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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | 无创筛查酒精相关性肝纤维化的成本效果分析显示文摘【据《Hepatology》2019年10月报道】题:无创筛查酒精相关性肝纤维化的成本效果分析(作者Asphaug L等)酒精相关性肝病常常难以被发现,直到终末期出现肝功能失代偿表现时才被引起注意。该研究旨在分析针对进展期酒精相关性肝纤维化的经济、高效的无创筛查方法的成本效果。来自挪威的Asphaug等进行了一项现实世界数据的研究,作者从丹麦多中心招募了具有肝活检病理结果的大量饮酒者,评价一级诊疗中心采用的4种筛查策略:(1)传统的肝功能化验,如果结果阳性则进一步完善腹部超声;(2)肝纤维化血清学标志物:强化的肝纤维化(ELF)试验,如果结果阳性则进一步完善肝硬度(LSM)检查;(3)三级策略:在进行第2种策略前进行Forns索引(根据年龄、血小板计数、GGT、胆固醇水平得到的无创预测公式);(4)直接进行LSM检查。应用决策树和Markov联合模型进一步评价短期结果(每项准确诊断的成本)和长期结果[质量调整生命年(QALYs)]。 | 周胜云 段志辉 ASPHAUG L THIELE M KRAG A | 2020 | 临床肝胆病杂志2020，36，1： | 2 |
| 3 | Assays for the functional activity of the mannan-binding lectin pathway of complement activation显示文摘 | M? ller-Kristensen M Jensen L | 2002 | Immunobiology2002，205，45： | 1 |
| 4 | Charging processes in low vacuum scanning electron microscopy显示文摘 | THIEL B L TOTH M GRAVEN J P | 2004 | Microscopy and Microanalysis2004，，10： | 1 |
| 5 | Depletion of human stratum corneum vitamin E:an early and sensitive in vivo marker of UV induced photooxidation显示文摘 | Thiele JJ Traver MG Packer L | 1998 | J Invest Dermatol1998，110，： | 1 |
| 6 | Multiobjective evolutionary algorithms: A comparative case study and the strength Pareto approach 显示文摘 | Zitzler E Thiele L | 1999 | IEEE Trans on Evolutionary Computation1999，3，4： | 1 |
| 7 | Comparison of multi-objective evolutionary algorithm:empirical study显示文摘 | ZITZLER E DEB K THIELE L | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 8 | Comparison of Multiobjective Evolutionary Algorithms: Empirical Results显示文摘 | Zitzler E Deb K Thiele L | 2000 | Evolutionary Computation2000，8，2： | 1 |
| 9 | Comparison of Multiobjective Evolutionary Algorithms: Empirical Results 显示文摘 | Zitzler E Thiele L | 2000 | Evolutionary Computation (S1063-6560)2000，8，2： | 1 |
| 10 | Comparison of Multiobjective Evolutionary Algorithms 显示文摘 | Zitzler E Deb K Thiele L | 2000 | IEEE Transaction on Evolutionary Computation (S1089-778X)2000，8，2： | 1 |
| 11 | Association between mannose-binding lectin and vascular complications in Type 1 dia- betes显示文摘 | TK Hansen Tarnow L Thiel S et oZ | 2004 | Scandinavian Journal Of Immunology2004，59，6： | 1 |
| 12 | Comparison of multi-ob?jective evolution algorithms: empirical results显示文摘 | ZITZLER E DEB K THIELE L | 2000 | Evolution?ary Computation2000，8，2： | 1 |
| 13 | Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and my-ocardial reperfusion injury in unselected patients with ST-segment ele-vation myocardial infarction undergoing primary percutaneous coronary intervention:the LIPSIA显示文摘 | Thiele H Hildebrand L Schirdewahn C | | 0，，： | 1 |
| 14 | Multi-objective evolutionary algorithms:a comparative case study and the strength Pareto approach显示文摘 | Zitzler E Thiele L | 1999 | IEEE Transactions on Evolutionary Computation1999，3，4： | 1 |
| 15 | Multiobjective evolutionary algorithms:A comparative case study and the strength Pareto approach显示文摘 | Zitzler E Thiele L | 1999 | Evolutionary Computation1999，3，4： | 1 |
| 16 | Comparison of multiob- jective evolutionary algorithms: empirical results显示文摘 | ZITZLER E DEB K THIELE L | 2000 | Evo- lutionary Compution2000，8，2： | 1 |
| 17 | Functionalcharacterization of GNAS mutations found in patientswith pseudohypoparathyroidism type Ic defines a newsubgroup of pseudohypoparathyroidism affecting Gsα-receptor interaction显示文摘 | Thiele S de Sanctis L Werner R | 2011 | Hum Mutat2011，32，6： | 1 |
| 18 | Multi-objective evolutionary algorithms:a comparative case study and the strength Pareto approach显示文摘 | Zitzler E Thiele L | 1999 | IEEE Transaction on Evolutionary Computation1999，3，4： | 1 |
| 19 | Multiobjective Evolutionary Algorithms:A Comparative Case Study and the Strength Pareto Approach显示文摘 | Zitzler E Thiele L | 1999 | IEEE Trans on Evolutionary Computation1999，3，4： | 1 |
| 20 | Adaptive power management for environmentally powered systems显示文摘 | Moser C Thiele L BruneUi D | 2010 | Computers IEEE Transactions2010，59，49： | 1 |
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