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| 1 | Mineralogical and geochemical features of sulfide chimneys from the 49°39′E hydrothermal field on the Southwest Indian Ridge and their geological inferences显示文摘During January–May in 2007,the Chinese research cruise DY115-19 discovered an active hydrothermal field at 49°39′E/37°47′S on the ultraslow spreading Southwest Indian Ridge (SWIR).This was also the first active hydrothermal field found along an ultraslow-spreading ridge.We analyzed mineralogical,textural and geochemical compositions of the sulfide chimneys obtained from the 49°39′E field.Chimney samples show a concentric mineral zone around the fluid channel.The mineral assemblages of the interiors consist mainly of chalcopyrite,with pyrite and sphalerite as minor constitunets.In the intermediate portion,pyrite becomes the dominant mineral,with chalcopyrite and sphalerite as minor constitunets.For the outer wall,the majority of minerals are pyrite and sphalerite,with few chalcopyrite.Towards the outer margin of the chimney wall,the mineral grains become small and irregular in shape gradually,while minerals within interstices are abundant.These features are similar to those chimney edifices found on the East Pacific Rise and Mid-Atlantic Ridge.The average contents of Cu,Fe and Zn in our chimney samples were 2.83 wt%,45.6 wt% and 3.28 wt%,respectively.The average Au and Ag contents were up to 2.0 ppm and 70.2 ppm respectively,higher than the massive sulfides from most hydrothermal fields along mid-ocean ridge.The rare earth elements geochemistry of the sulfide chimneys show a pattern distinctive from the sulfides recovered from typical hydrothermal fields along sedimentstarved mid-ocean ridge,with the enrichment of light rare earth elements but the weak,mostly negative,Eu anomaly.This is attributed to the distinct mineralization environment or fluid compositions in this area. | TAO ChunHui LI HuaiMing HUANG Wei HAN XiQiu WU GuangHai SU Xin ZHOU Ning LIN Jian HE YongHua ZHOU JianPing | 2011 | Chinese Science Bulletin2011，56，26： | 34 |
| 2 | Seafloor hydrothermal activity and polymetallic sulfide exploration on the southwest Indian ridge显示文摘Polymetallic sulfides have attracted more attentions,which are regarded as one of the potential seabed mineral resources for their high grade of precious metal elements such as Cu,Zn,Pb,Au,and Ag.Since2007,there are four China dayang cruises(CDCs)with eight legs totally,which have been carried out to investigate polymetallic sulfides on the southwest Indian ridge(SWIR),and eight hydrothermal vents have been found.In2011,the China Ocean Mineral Resources Research and Development Association(COMRA)and International Seabed Authority(ISA)signed a 15-year contract for exploration for polymetallic sulfides located on the SWIR between 46°S and 53°S.The area allocated to the COMRA is approximately 10,000 km2.In this paper,we review the recent research advances about hydrothermal activity of the SWIR by the CDCs.As for the sulfides exploration in the future,some aspects should be emphasized,such as the controlling factors of sulfide mineralization on the SWIR,prospecting methods of inactive and buried sulfide deposits,sulfides resources assessment method,and the nearbottom sulfides exploration technology systems. | Chunhui Tao Huaiming Li Xiaobing Jin Jianping Zhou Tao Wu Yonghua He Xianming Deng Chunhua Gu Guoyin Zhang Weiyong Liu | 2014 | Chinese Science Bulletin2014，59，19： | 25 |
| 3 | Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma显示文摘The blood–brain barrier(BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme(GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel(PTX) by improving the stability and targeting efficiency of PTX/albumin nanoparticles(NPs). Here we characterize PTX-loaded human serum albumin(HSA) NPs stabilized with intramolecular disulfide bonds and modified with substance P(SP) peptide as the targeting ligand. The fabricated SP-HSA-PTX NPs exhibited satisfactory drug-loading content(7.89%) and entrapment efficiency(85.7%) with a spherical structure(about 150 nm) and zeta potential of -12.0 mV. The in vitro drug release from SP-HSA-PTX NPs occurred in a redox-responsive manner. Due to the targeting effect of the SP peptide, cellular uptake of SP-HSA-PTX NPs into brain capillary endothelial cells(BCECs) and U87 cells was greatly improved.The low IC_(50), prolonged survival period and the obvious pro-apoptotic effect shown by TUNEL analysis all demonstrated that the fabricated SP-HSA-PTX NPs showed a satisfactory anti-tumor effect and could serve as a novel strategy for GBM treatment. | Chunhui Ruan Lisha Liu Yifei Lu Yu Zhang Xi He Xinli Chen Yujie Zhang Qinjun Chen Qin Guo Tao Sun Chen Jiang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 19 |
| 4 | Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors显示文摘 | Tao Ming Yuan Chunhui Xiu Dianrong Shi Xueying Tao Liyuan Ma Zhaolai Jiang Bin Zhang Zhipeng Zhang Lingfu Wang Hangyan | 2014 | Chinese Medical Journal2014，，16： | 13 |
| 5 | Two hydrothermal fields found on the Southern Mid-Atlantic Ridge显示文摘In recent years, a series of cruises have been launched by China Ocean Mineral Resources Research and Development Association (COMRA) to conduct hydrothermal activity investigation at mid-ocean ridges (MOR). Since the first active hydrothermal field at 49.6°E | TAO ChunHui LI HuaiMing YANG YaoMin NI JianYu CUI RuYong CHEN YongShun LI JiaBiao HE YongHua HUANG Wei LEI JiJiang WANG YeJian | 2011 | Science China Earth Sciences2011，54，9： | 9 |
| 6 | Mild moxibustion at Tianshu (ST 25) decreases expression of prokineticin-1 and prokineticin receptor-1 in colon tissue of rats with chronic visceral hyperalgesia显示文摘Prokineticin-1 and prokineticin receptor-1 play important roles in visceral hypersensitivity and in-flammatory pain. Visceral hypersensitivity is closely associated with irritable bowel syndrome. Mild moxibustion can relieve chronic visceral hyperalgesia in rats with irritable bowel syndrome. We hypothesized that prokineticin-1 and prokineticin receptor-1 is the key target in the mechanism. This study established chronic visceral hyperalgesia rat models by colorectal distention. Protein and mRNA expression of prokineticin-1 and prokineticin receptor-1 were determined by immunohisto-chemical method and fluorescence quantitative-PCR, respectively, and were found to be signifi-cantly increased in visceral hyperalgesic rats. Mild moxibustion at Tianshu (ST 25) decreased prokineticin-1 and prokineticin receptor-1 expression in chronic visceral hyperalgesia rats and lessen the chronic visceral hyperalgesia in rats with irritable bowel syndrome at different levels of colorectal distention pressure. | Luyi Wu Chunhui Bao Linbao Ge Cili Zhou Huirong Liu Li Qi Tao Yi Huangan Wu Xiaomei Wang | 2011 | Neural Regeneration Research2011，6，33： | 9 |
| 7 | Rare earth element geochemistry of hydrothermal deposits from Southwest Indian Ridge显示文摘The REE compositions of hydrothermal deposits and basalt samples from the Southwest Indian Ridge (SWIR) were determined with ICP-MS.The results show that there are significant differences between different types of samples although all samples show relative LREE enrichment.The contents of REE in hydrothermal sulfides and alterated rocks samples are lower (from 7.036 × 10 6 to 23.660 × 10 6),while those in the white chimney deposits are relatively higher (ranging from 84.496 × 10 6 to 103.511 × 10 6).Both of them are lower than basalts.Chondrite-normalized REE distribution patterns show that sulfides and alterated rocks samples are characterized by significant positive Eu anomalies.On the contrary,white chimney deposits have obvious negative Eu anomalies,which may be caused by abundant calcite existing in the white chimney samples.Both the content and distribution pattern of REE in sulfides suggest that REE most possibly is originally derived from hydrothermal fluids,but influenced by the submarine reducing ore-forming environment,seawater convection,mineral compositions as well as the constraint of mineral crystallizations. | CAO Zhimin CAO Hong TAO Chunhui LI Jun YU Zenghui SHU Liping | 2012 | Acta Oceanologica Sinica2012，31，2： | 6 |
| 8 | An unbalanced PD-L1/CD86 ratio in CD14^++CD16^+ monocytes is correlated with HCV viremia during chronic HCV infection显示文摘 | Jiajia Zheng Hua Liang Chunhui Xu Qiang Xu Ting Zhang Tao Shen Fengmin LU | 2014 | Cellular & Molecular Immunology2014，11，3： | 6 |
| 9 | New discovery of seafloor hydrothermal activity on the Indian Ocean Carlsberg Ridge and Southern North Atlantic Ridge-progress during the 26th Chinese COMRA cruise显示文摘The 26th Chinese COMRA (China Ocean Mineral Resources Research & Development Association) cruise was an important cruise. The Carlsberg Ridge (CR) of the Northwest Indian Ocean and the North Atlantic Ridge (NAR), in which less investigation has been carried out for hydrothermal activities, were investigated and studied during the first two legs of the 26th COMRA cruise. During the first leg, we found one hydrothermal activity field located in the CR at 3.5 -3.8 N on the Northwest Indian Ocean Ridge (NWIR), and sampled seafloor polymetallic sulfide deposits where only abnormalities were found before. During the second leg, we found a new hydrothermal anomaly field located in the NAR at 4 -7 N. The discovery of two hydrothermal and anomaly fields filled in the gap of hydrothermal investigation and study in the corresponding regions for China. | TAO Chunhui WU Guanghai DENG Xianming QIU Zhongyan HAN Chenhua LONG Yanmei | 2013 | Acta Oceanologica Sinica2013，32，8： | 5 |
| 10 | Time correction of the ocean bottom seismometers deployed at the southwest Indian ridge using ambient noise cross-correlation显示文摘Seismic monitoring using ocean bottom seismometers(OBS) is an efficient method for investigating earthquakes in mid-ocean ridge far away from land. Clock synchronization among the OBSs is difficult without direct communication because electromagnetic signals cannot propagate efficiently in water. Time correction can be estimated through global positioning system(GPS) synchronization if clock drift is linear before and after the deployment. However, some OBSs in the experiments at the southwest Indian ridge(SWIR) on the Chinese DY125-34 cruise had not been re-synchronized from GPS after recovery. So we attempted to estimate clock drift between each station pairs using time symmetry analysis(TSA) based on ambient noise cross-correlation. We tested the feasibility of the TSA method by analyzing daily noise cross-correlation functions(NCFs) that extract from the data of another OBS experiment on the Chinese DY125-40 cruise with known clock drift and the same deployment site. The results suggest that the NCFs' travel time of surface wave between any two stations are symmetrical and have an opposite growing direction with the date. The influence of different band-pass filters,different components and different normalized methods was discussed. The TSA method appeared to be optimal for the hydrophone data within the period band of 2–5 s in dozens of km-scale interstation distances. A significant clock drift of ~2 s was estimated between OBSs sets through linear regression during a 108-d deployment on the Chinese cruise DY125-34. Time correction of the OBS by the ambient noise cross-correlation was demonstrated as a practical approach with the appropriate parameters in case of no GPS re-synchronization. | LIU Yunlong LIU Cai TAO Chunhui YAO Huajian QIU Lei WANG Ao RUAN Aiguo WANG Hanchuang ZHOU Jianping LI Huaiming DONG Chuanwan | 2018 | Acta Oceanologica Sinica2018，37，5： | 5 |
| 11 | Petrophysical characteristics of rocks and sulfides from the SWIR hydrothermal field显示文摘Study of petrophysical properties of rocks in seafloor hydrothermal fields has great significance for investigation of seafloor hydrothermal activities,especially for polymetallic sulfides prospecting.In the present study,based on the current experimental conditions,we conducted systematic experiments to measure the magnetic susceptibility,electrical resistivity,porosity,density,as well as acoustic wave velocity of seafloor rocks and sulfides.Subsequently,we measured the physical characteristics of hydrothermal sulfides,basalts and peridotites which were collected from newly discovered seafloor hydrothermal fields at 49.6°E,50.5°E,51°E,63.5°E,and 63.9°E of the Southwest Indian Ridge(SWIR).Previously available and newly collected data were combined to characterize the physical differences between polymetallic sulfides and rocks.We also discussed the impact of hydrothermal alteration on the bedrock and demonstrated how these petrophysical properties of rocks can help in geophysical prospecting of seafloor hydrothermal fields as indicators. | TAO Chunhui WU Tao JIN Xiaobing DOU Bingjun LI Huaiming ZHOU Jianping | 2013 | Acta Oceanologica Sinica2013，32，12： | 5 |
| 12 | Use of portable X-ray fluorescence in the analysis of surficial sediments in the exploration of hydrothermal vents on the Southwest Indian Ridge显示文摘Hydrothermal plumes released from the eruption of sea floor hydrothermal fluids contain large amounts of oreforming materials. They precipitate within certain distances from the hydrothermal vent. Six surficial sediment samples from the Southwest Indian Ridge(SWIR) were analyzed by a portable X-ray fluorescence(PXRF) analyzer on board to find a favorable method fast and efficient enough for sea floor sulfide sediment geochemical exploration. These sediments were sampled near, at a moderate distance from, or far away from hydrothermal vents. The results demonstrate that the PXRF is effective in determining the enrichment characteristics of the oreforming elements in the calcareous sediments from the mid-ocean ridge. Sediment samples(>40 mesh) have high levels of elemental copper, zinc, iron, and manganese, and levels of these elements in sediments finer than 40 mesh are lower and relatively stable. This may be due to relatively high levels of basalt debris/glass in the coarse sediments, which are consistent with the results obtained by microscopic observation. The results also show clear zoning of elements copper, zinc, arsenic, iron, and manganese in the surficial sediments around the hydrothermal vent. Sediments near the vent show relatively high content of the ore-forming elements and either high ratios of copper to iron content and zinc to iron content or high ratios of copper to manganese content and zinc to manganese content. These findings show that the content of the ore-forming elements in the sediments around hydrothermal vents are mainly influenced by the distance of sediments to the vent, rather than grain size. In this way, the PXRF analysis of surface sediment geochemistry is found to satisfy the requirements of recognition geochemical anomaly in mid-ocean ridge sediments. Sediments with diameters finer than 40 mesh should be used as analytical samples in the geochemical exploration for hydrothermal vents on mid-oceanic ridges. The results concerning copper, zinc, arsenic, iron, and manganese and their ratio features can be used as indicators in sediment geochemical exploration of seafloor sulfides. | LIAO Shili TAO Chunhui LI Huaiming ZHANG Guoyin LIANG Jin YANG Weifang | 2017 | Acta Oceanologica Sinica2017，36，7： | 5 |
| 13 | Newly discovered hydrothermal fields along the ultraslow-spreading Southwest Indian Ridge around 63°E显示文摘The ultraslow-spreading Southwest Indian Ridge(SWIR) to the east of the Melville fracture zone is characterized by very low melt supply and intensive tectonic activity. Due to its weak thermal budget and extremely slow spreading rate, the easternmost SWIR was considered to be devoid of hydrothermal activity until the discovery of the inactive Mt. Jourdanne hydrothermal field(27°51′S, 63°56′E) in 1998. During the COMRA DY115-20 cruise in2009, two additional hydrothermal fields(i.e., the Tiancheng(27°51′S, 63°55′E) and Tianzuo(27°57′S, 63°32′E)fields) were discovered. Further detailed investigations of these two hydrothermal sites were conducted by Chinese manned submersible Jiaolong in 2014–2015. The Tiancheng filed can be characterized as a lowtemperature(up to 13.2°C) diffuse flow hydrothermal field, and is hosted by fractured basalts with hydrothermal fauna widespread on the seafloor. The Tianzuo hydrothermal field is an inactive sulfide field, which is hosted by ultramafic rocks and controlled by detachment fault. The discovery of the three hydrothermal fields around Segment #11 which receives more melt than the regional average, provided evidence for local enhanced magmatism providing heat source to drive hydrothermal circulation. We further imply that hydrothermal activity and sulfide deposits may be rather promising along the easternmost SWIR. | CHEN Jie TAO Chunhui LIANG Jin LIAO Shili DONG Chuanwan LI Huaiming LI Wei WANG Yuan YUE Xihe HE Yonghua | 2018 | Acta Oceanologica Sinica2018，37，11： | 5 |
| 14 | Viscosity and aggregation structure of nanocolloidal dispersions显示文摘In this work,the effects of nanoparticle size,particle volume fraction and pH on the viscosity of silicon dioxide nanocolloidal dispersions are investigated.Both size and pH are found to significantly affect nanocolloid viscosity.Two models are used to study the effect of aggregate structure on the viscosity of the nanocolloidal dispersion.The fractal concept is introduced to describe the irregular and dynamic aggregate structure.The structure of aggregates,which is considered to play an important role in viscosity,is affected by both intermolecular and electrostatic forces.The particle interaction is primarily affected by particle distance and becomes stronger with decreasing particle size and increasing volume fraction.The aggregate structure is also affected by the pH of the solution.Studying the relationship between pH and zeta-potential shows that with the neutralization of charges on the particle surface and decreasing electrical repulsion force,the particle interaction becomes dominated by attractive forces and the aggregates form a more compact structure. | WANG Tao NI MingJiang LUO ZhongYang SHOU ChunHui CEN KeFa | 2012 | Chinese Science Bulletin2012，57，27： | 4 |
| 15 | TEM investigations of South Atlantic Ridge 13.2°S hydrothermal area显示文摘According to the exploration contract about polymetallic sulfides in the SWIR(Southwest Indian Ridge)signed by China with the International Seabed Authority,to delineate sulfide minerals and estimate resource quantity are urgent tasks.We independently developed our first coincident loop Transient Electromagnetic Method(TEM)device in 2010,and gained the TEM data for seafloor sulfide at South Atlantic Ridge 13.2°S in June 2011.In contrast with the widely applied CSEM(Marine controlled-source electromagnetic)method,whose goal is to explore hydrocarbons(oil/gas)of higher resistivity than seawater from 102to 103m below the sea floor,the TEM is for low resistivity minerals,and the target depth is from 0 to 100 m below the sea floor.Based on the development of complex sulfide geoelectrial models,this paper analyzed the TEM data obtained,proposing a new method for seafloor sulfide detection.We present the preliminary trial results,in the form of apparent resistivity sections for both half-space and full-space conditions.The results correspond well with the observations of the actual hydrothermal vent area,and the detection depth reached50–100m below the bed,which verified the capability of the equipment. | TAO Chunhui XIONG Wei XI Zhenzhu DENG Xianming XU Yixian | 2013 | Acta Oceanologica Sinica2013，32，12： | 3 |
| 16 | 15.4% Efficiency all-polymer solar cells显示文摘We report all-polymer solar cells(All-PSCs) with record-high power conversion efficiency(PCE) through tuning the molecular weights of the polymer donor(PBDB-T) to form optimal active layer morphology. By combining the polymer donors with a newly reported polymer acceptor(PJ1), an unprecedented high PCE of 15.4% and fill factor over 75% were achieved for the AllPSCs with the medium molecular weight polymer donor(PBDB-TMW), which is the highest value for All-PSCs reported so far.Detailed morphology investigation revealed that the proper phase separation in the PBDB-TMW:PJ1 blend should account for the superior device performance as PBDB-TMW exhibits appropriate miscibility with the polymer acceptor PJ1. These results demonstrated that the device performance of All-PSCs could be fully comparable to that of small molecular acceptor-based PSCs. The formation of optimized morphology via precise control of molecular weights of polymer donors and acceptors is crucial to achieve this goal. | Long Zhang Tao Jia Langheng Pan Baoqi Wu Zaiyu Wang Ke Gao Feng Liu Chunhui Duan Fei Huang Yong Cao | 2021 | Science China Chemistry2021，64，3： | 2 |
| 17 | A hydrothermal investigation system for the Qianlong-Ⅱ autonomous underwater vehicle显示文摘Qianlong-Ⅱ is a fully autonomous underwater vehicle designed for the investigation of submarine resources,particularly polymetallic sulfides. It was used to successfully explore hydrothermal fields on the Southwest Indian Ridge. Here, we summarized the exploration of hydrothermal systems using Qianlong-Ⅱ, including detailed descriptions of its implementation along with the systems used for data management and fast mapping. We also introduced a method to remove platform magnetic interference using magnetic data while Qianlong-Ⅱ is spinning. Based on hydrothermal anomalies collected by Qianlong-Ⅱ, we developed a rapid method for locating hydrothermal vents. Taking one dive as an example, we systemically demonstrated the process for analyzing hydrothermal survey data to locate hydrothermal vents. | Tao Wu Chunhui Tao Jinhui Zhang Ao Wang Guoyin Zhang Jianping Zhou Xianming Deng | 2019 | Acta Oceanologica Sinica2019，38，3： | 2 |
| 18 | The deep structure of the Duanqiao hydrothermal field at the Southwest Indian Ridge显示文摘Polymetalic sulfide is the main product of sea-floor hydrothermal venting, and has become an important sea-floor mineral resources for its rich in many kinds of precious metal elements. Since 2007, a number of investigations have been carried out by the China Ocean Mineral Resources Research and Development Association(COMRA)cruises(CCCs) along the Southwest Indian Ridge(SWIR). In 2011, the COMRA signed an exploration contract of sea-floor polymetallic sulfides of 10 000 km2 on the SWIR with the International Seabed Authority. Based on the multibeam data and shipborne gravity data obtained in 2010 by the R/V Dayang Yihao during the leg 6 of CCCs21, together with the global satellite surveys, the characteristics of gravity anomalies are analyzed in the Duanqiao hydrothermal field(37°39′S, 50°24′E). The 'subarea calibration' terrain-correcting method is employed to calculate the Bouguer gravity anomaly, and the ocean bottom seismometer(OBS) profile is used to constrain the two-dimensional gravity anomaly simulation. The absent Moho in a previous seismic model is also calculated.The results show that the crustal thickness varies between 3 and 10 km along the profile, and the maximum crustal thickness reaches up to 10 km in the Duanqiao hydrothermal field with an average of 7.5 km. It is by far the most thicker crust discovered along the SWIR. The calculated crust thickness at the Longqi hydrothermal field is approximately 3 km, 1 km less than that indicated by seismic models, possibly due to the outcome of an oceanic core complex(OCC). | SUN Chaofeng WU Zhaocai TAO Chunhui RUAN Aiguo ZHANG Guoyin GUO Zhikui HUANG Enxian | 2018 | Acta Oceanologica Sinica2018，37，3： | 2 |
| 19 | A data processing method for MAPR hydrothermal plume turbidity data and its application in the Precious Stone Mountain hydrothermal field显示文摘Hydrothermal plume is an important constituent of seabed hydrothermal circulation and is also one of the characteristics of active hydrothermal vents. Portable Miniature Autonomous Plume Recorders(MAPR) attached to a towed deep-sea instrument was used to search for hydrothermal plumes and hydrothermal vents. We introduced the basic principle of MAPR based on deep towing technology to detect plumes, then analyzed the factors affecting the quality of the MAPR data and presented a data correction method for MAPR, including instrument location correction, noise reduction processing, system error elimination and seawater background reduction. Finally we applied the method to analyze MAPR data obtained during the Chinese DY115-21 cruise on R/V Dayang I in the 'Precious Stone Mountain' hydrothermal field on the Galapagos Microplate. The results provided a better understanding of the distribution of the hydrothermal activity in this field, indicating the presence of a new hydrothermal vent. | CHEN Sheng TAO Chunhui LI Huaiming CHEN Yongshun ZHOU Jianping WU Tao | 2014 | Acta Oceanologica Sinica2014，33，8： | 2 |
| 20 | Association between hsa-miR-34b/c rs4938723 T>C promoter polymorphism and cancer risk: a meta-analysis based on 6,036 cases and 6,204 controls显示文摘Objective: Emerging evidence shows that microRNAs(miRNAs) function as tumor suppressors or oncogenes in human carcinogenesis. A single nucleotide polymorphism(SNP) located in the pri-miRNA promoter may affect the processing and expression of mature miRNA. However, previous studies showed conflicting results regarding the association of hsa-miR-34b/c rs4938723 T > C promoter polymorphism with cancer. Therefore, we conducted a meta-analysis to determine the association of polymorphism with cancer risk.Methods: A computerized search of PubMed, Web of Science, and Chinese National Knowledge Infrastructure(CNKI) for publications on hsa-miR-34b/c rs4938723 T > C promoter polymorphism and cancer risk was performed and the genotype data were analyzed in a meta-analysis. Odds ratios(ORs) with 95% confidence intervals(CIs) were estimated to assess the association. Test of heterogeneity, cumulative meta-analysis, sensitivity analysis and assessment of bias were performed in our meta-analysis by STATA software 12.0.Results: There was no significant association between hsa-miR-34b/c rs4938723 polymorphism and overall cancer risk in the comparison models. Moreover, subgroup analysis revealed that the variant CT(OR =1.19, 95% CI: 1.03-1.37) and CC/CT(OR =1.18, 95% CI: 1.03-2.35) genotypes were associated with an increased risk of hepatocellular carcinoma(HCC) compared with wild-type TT genotype. However, a decreased risk of colorectal cancer(CRC) was found in the genetic model of CC/TT(OR =0.66, 95% CI: 0.47-0.92) and CC/CTTT(OR =0.67, 95% CI: 0.49-0.93). Conclusions: The results suggest that hsa-miR-34b/c rs4938723 polymorphism may play an opposite role in different types of cancer based on current studies, which is the main origin of heterogeneity in this metaanalysis. Further large-scale studies and functional studies between this polymorphism and cancer risk are warranted. | Tao Tao Shuqiu Chen Bin Xu Chunhui Liu Yiduo Wang Yeqing Huang Ming Chen | 2014 | Chinese Journal of Cancer Research2014，26，3： | 2 |
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