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| 1 | Effect of pegylated interferon alpha 2b plus ribavirin treatment on plasma transforming growth factor-β1,metalloproteinase-1,and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis C显示文摘AIM: To evaluate the effect of antiviral treatment on plasma levels of transforming growth factor-β1 (TGF-β1),metalloproteinase 1 (MMP-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with chronic hepatitis C.METHODS: TGF-β1, MMP-1, and TIMP-1 plasma concentrations were measured by an enzyme immunoassay in 28 patients, during 48 wk of treatment with pegylated interferon-alpha 2b (PEG-IFN-α2b) plus ribavirin (RBV)and after 24 wk of follow-up. Patients were divided into two groups: responders (R) and non-responders (NR)related to achieved sustained virologic response. Normal values were evaluated in plasma samples of 13 healthy volunteers.RESULTS: Baseline plasma concentrations of TGF-β1and TIMP-1 (30.9±3.7 and 1506±61 ng/mL respectively)measured in all subjects significantly exceeded the normal values (TGF-β1:18.3±1.6 ng/mL and TIMP-1:1102±67 ng/mL). In contrast, pretreatment MMP-1mean level (6.5±0.9 ng/mL) was significantly lower than normal values (11.9±0.9 ng/mL). Response to the treatment was observed in 12 patients (43%). TGF-β1mean concentration measured during the treatment phase decreased to the control level in both groups.However at wk 72, values of NR patients increased and became significantly higher than in R group.TIMP-1 concentrations in R group decreased during the treatment to the level similar to normal. In NR group,TIMP-1 remained significantly elevated during treatment and follow-up phase and significant difference between both groups was demonstrated at wk 48 and 72. MMP-1levels were significantly decreased in both groups at baseline. Treatment caused rise of its concentration only in the R group, whereas values in NR group remained on the level similar to baseline. Statistically significant difference between groups was noted at wk 48 and 72.CONCLUSION: These findings support the usefulness of TGF-β1, TIMP-1, and MMP-1 in the management of chronic hepatitis C. Elevated TIMP-1 and low MMP-1plasma concentrations during antiviral therapy may indicate medication failure. | Robert Flisiak Jerzy Jaroszewicz Tadeusz W Lapiski Iwona Flisiak Danuta Prokopowiczi | 2005 | World Journal of Gastroenterology2005，11，43： | 7 |
| 2 | Soluble ST2 protein in chronic heart failure is independent of traditional factors显示文摘 | Karolina W Tadeusz P Agata S | 2013 | Arch Med Sci2013，9，1： | 1 |
| 3 | Photo - synthetic activities of cadmium-treated tomato plants 显示文摘 | TADEUSZ B LUCYNA W MARIA K | 1980 | Physiol Plant1980，48，： | 1 |
| 4 | A review of routing protocols for mobile Ad Hoc networks显示文摘 | MEHRAN A TADEUSZ W ERYK D | 2004 | Ad Hoc Networks2004，2，1： | 1 |
| 5 | Modulation of properties of phospholipid membranes by the long-chain polypemol (C160)显示文摘 | Teresa J Krystyna W Tadeusz C | 2000 | Chemistry and Physics Lipids2000，106，： | 1 |
| 6 | Experimental and numerical investigations of the averaging Pitot tube and analysis of installation effects on the flow coefficient显示文摘 | DANIEWL W TADEUSZ C JANUSZ K | 2008 | Flow Measurement and Instrumentation2008，19，： | 1 |
| 7 | Purification of two lowmolecular-mass serine proteinase inhibitors from chicken liver显示文摘 | Agnieszka L Jolanta P Tadeusz W | 1999 | Journal of Chromatography1999，852，6： | 1 |
| 8 | Current and emerging therapies for acute myeloid leukemia显示文摘 | Tadeusz R Agnieszka W | 2009 | Clinical Therapeutics2009，31，2： | 1 |
| 9 | Energy & Fuels显示文摘 | Chandra W Angle Leo Lue Tadeusz Dabros Hassan A Hamza | 2005 | 19(5) :2 0142005，19，5： | 1 |
| 10 | Modulation of properties of phospholipid membranes by the long-chain polypernol (C160) 显示文摘 | Teresa J Krystyna W Tadeusz C | 2000 | ChemPhysLipids2000，106，1： | 1 |
| 11 | an Antifungal Bisα-ω-amino Alcohol Glycoside from the Marine Sponge Oceanapia phillipensis显示文摘 | Gillian M N Tamilyn W H Tadeusz F M | 1999 | J Nat Prod1999，，： | 1 |
| 12 | The effect of phosphate ester derivates of polyprenol on model membrane stability 显示文摘 | KRYSTYNA W TADEUSZ J | 2001 | Cell Biol Mol Lett2001，6，2： | 1 |
| 13 | Clinical experience with the Medpor porous polyethylene implant显示文摘 | Tadeusz W | 1993 | Aesth Plast Surg1993，17，： | 1 |
| 14 | The relationship betw-een the spatial distribution of fish,zooplankton and otherenvir-onmental parameters in the Solina reservoir,Poland显示文摘 | Andrzej S W Malgorzata G Tadeusz P | 2000 | Aquat Living Resour2000，13，5： | 1 |
| 15 | Effect of dietary cadmium and/or lead on histopathological changes in the kidneys and liver of bank voles Myodes glareolus kept in different group densities显示文摘 | Aneta Salińska Tadeusz W?ostowski El?bieta Zambrzycka | 2012 | Ecotoxicology2012，，8： | 1 |
| 16 | Enriched environment attenuates cell genesis in subventricular zone after focal ische mia in mice and decreases migration of newborn cells to the striatum显示文摘 | Josefine N Tadeusz W Jelena P | 2006 | Stroke2006，37，： | 1 |
| 17 | Modulation of properties of phospholipid membranes by the long - chain polypemol (C160) 显示文摘 | Teresa J Krystyna W Tadeusz C | 2000 | Chemistry and Physics Lipids2000，106，： | 1 |
| 18 | The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice 显示文摘 | Ewa C Tadeusz W Alicja K | 2006 | Journal of Trace Elements in Medicine and Biology2006，19，： | 1 |
| 19 | Experimental investigations of boiling heat transfer hysteresis on sintered, met- al-fibrous, porous structures 显示文摘 | TADEUSZ M W | 2009 | Experimental Thermal and Fluid Science2009，33，3： | 1 |
| 20 | Optimization of Agrobacterium-mediated transient assays of gene expression in lettuce,tomato and Arabidopsis显示文摘 | Tadeusz W Anna T Richard M | 2005 | Plant Biotechnology Journal2005，3，： | 1 |
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