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| 1 | 筛状神经上皮性肿瘤(CRINET):具有SMARCB1缺失分子特征的预后好的非横纹肌样肿瘤显示文摘非典型畸胎样/横纹肌样肿瘤(ATRT)是以横纹肌样形态及SMARCB1(INI1)表达缺失为特征的脑肿瘤。筛状神经上皮性肿瘤(CRINETs)为筛状生长模式伴有SMARCB1表达缺失的罕见非横纹肌样脑肿瘤。小的病例系列报道提示CRINETs可能具有相对良好的预后,然而长期预后还不清楚,且CRINET是一个独立的肿瘤还是ATRT的变异亚型仍不明确。 | Johann P D Hovestadt V Thomas C 蔡珊珊 王行富 | 2017 | 临床与实验病理学杂志2017，33，2： | 4 |
| 2 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
| 5 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 6 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 7 | Perceived stress, intemal resources,and social support as determinants of mental health among young adults显示文摘 | Patrick A B Chamot E Thomas V P | 2004 | Quality Life Res2004，13，6： | 1 |
| 8 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 9 | Modelling pressure drop in HEPA filters during dynamic filtration 显示文摘 | THOMAS D CONTAL P RENAUDIN V | 1999 | Aerosol Sci1999，30，2： | 1 |
| 10 | Evidence for downy mildew races incucumber tested in Asia,Europe,and North America显示文摘 | SHETTY N V WEHNER T C THOMAS C E D0RUCH0WSKI RW VASANTH SHETTY K P | 2002 | ScientiaHorticulturae2002，94，3： | 1 |
| 11 | The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment 显示文摘 | Roberts P H Thomas K V | 2006 | Science Total Environment2006，356，13： | 1 |
| 12 | Left ventricular dysfunction after long-term right ventrieular apical pacing in the young显示文摘 | TANTENGCO M V THOMAS R L KARPAWICH P P | 2001 | J Am Coll Cardiol2001，1537，： | 1 |
| 13 | Heterologous expression and site-directed mutagenesis of the 1-aminocyclopropane-1-carboxylate oxidase from kiwifruit显示文摘 | LAY V J PRESCOTT A G THOMAS P G | 1996 | Eru J Biochem1996，242，： | 1 |
| 14 | A Study on the Chemical Spray Deposition of Zinc Oxide Thin Films and Their Structural and Electrical Properties显示文摘 | Gopchandran K G Thomas P V | 1999 | Materials Chemistry and Physics1999，58，1： | 1 |
| 15 | Effects of spirodiclofenon reproduction in a susceptible and resistant strain of tetranychusurticae显示文摘 | Steven V P Jahanqir K Thomas V L | 2009 | Experimental & AppliedAcarology2009，47，： | 1 |
| 16 | Simple Method for Quantitation of Capsaicinoids in Peppers Using Capillary Gas Chromatography显示文摘 | THOMAS B V SCHREIHER A A WEISSKOPF C P | 1998 | Agrie Food Chem1998，46，： | 1 |
| 17 | Self-assembled linear bundles of single wall carbon nanotubes and their alignment and deposition as a film in a dc field显示文摘 | KAMAT P V THOMAS K G BARAZZOUK S | 2004 | Journal of American Chemical Society2004，126，10： | 1 |
| 18 | Rate-based degradation modeling of lithium-ion cells显示文摘 | THOMAS E V BLOOM I CHRISTOPHERSEN J P | 2012 | Journal of Power Sources2012，206，： | 1 |
| 19 | A review of muhiehannel indices of class separability 显示文摘 | THOMAS I L CHING N P BENNING V M | 1987 | International Journal of Remote Sensing1987，8，： | 1 |
| 20 | Circadian genomics of the chick pineal gland in vitro显示文摘 | Karaganis S P Kumar V Beremand P D Bailey M J Thomas T L Cassone V M | 2008 | BMC Genomics2008，9206，： | 1 |
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