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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 4 | Lymphopropliferative disorders with early lethality in mice deficient in CTLA-4 显示文摘 | Waterhouse P Penninger JM Timms E | 1995 | Science1995，270，5238： | 1 |
| 5 | Lymphoproliferative disorders with early lethality in micedeficient in Ctla--4显示文摘 | Waterhouse P Penninger JM Timms E Wakeham A Shahinian A Lee KP Thompson CB Griesser H Mak TW | 1995 | Science1995，270，： | 1 |
| 6 | Lymphoproliferative Disorders with Early Lethality in Mice Deficient in CTLA-4显示文摘 | WATERHOUSE P PENNINGER JM TIMMS E | 1995 | Science(S1095-9203)1995，270，5238： | 1 |
| 7 | 查看详情显示文摘 | Timms P L | | 0，，06： | 1 |
| 8 | Chlamydial infection of immune cells: altered function and implications for disease显示文摘 | Beagley K W Huston W M Hansbro P M Timms P | 2009 | Crit Rev Immunol2009，29，： | 1 |
| 9 | Polymorphism of the N-acetyhransferase (NAT2),smoking and the potential risk of periondontal disease 显示文摘 | Meisel P Timm R Sawaf H | 2000 | Arch Toxicol2000，74，6： | 1 |
| 10 | A mil- limeter-wave antenna amplitude and phase measurement system 显示文摘 | SMITH S L ARCHER J W TIMMS G P | 2012 | IEEE Transactions on Antennas & Propaga- tion2012，60，4： | 1 |
| 11 | ABCG2 - mediated Dye Cycle Violet efflux defined side population in benign and malignant prostate显示文摘 | MATHEW G TIMM EA Jr SOTOMAYOR P | 2009 | Cell Cycle2009，8，7： | 1 |
| 12 | 显示文摘 | Timms P L Stump D D Kent R A | 1966 | J Am Chem Soc1966，88，5： | 1 |
| 13 | Leveraging intensive longitudinal data to better understand health behaviors显示文摘 | Timms K P Martin C A Rivera D E | 2014 | Conf Proe IEEE Eng Med Biol Soe2014，，： | 1 |
| 14 | Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4显示文摘 | Waterhouse P Penninger JM Timms E | 1995 | Science1995，270，5238： | 1 |
| 15 | Peripheral blood level alterations of TIMP-1 ,MMP-2, and MMP-9 in patients with type 1 diabetes显示文摘 | Maxwell P Timms P Chandran S | 2001 | Diabet Med2001，18，： | 1 |
| 16 | 显示文摘 | Solan D Timms P L | 1968 | Inorg Chem1968，7，21： | 1 |
| 17 | Comparison of PCR, Nested PCR, and random amplified polymorphic DNA PCR for detection and typing of Ureaplasrna urealyticum in specimens from pregnant women显示文摘 | Knox CL Timms P | 1998 | J Clin Microbiol1998，36，10： | 1 |
| 18 | Prebiotlcs, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure显示文摘 | Scbo Ade P Marten B Weber P Timm W Asil Y Glueer C C Schrezenmeir J | 2007 | Journal of Nutrition2007，137，3： | 1 |
| 19 | 显示文摘 | Timms P L Kent R A Ehlert T C | 1965 | Nature1965，207，4993： | 1 |
| 20 | Detection of Chlamydia psittaci using DNA probes and the polymerase chain reaction FEMS Microbiol Lett显示文摘 | Rasmussen S Timms P | 1991 | FEMS Microbiol Lett1991，1，23： | 1 |
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