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| 1 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 2 | A novel method for metal oxide deposition on carbon aerogels with potential application in capacitive deionization of saline water显示文摘 | M.C. Zafra P. Lavela G. Rasines C. Macías J.L. Tirado C.O. Ania | 2014 | Electrochimica Acta2014，，： | 2 |
| 3 | Human decidual stromal cells express HLA-G:Effects of cytokines and decidualization显示文摘 | Blanco O Tirado I Munoz-Fernandez R | 2008 | Hum Reprod2008，23，： | 1 |
| 4 | Water exchanges versus water works: Insights from a computable general equilibrium model for the Balearic Islands显示文摘 | GOMEZ C M TIRADO D REY-MAQUIEIRA J | 2004 | Water Resources Research2004，40，： | 1 |
| 5 | Wastewater treatment sludge as a raw material for the production of Bacillus thouringinsib based biopesticides显示文摘 | Maria De Lourdes Tirado Montiel Tyagi R D Valero J R | 2001 | Wat Res2001，35，16： | 1 |
| 6 | Meiotic Arrest and Germ Cell Apoptosis in Androgen-binding Protein Transgenic Mice显示文摘 | SELVA D M TIRADO O M TORdN N | 2000 | Endocrinology2000，141，3： | 1 |
| 7 | Computational analysis of human adenovirus serotype 18显示文摘 | Walsh MP Seto J Tirado D | 2010 | Virology2010，404，2： | 1 |
| 8 | New doped Li-M-Mn-O(M=AI, Fe, Ni) spinels as cathodes for rechargeable 3V lithium batteries 显示文摘 | MORALES J SANCHEZ L TIRADO J | 1999 | J Solid Electrochemica Acta1999，45，： | 1 |
| 9 | New doped Li-M-Mn-O( M = A1, Fe, Ni) spinels as cathodes for rechargeable 3 V lithium batteries 显示文摘 | Morales J S6nchez L Tirado J L | 1998 | Journal of Solid State Electrochemistry1998，2，： | 1 |
| 10 | Low complexity bit-parallel multipliers based on a class of irreducible pentanomials 显示文摘 | IMANA J L HERMIDA R TIRADO F | 2006 | IEEE Transactions on VLSI Systems2006，14，12： | 1 |
| 11 | Caveolin-1(CAV1) is a target of EWS/FL I-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells显示文摘 | Tirado OM Mateo-Lozano Silvia Joaquen Villar | 2006 | Cancer Res2006，66，20： | 1 |
| 12 | Shrub spatial aggregation and consequences for reproductive success显示文摘 | Reyes Tirado Francisco I. Pugnaire | 2003 | Oecologia2003，，2： | 1 |
| 13 | Infantile mixed phenotype acute leukemia ( bilineal and biphenotypic) with t( 10 ; 11 ) ( p12 ; q23 ) ; MLL - MLLT10 显示文摘 | Lou Z Zhang CC Tirado CA | 2010 | Leuk Res2010，34，8： | 1 |
| 14 | New Doped Li-M-Mn-O( M = Al, Fe, Ni) Spinels as Cathodes for Rechargeable 3V Lithium Batteries 显示文摘 | Morales J Sanchez L Tirado J L | 1998 | J Solid State Electrochem1998，，2： | 1 |
| 15 | Garcia-Hernandes显示文摘 | Hamilton P B Tirado F J | 1990 | Poultry Science1990，69，： | 1 |
| 16 | WHO surveillance programme for controlof food-borne infections and intoxications: preliminary results and trends across greater Europe 显示文摘 | Tirado C Schimdt K | 2001 | Infect2001，43，： | 1 |
| 17 | Surgical treatment of spinal tuberculosis:an orthopedic service experience显示文摘 | Soares do Brito J Batista N Tirado A | 2013 | Acta Med Port2013，26，4： | 1 |
| 18 | Cerebrovascular accidents and atrial fibrillation in the elderly paient显示文摘 | Alcalde Tirado P Ribera Casado JM | 1995 | An Med Intensa1995，12，8： | 1 |
| 19 | Information literacy competency standards for higher education and their correlation with the cycle of knowledge generation 显示文摘 | Tirado A U Mufioz W C | 2012 | Liber Quarterly : The Journal of European Research Libraries2012，22，3： | 1 |
| 20 | Electrochemical re- action of lithium with CoP:~ 显示文摘 | Alcantara R Tirado J Jumas J | 2002 | Journal of Power Sources2002，109，2： | 1 |
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