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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 3 | Self-enforcing wage contracts显示文摘 | Thoms J Worrall T | 1988 | Review of Economic Studies1988，55，4： | 1 |
| 4 | Changing epidemiological fea- tures of cardiac failure 显示文摘 | KANNEL W B HO K THOM T | 1994 | Br Heart J1994，72，2： | 1 |
| 5 | Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee 显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，： | 1 |
| 6 | Nitric oxide released by platelets inhibits neutrophil B2 integrin function following acute carbon monoxide poisoning 显示文摘 | THOM S R OHNISHI S T ISCHIROPOULOS H | 1994 | Toxieol Appl Pharmacol1994，128，1： | 1 |
| 7 | Heart disease and stroke statistics-2006 update:a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，6： | 1 |
| 8 | Heart disease and stroke statistics 2006 update a report from the American Heart Association Statistics Committee and Strotke Sattistics Subcommittee显示文摘 | Thom T Hase N Rosamond W | 2006 | Circulation2006，113，1： | 1 |
| 9 | Heart disease and stroke statistics-2006 update: a report from the American heart assoei- tion statistics committee and strotke sattiscs subcommittee显示文摘 | Thom T Hase N Rosamond W | 2006 | Circulation2006，113，6： | 1 |
| 10 | Heart disease and stroke statistics--2006 update: a report from the American Heart Associa- tion Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，6： | 1 |
| 11 | Diagnosis,management and treatments of hepatitis C显示文摘 | Strade D B Wright T Thom D C | 2004 | Hepatology2004，39，： | 1 |
| 12 | Heart Disease and Stroke Statistics - 2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Sub- committee显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，6： | 1 |
| 13 | Heart disease and stroke statistics2006 update:A report from the American Heart Association Statistics Committe and Stroke Statistics Subcommittee显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，85： | 1 |
| 14 | Heart disease and stroke statistics-2006 update:a report from the American Heart Associa- tion Statistics Committee and Stroke Statistics Subcommittee 显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，6： | 1 |
| 15 | Heart disease and stroke statistics-2006 update:a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Haase N Rosamond W | 2006 | Circulation2006，113，： | 1 |
| 16 | Mi- crowave dielectric properties and low temperat-ure co- firing BaTe409 with aluminum metal electrode显示文摘 | DO-KYUM K MICHAEL T L THOMS R S | 2005 | J Am Ceram Soc2005，88，12： | 1 |
| 17 | Upregulation of connexin 26 is a feature of keratinocyte differ-entiation in hyperproliferative显示文摘 | Lucke T Choudhry R Thom R Selmer I Burden A Hodgins M | | 0，，03： | 1 |
| 18 | Release of vancomycin andteicoplanin from a plasticized and resorbable gelatin sponge: invitro investigation of a new antibiotic delivery system with glycopeptides 显示文摘 | Drognitz O Thom D KrUger T | 2006 | Infection2006，1，： | 1 |
| 19 | Spontaneous intralesional haemorrhage in dysembryoplastic neurothelial tumors: a series of five cases显示文摘 | Thom M Gomez Anson B Revesz T | 1999 | J Neurosurgery and Psychiatry1999，67，： | 1 |
| 20 | Heart disease and stroke statis- tics-2006 update : a report form the American Heart Association Atatis- tics Committee and Storke Statics Subconmittee 显示文摘 | Thom T Haase N Rosamond W | 2006 | Circulation2006，113，6： | 1 |
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