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| 1 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 2 | Synthesis of 4-functionalized terdendate pyridine ligands 显示文摘 | Tina V Danuta B Antonius T M | 2003 | Tetrahedron2003，59，27： | 1 |
| 3 | Scaling laws for light-weight optica显示文摘 | TINA M V | 1990 | SPIE1990，1340，： | 1 |
| 4 | Isotopic Analysis of Cd in the Mixing Zone of Siberian Rivers with the Arctic Ocean--New Constraints on Marine Cd Cycling and the Isotope Composition of Riverine Cd 显示文摘 | Myriam L Mark R Tina V F | 2013 | Earth and Planetary Science Letters2013，361，： | 1 |
| 5 | Laparoscopic intracavitary de-bridement of peripancreatic necrosis显示文摘 | John A Thomas V Tina D | 2000 | Surgery2000，127，1： | 1 |
| 6 | Solid-state phase equilibria in the Mg corner of the Mg-Gd-Sm phase diagram显示文摘 | Rkhlin L L NiKítina N I Dobatkina T V | 1996 | Journal of Alloys and Compounds1996，239，： | 1 |
| 7 | Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells 显示文摘 | PETER H MIRIAM B TINA V | 2004 | Protein Engineering Design and Selection2004，17，5： | 1 |
| 8 | Lorenzob chlorophylls in foods显示文摘 | Schwartza S J Tina V | | 0，，01： | 1 |
| 9 | Bayesian Meta-Analysis of Genetic Association Studies with Different Sets of Markers 显示文摘 | Claudio V Tina S Juan P Casas | 2008 | The American Journal of Human Genetics2008，82，： | 1 |
| 10 | Extended dissolution studies of cellulose in imidazolium based ionic liquids 显示文摘 | JURGEN V TINA E CLAUDIA H | 2009 | Green Chemistry2009，11，3： | 1 |
| 11 | Synthesis,characterization,and ion exchange properties of hydrotalcite Mg6Al2(OH)16(A)x(A')2-x·4H2O(A,A'=Cl-,Br-,I-and NO3-,2 ≤ x ≥0) derivaties显示文摘 | SHIRLEY L JAMES L K JAMES V TINA M N | 2003 | Chem Master2003，15，19： | 1 |
| 12 | Targeting of immunoliposomes to endothelial cells using a scFv fragment directed against human endoglin (CD105)显示文摘 | Peter H Fricker G | 2004 | Biochim Biophys Acta2004，1663，12： | 1 |
| 13 | Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyle globulin显示文摘 | Martin SZ Thuong V Tina P | 2006 | Blood2006，107，7： | 1 |
| 14 | Self- assembling hydrogels based on β- cyclodextrin/cholesterol inclusion complexes 显示文摘 | DE MANAKKER F V DER POT M V TINA V | 2008 | Macromolecules2008，41，： | 1 |
| 15 | Monitoring the progress of selection during SELEX显示文摘 | NINA M TINA S MARKO V | 2013 | Current Opininon in Biotechnology2013，24，1： | 1 |
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