D Stein GH | 2006 | Chest2006，129，3： | 1 |
| 15 | Mechanismof simvastatin on induction of heat shock protein in osteoblasts 显示文摘 | WANG X TOKUDA H HATAKEYAMA D | 2003 | Arch Biochem Biophys2003，415，1： | 1 |
| 16 | Mechanism of simvastatin on induction of heat shock protein in osteoblasts显示文摘 | Wang X Tokuda H Hatakeyama D | | 0，，01： | 1 |
| 17 | Triterpene acids from Poria cocos and their anti-tumor-promoting effects显示文摘 | Akihisa T Nakamura Y Tokuda H Uchiyama E Suzuki T Kimura Y | | 0，，06： | 1 |
| 18 | Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization显示文摘 | Kai H Kuwahara F Tokuda K | | 0，，2： | 1 |
| 19 | Mechanism of simvastatin on induction of heat shock protein in osteoblasts显示文摘 | Wang X Tokuda H Hatakeyama D | 2003 | Arch Biochem Biophys2003，415，1： | 1 |
| 20 | A Variational approach to the polaaron problem显示文摘 | | 1980 | J Phys1980，13，： | 1 |
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