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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Vacuum-assisted stereotactic breast biopsy:histologic underestimation of malignant lesions 显示文摘 | Burak W E Jr Owens K E Tighe M B | 2000 | Arch Surg2000，135，6： | 1 |
| 3 | Quantitative analysis of IL- l0 and IFN-',/mRNA levels in normal cervix and human papilloma- virus type 16 assoeiated cervical preeancer 显示文摘 | EI-Sherif A M Seth R Tighe P J | 2001 | J Pathol2001，195，2： | 1 |
| 4 | Gene vaccination: plasmid DNA is more than just a blueprint显示文摘 | Tighe H Corr M Roman M | 1998 | Immunol Today1998，19，： | 1 |
| 5 | Immunostimulatory DNA se quence necessary for effective intradermal gene immunization 显示文摘 | Sato Y Roman M Tighe H | 1996 | Science1996，273，： | 1 |
| 6 | Adsorption of an- timony (V) by floodplain soils, amorphous iron (lid hydroxide and humie aeid显示文摘 | Tighe M Lockwood P Wilson S | 2005 | Journal of environmen- tal monitoring2005，7，12： | 1 |
| 7 | Immunostimulatory DNA sequences necessary for effective intradermal gene immunization显示文摘 | SATO Y ROMAN M TIGHE H | 1996 | Science1996，5273，273： | 1 |
| 8 | Immunostimulatory DNA sequences necessary for effective intradermal gene immunization 显示文摘 | Sato Y Roman M Tighe H | 1996 | Science1996，273，5273： | 1 |
| 9 | Gene vaccination:plasmid DNA is more than just a blueprint显示文摘 | Tighe H Corr M Roman M Raz E | 1998 | Immunol Today1998，19，2： | 1 |
| 10 | Hydrogel polymers and ocular spoilation process显示文摘 | Franklin V J Bright A M Tighe B J | 1993 | Trends Polymer Science1993，1，： | 1 |
| 11 | Immunostimulatory DNA sequences necessary for effective intradermal gene immunization显示文摘 | Sato Y Roman M Tighe H | 1996 | Science1996，273，： | 1 |
| 12 | Gene vaccination:plasmid DNAis more than just ablueprint显示文摘 | Tighe H Corr M Roman M | 1998 | Immunol Today1998，19，2： | 1 |
| 13 | Immunostimulatory DNA sequence necessary for effective intradermal gene immunization 显示文摘 | Sato Y Roman M Tighe H | 1996 | Science1996，273，： | 1 |
| 14 | Adsorption of antimony(V) by floodplain soils, amorphous iron(Ill) hydroxide and humic acid 显示文摘 | Tighe M Lockwood P Wilson S | 2005 | Environmental Monitoring2005，7，： | 1 |
| 15 | Aneuploid colon cancer cells have a robust spindle checkpoint 显示文摘 | Tighe A Johnson VL AlberteUa M | 2001 | EMBO Rep~2001，2，7： | 1 |
| 16 | Recruited exudative macrophages selectively produce CXCLlO following Noninfectious lung injury显示文摘 | Tighe R M Liang J R Liu N S | 2011 | Am J Respir Cell Mol Biol2011，45，4： | 1 |
| 17 | Experimental Evidence for Parity-Based 2e Periodicity in a Superconducting Single-Electron-Tunneling Transistor显示文摘 | Tuominen M T Hergenrother J M Tighe T S andTinkham M | 1992 | Phys Rev Lett1992，69，： | 1 |
| 18 | The Work Preference Inventory:Assessing intrinsic and extrinsic motivational orientations显示文摘 | Amabile T M Hill K G Hennessey B A&Tighe E M | 1994 | Journal of Personality and Social Psychology1994，，66： | 1 |
| 19 | Bleeding from bile duct varices:an unexpected hazard during therapeutic ERCP显示文摘 | Tighe M Jacobson I | 1996 | Gastrointest Endosc1996，43，3： | 1 |
| 20 | Immunostimulatory DNA sequences necessary for effective intradermal gene immunization显示文摘 | Sato Y Roman M Tighe H | 1996 | Science1996，273，： | 1 |
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